Entity Details

Primary name AK1C2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52895
EntryNameAK1C2_HUMAN
FullNameAldo-keto reductase family 1 member C2
TaxID9606
Evidenceevidence at protein level
Length323
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesAKR1C2

GO terms

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GOName
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0005829 cytosol
GO:0006693 prostaglandin metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007586 digestion
GO:0008202 steroid metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0016229 steroid dehydrogenase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 phenanthrene 9,10-monooxygenase activity
GO:0030855 epithelial cell differentiation
GO:0031406 carboxylic acid binding
GO:0032052 bile acid binding
GO:0042448 progesterone metabolic process
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0047023 androsterone dehydrogenase activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0047086 ketosteroid monooxygenase activity
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047718 indanol dehydrogenase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0071395 cellular response to jasmonic acid stimulus
GO:0071799 cellular response to prostaglandin D stimulus
GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily
IPR044482 Aldo-keto reductase family 1 member CFamilyFamily

Diseases

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Disease IDSourceNameDescription
614279 OMIM46,XY sex reversal 8 (SRXY8)A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01586 Ursodeoxycholic acidDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06777 Chenodeoxycholic acidDrugbanksmall molecule
DB07768 EpitestosteroneDrugbanksmall molecule
DB12612 OzanimodDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
AK1C2_HUMANLTOR5_HUMANBioGRID, IntAct23414517 details
AK1C2_HUMANAK1C2_HUMANBioGRID11514561 details
AK1C2_HUMANISG15_HUMANBioGRID33024031 details