Entity Details

Primary name MK12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53778
EntryNameMK12_HUMAN
FullNameMitogen-activated protein kinase 12
TaxID9606
Evidenceevidence at protein level
Length367
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK12

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006975 DNA damage induced protein phosphorylation
GO:0007165 signal transduction
GO:0007517 muscle organ development
GO:0010952 positive regulation of peptidase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0045445 myoblast differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008352 Mitogen-activated protein (MAP) kinase p38-likeFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR038786 Mitogen-activated protein kinase 12FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01017 MinocyclineDrugbanksmall molecule
DB02482 PhosphonothreonineDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB05157 KC706Drugbanksmall molecule
DB05403 CEP-1347Drugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
MK12_HUMANPKN1_HUMANBioGRID, HPRD, IntAct12761180 details
MK12_HUMANGTF2I_HUMANBioGRID, IntAct21988832 details
MK12_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
MK12_HUMANDLG1_HUMANBioGRID, HPRD, IntAct16637659 25241761 27416801 30126976 details
MK12_HUMANPGFRL_HUMANBioGRID, MINT24412244 details
MK12_HUMANPTN4_HUMANBioGRID, MINT25158884 27246854 details
MK12_HUMANSIAH1_HUMANBioGRID, IntAct25416956 details
MK12_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
MK12_HUMANSCRIB_HUMANBioGRID, IntAct, MINT24550280 30126976 details
MK12_HUMANPTN3_HUMANBioGRID, DIP20332238 25728925 details
MK12_HUMANSNTB1_HUMANHPRD, IntAct10212242 30126976 details
MK12_HUMANA4_HUMANIntAct32814053 details
MK12_HUMANSNTA1_HUMANBioGRID, HPRD10212242 details
MK12_HUMANHTRA2_HUMANBioGRID17906618 details
MK12_HUMANMBP_HUMANBioGRID17906618 details
MK12_HUMANMP2K6_HUMANBioGRID, HPRD11062067 12761180 details
MK12_HUMANERBIN_HUMANBioGRID15123239 details
MK12_HUMANCPZIP_HUMANBioGRID15850461 details
MK12_HUMANTAU_HUMANBioGRID, HPRD11104762 11181841 12226093 12387894 1330687 15632108 7566346 9199504 9353289 9565682 9735171 9771888 9832145 details
MK12_HUMANDUS1_HUMANBioGRID, HPRD, IntAct11062068 25241761 details
MK12_HUMANTAB1_HUMANBioGRID12429732 details
MK12_HUMANGCH1_HUMANBioGRID19294699 details
MK12_HUMANGRB2_HUMANHPRD9019171 details
MK12_HUMANMP2K4_HUMANHPRD11062067 details
MK12_HUMANMK12_HUMANHPRD10567720 details
MK12_HUMANEF2K_HUMANHPRD12171600 details
MK12_HUMANMAPK5_HUMANHPRD9628874 details
MK12_HUMAN3BP5_HUMANHPRD15158451 details
MK12_HUMANDLG2_HUMANHPRD16637659 details
MK12_HUMANDLG3_HUMANHPRD16637659 details
MK12_HUMANDLG4_HUMANHPRD16637659 details
MK12_HUMANRGS3_HUMANHPRD16637659 details