Entity Details

Primary name EPHB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54762
EntryNameEPHB1_HUMAN
FullNameEphrin type-B receptor 1
TaxID9606
Evidenceevidence at protein level
Length984
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesEPHB1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0014719 skeletal muscle satellite cell activation
GO:0021952 central nervous system projection neuron axonogenesis
GO:0022008 neurogenesis
GO:0030010 establishment of cell polarity
GO:0030425 dendrite
GO:0031290 retinal ganglion cell axon guidance
GO:0031589 cell-substrate adhesion
GO:0031901 early endosome membrane
GO:0033674 positive regulation of kinase activity
GO:0043005 neuron projection
GO:0043235 receptor complex
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051965 positive regulation of synapse assembly
GO:0060326 cell chemotaxis
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:1901214 regulation of neuron death
GO:1902723 negative regulation of skeletal muscle satellite cell proliferation
GO:1902725 negative regulation of satellite cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Early endosome membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034231 Ephrin type-B receptor 1, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR042819 EphB1 , SAM domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule