Entity Details

Primary name IPKA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61925
EntryNameIPKA_HUMAN
FullNamecAMP-dependent protein kinase inhibitor alpha
TaxID9606
Evidenceevidence at protein level
Length76
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesPKIA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0004860 protein kinase inhibitor activity
GO:0004862 cAMP-dependent protein kinase inhibitor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0034236 protein kinase A catalytic subunit binding
GO:0042308 negative regulation of protein import into nucleus
GO:2000480 negative regulation of cAMP-dependent protein kinase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR004171 cAMP-dependent protein kinase inhibitorFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB03374 3,5-DiiodotyrosineDrugbanksmall molecule
DB04707 HydroxyfasudilDrugbanksmall molecule
DB06959 (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamineDrugbanksmall molecule
DB07107 (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINEDrugbanksmall molecule
DB07204 (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINEDrugbanksmall molecule
DB07583 (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINEDrugbanksmall molecule
DB07854 N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDrugbanksmall molecule
DB07855 (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINEDrugbanksmall molecule
DB07856 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINEDrugbanksmall molecule
DB07857 (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamineDrugbanksmall molecule
DB07858 (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamineDrugbanksmall molecule
DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDrugbanksmall molecule
DB07860 (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINEDrugbanksmall molecule
DB07876 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINEDrugbanksmall molecule
DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDrugbanksmall molecule
DB07995 H-89Drugbanksmall molecule
DB07996 5-(2-methylpiperazine-1-sulfonyl)isoquinolineDrugbanksmall molecule
DB07997 N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDEDrugbanksmall molecule
DB08070 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINEDrugbanksmall molecule
DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDrugbanksmall molecule
DB08113 3-pyridin-4-yl-1H-indazoleDrugbanksmall molecule
DB08114 5-benzyl-1,3-thiazol-2-amineDrugbanksmall molecule
DB08148 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDrugbanksmall molecule
DB08149 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineDrugbanksmall molecule
DB08150 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminiumDrugbanksmall molecule
DB08162 FasudilDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08568 A-674563Drugbanksmall molecule
DB08569 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLEDrugbanksmall molecule
DB08756 Y-27632Drugbanksmall molecule