Entity Details

Primary name SMHD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA6NHR9
EntryNameSMHD1_HUMAN
FullNameStructural maintenance of chromosomes flexible hinge domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length2005
SequenceStatuscomplete
DateCreated2008-04-29
DateModified2021-06-02

Ontological Relatives

GenesSMCHD1

GO terms

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GOName
GO:0001740 Barr body
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0006302 double-strand break repair
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0016887 ATP hydrolysis activity
GO:0035861 site of double-strand break
GO:0042803 protein homodimerization activity
GO:0043584 nose development
GO:0045739 positive regulation of DNA repair
GO:0060820 inactivation of X chromosome by heterochromatin assembly
GO:0060821 inactivation of X chromosome by DNA methylation
GO:0070868 heterochromatin organization involved in chromatin silencing
GO:2000042 negative regulation of double-strand break repair via homologous recombination
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Chromosome

Domains

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DomainNameCategoryType
IPR010935 SMCs flexible hingeDomainDomain
IPR036277 SMCs flexible hinge superfamilyFamilyHomologous superfamily
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR038892 Structural maintenance of chromosomes flexible hinge domain-containing protein 1FamilyFamily

Diseases

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