Entity Details

Primary name PI42B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78356
EntryNamePI42B_HUMAN
FullNamePhosphatidylinositol 5-phosphate 4-kinase type-2 beta
TaxID9606
Evidenceevidence at protein level
Length416
SequenceStatuscomplete
DateCreated2004-05-24
DateModified2021-06-02

Ontological Relatives

GenesPIP4K2B

GO terms

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GOName
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005776 autophagosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007166 cell surface receptor signaling pathway
GO:0010506 regulation of autophagy
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0042803 protein homodimerization activity
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0061909 autophagosome-lysosome fusion
GO:0090217 negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
GO:2000786 positive regulation of autophagosome assembly

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, coreDomainDomain
IPR023610 Phosphatidylinositol-4-phosphate 5-kinaseFamilyFamily
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule