Entity Details

Primary name PHLD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP80108
EntryNamePHLD_HUMAN
FullNamePhosphatidylinositol-glycan-specific phospholipase D
TaxID9606
Evidenceevidence at protein level
Length840
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesGPLD1

GO terms

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GOName
GO:0001503 ossification
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002430 complement receptor mediated signaling pathway
GO:0004621 glycosylphosphatidylinositol phospholipase D activity
GO:0004630 phospholipase D activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0006501 C-terminal protein lipidation
GO:0006507 GPI anchor release
GO:0008285 negative regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010595 positive regulation of endothelial cell migration
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010897 negative regulation of triglyceride catabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010983 positive regulation of high-density lipoprotein particle clearance
GO:0017080 sodium channel regulator activity
GO:0031012 extracellular matrix
GO:0032869 cellular response to insulin stimulus
GO:0035690 cellular response to drug
GO:0035701 hematopoietic stem cell migration
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0046470 phosphatidylcholine metabolic process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051047 positive regulation of secretion
GO:0070062 extracellular exosome
GO:0070633 transepithelial transport
GO:0071277 cellular response to calcium ion
GO:0071397 cellular response to cholesterol
GO:0071401 cellular response to triglyceride
GO:0071467 cellular response to pH
GO:0097241 hematopoietic stem cell migration to bone marrow
GO:1900076 regulation of cellular response to insulin stimulus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001028 Glycoprotein phospholipase DFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR029002 Phospholipase C/DDomainDomain

Diseases

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