Entity Details

Primary name DHSO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00796
EntryNameDHSO_HUMAN
FullNameSorbitol dehydrogenase
TaxID9606
Evidenceevidence at protein level
Length357
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesSORD

GO terms

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GOName
GO:0000721 (R,R)-butanediol dehydrogenase activity
GO:0003939 L-iditol 2-dehydrogenase activity
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006062 sorbitol catabolic process
GO:0006970 response to osmotic stress
GO:0008270 zinc ion binding
GO:0009725 response to hormone
GO:0016020 membrane
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate
GO:0030246 carbohydrate binding
GO:0030317 flagellated sperm motility
GO:0031514 motile cilium
GO:0031667 response to nutrient levels
GO:0031966 mitochondrial membrane
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0046370 fructose biosynthetic process
GO:0046526 D-xylulose reductase activity
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0050255 ribitol 2-dehydrogenase activity
GO:0051160 L-xylitol catabolic process
GO:0051164 L-xylitol metabolic process
GO:0051287 NAD binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell projection
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR002328 Alcohol dehydrogenase, zinc-type, conserved siteSiteConserved site
IPR011032 GroES-like superfamilyFamilyHomologous superfamily
IPR013149 Alcohol dehydrogenase, C-terminalDomainDomain
IPR013154 Alcohol dehydrogenase, N-terminalDomainDomain
IPR020843 Polyketide synthase, enoylreductase domainDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB04478 Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-PyrimidineDrugbanksmall molecule

Interactions

5 interactions