Entity Details

Primary name GHRHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02643
EntryNameGHRHR_HUMAN
FullNameGrowth hormone-releasing hormone receptor
TaxID9606
Evidenceevidence at protein level
Length423
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesGHRHR

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0008340 determination of adult lifespan
GO:0008528 G protein-coupled peptide receptor activity
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016363 nuclear matrix
GO:0016520 growth hormone-releasing hormone receptor activity
GO:0017046 peptide hormone binding
GO:0019838 growth factor binding
GO:0019933 cAMP-mediated signaling
GO:0030104 water homeostasis
GO:0030141 secretory granule
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0040018 positive regulation of multicellular organism growth
GO:0042383 sarcolemma
GO:0042445 hormone metabolic process
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043627 response to estrogen
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0048469 cell maturation
GO:0048609 multicellular organismal reproductive process
GO:0051246 regulation of protein metabolic process
GO:0051384 response to glucocorticoid
GO:0060124 positive regulation of growth hormone secretion
GO:0060133 somatotropin secreting cell development
GO:0071333 cellular response to glucose stimulus

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001879 GPCR, family 2, extracellular hormone receptor domainDomainDomain
IPR003288 GPCR, family 2, growth hormone-releasing hormone receptorFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR036445 GPCR family 2, extracellular hormone receptor domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00010 SermorelinDrugbankbiotech
DB08869 TesamorelinDrugbanksmall molecule

Interactions

3 interactions