Entity Details

Primary name PTH1R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03431
EntryNamePTH1R_HUMAN
FullNameParathyroid hormone/parathyroid hormone-related peptide receptor
TaxID9606
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPTH1R

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0002062 chondrocyte differentiation
GO:0002076 osteoblast development
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004991 parathyroid hormone receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007568 aging
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008528 G protein-coupled peptide receptor activity
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0017046 peptide hormone binding
GO:0030282 bone mineralization
GO:0031526 brush border membrane
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043621 protein self-association
GO:0045453 bone resorption
GO:0048469 cell maturation
GO:0060732 positive regulation of inositol phosphate biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001879 GPCR, family 2, extracellular hormone receptor domainDomainDomain
IPR002170 GPCR, family 2, parathyroid hormone receptorFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR036445 GPCR family 2, extracellular hormone receptor domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05084 AbaloparatideDrugbankbiotech
DB05829 Parathyroid hormoneDrugbankbiotech
DB06285 TeriparatideDrugbankbiotech