Entity Details

Primary name ATP7A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04656
EntryNameATP7A_HUMAN
FullNameCopper-transporting ATPase 1
TaxID9606
Evidenceevidence at protein level
Length1500
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesATP7A

GO terms

Show/Hide Table
GOName
GO:0001568 blood vessel development
GO:0007595 lactation
GO:0032773 positive regulation of monophenol monooxygenase activity
GO:0071456 cellular response to hypoxia
GO:0006878 cellular copper ion homeostasis
GO:0010043 response to zinc ion
GO:0016324 apical plasma membrane
GO:0007565 female pregnancy
GO:0016021 integral component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0043005 neuron projection
GO:0005802 trans-Golgi network
GO:0018205 peptidyl-lysine modification
GO:0021954 central nervous system neuron development
GO:0042428 serotonin metabolic process
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0071230 cellular response to amino acid stimulus
GO:0071280 cellular response to copper ion
GO:0010468 regulation of gene expression
GO:0042414 epinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0006825 copper ion transport
GO:0051087 chaperone binding
GO:0005507 copper ion binding
GO:0015677 copper ion import
GO:0019430 removal of superoxide radicals
GO:0001889 liver development
GO:1904959 regulation of cytochrome-c oxidase activity
GO:0032588 trans-Golgi network membrane
GO:0071236 cellular response to antibiotic
GO:0007626 locomotory behavior
GO:0030198 extracellular matrix organization
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0043473 pigmentation
GO:0048251 elastic fiber assembly
GO:0071284 cellular response to lead ion
GO:0140581 P-type monovalent copper transporter activity
GO:0001701 in utero embryonic development
GO:0005375 copper ion transmembrane transporter activity
GO:0007005 mitochondrion organization
GO:0019730 antimicrobial humoral response
GO:0031901 early endosome membrane
GO:0043588 skin development
GO:0005524 ATP binding
GO:0006584 catecholamine metabolic process
GO:0010042 response to manganese ion
GO:0030424 axon
GO:0042415 norepinephrine metabolic process
GO:0006568 tryptophan metabolic process
GO:0010041 response to iron(III) ion
GO:0031252 cell leading edge
GO:0005770 late endosome
GO:0005829 cytosol
GO:0033162 melanosome membrane
GO:0034760 negative regulation of iron ion transmembrane transport
GO:0045793 positive regulation of cell size
GO:0060003 copper ion export
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0034220 ion transmembrane transport
GO:0048286 lung alveolus development
GO:0048812 neuron projection morphogenesis
GO:0051542 elastin biosynthetic process
GO:0005902 microvillus
GO:0016020 membrane
GO:0016532 superoxide dismutase copper chaperone activity
GO:0071276 cellular response to cadmium ion
GO:0071279 cellular response to cobalt ion
GO:0071281 cellular response to iron ion
GO:0014069 postsynaptic density
GO:0031526 brush border membrane
GO:0032767 copper-dependent protein binding
GO:0051216 cartilage development
GO:0051353 positive regulation of oxidoreductase activity
GO:1903036 positive regulation of response to wounding
GO:0005886 plasma membrane
GO:0010592 positive regulation of lamellipodium assembly
GO:0030199 collagen fibril organization
GO:0050679 positive regulation of epithelial cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:0005783 endoplasmic reticulum
GO:0043085 positive regulation of catalytic activity
GO:0010273 detoxification of copper ion
GO:0016323 basolateral plasma membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0021702 cerebellar Purkinje cell differentiation
GO:0043682 P-type divalent copper transporter activity
GO:0002082 regulation of oxidative phosphorylation
GO:0030141 secretory granule
GO:0031069 hair follicle morphogenesis
GO:0031267 small GTPase binding
GO:0042093 T-helper cell differentiation
GO:0043204 perikaryon
GO:0001974 blood vessel remodeling
GO:0021860 pyramidal neuron development
GO:0048023 positive regulation of melanin biosynthetic process
GO:1903136 cuprous ion binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Early endosome membrane
Endoplasmic reticulum
Golgi apparatus
Melanosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR006121 Heavy metal-associated domain, HMADomainDomain
IPR006122 Heavy metal-associated domain, copper ion-bindingDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR017969 Heavy-metal-associated, conserved siteSiteConserved site
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR027256 P-type ATPase, subfamily IBFamilyFamily
IPR036163 Heavy metal-associated domain superfamilyFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule