Entity Details

Primary name BTK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06187
EntryNameBTK_HUMAN
FullNameTyrosine-protein kinase BTK
TaxID9606
Evidenceevidence at protein level
Length659
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesBTK

GO terms

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GOName
GO:0001805 positive regulation of type III hypersensitivity
GO:0001812 positive regulation of type I hypersensitivity
GO:0001818 negative regulation of cytokine production
GO:0002250 adaptive immune response
GO:0002344 B cell affinity maturation
GO:0002553 histamine secretion by mast cell
GO:0002721 regulation of B cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007498 mesoderm development
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0030889 negative regulation of B cell proliferation
GO:0031410 cytoplasmic vesicle
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045579 positive regulation of B cell differentiation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0050853 B cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071226 cellular response to molecule of fungal origin
GO:0097190 apoptotic signaling pathway
GO:0098761 cellular response to interleukin-7

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001562 Zinc finger, Btk motifSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035574 Tyrosine-protein kinase BTK, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB01863 Inositol 1,3,4,5-TetrakisphosphateDrugbanksmall molecule
DB05204 XL418Drugbanksmall molecule
DB09053 IbrutinibDrugbanksmall molecule
DB11703 AcalabrutinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule
DB15327 AbivertinibDrugbanksmall molecule

Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
BTK_HUMANBTK_HUMANBioGRID, HPRD, IntAct, MINT10427990 11231015 11373296 11527964 11577348 11598012 12445832 12573241 29290977 8629002 8630736 details
BTK_HUMANBLNK_HUMANBioGRID, HPRD, MINT10498607 10556826 12093870 16969585 21482705 21822214 details
BTK_HUMAN3BP5_HUMANBioGRID, HPRD, IntAct10339589 9571151 details
BTK_HUMANGTF2I_HUMANBioGRID, HPRD, IntAct, MINT10373551 11313464 11373296 11934902 14623887 15096481 19214191 9012831 9837922 details
BTK_HUMANIBTK_HUMANBioGRID, HPRD, IntAct11577348 18596081 21482705 details
BTK_HUMANMED28_HUMANBioGRID, MINT16964398 details
BTK_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
BTK_HUMANGRB2_HUMANBioGRID, IntAct19380743 20936779 details
BTK_HUMANARRB1_HUMANBioGRID, IntAct21988832 details
BTK_HUMANUROK_HUMANBioGRID, IntAct21988832 details
BTK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
BTK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
BTK_HUMANMET_HUMANBioGRID, IntAct24728074 details
BTK_HUMANP55G_HUMANBioGRID, IntAct25814554 details
BTK_HUMANBECN1_HUMANBioGRID, IntAct25814554 details
BTK_HUMANRT22_HUMANBioGRID, IntAct25814554 details
BTK_HUMANWASP_HUMANbhf-ucl, BioGRID, HPRD10068673 10427990 12235133 12769846 8892607 9742969 details
BTK_HUMANMEOX2_HUMANBioGRID, IntAct25910212 details
BTK_HUMANGPVI_HUMANDIP19940238 details
BTK_HUMANADA15_HUMANUniProt25825872 details
BTK_HUMANKPCB_HUMANBioGRID, HPRD11598012 12679936 details
BTK_HUMANKPCD1_HUMANBioGRID, HPRD10561498 details
BTK_HUMANKHDR1_HUMANBioGRID, HPRD22745667 9201297 details
BTK_HUMANKS6B1_HUMANBioGRID16640565 details
BTK_HUMANKS6B2_HUMANBioGRID16640565 details
BTK_HUMANFYN_HUMANBioGRID8058772 details
BTK_HUMANLYN_HUMANBioGRID, HPRD11226282 11598012 8058772 8629002 8630736 details
BTK_HUMANHCK_HUMANBioGRID, HPRD8058772 details
BTK_HUMANRHG17_HUMANBioGRID, HPRD11431473 details
BTK_HUMANCBL_HUMANBioGRID, HPRD10427990 10826882 7629518 9408950 details
BTK_HUMANGNAQ_HUMANBioGRID, HPRD9770463 details
BTK_HUMANB2L11_HUMANBioGRID15096481 details
BTK_HUMANTLR8_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTLR4_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTLR6_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTLR9_HUMANBioGRID, HPRD12724322 details
BTK_HUMANA4_HUMANBioGRID21832049 details
BTK_HUMANSTA5A_HUMANBioGRID, HPRD11413148 7925280 8617237 details
BTK_HUMANSMUF1_HUMANBioGRID20804422 details
BTK_HUMANAURKA_HUMANBioGRID28218735 details
BTK_HUMANMDM2_HUMANBioGRID29290977 details
BTK_HUMANCOASY_HUMANBioGRID19763791 details
BTK_HUMANERBB3_HUMANBioGRID22973453 details
BTK_HUMANFCERG_HUMANIntAct11788586 details
BTK_HUMANKPCT_HUMANHPRD, IntAct11788586 details
BTK_HUMANARI3A_HUMANBioGRID, HPRD, MINT15203319 19214191 details
BTK_HUMANCD19_HUMANHPRD, MINT10201980 19214191 details
BTK_HUMANMAL_HUMANInnateDB22366891 details
BTK_HUMANHS90B_HUMANIntAct22939624 details
BTK_HUMANHS90A_HUMANBioGRID, IntAct22939624 28514442 details
BTK_HUMANCAV1_HUMANBioGRID, HPRD11751885 details
BTK_HUMANJAK1_HUMANBioGRID, HPRD9178903 details
BTK_HUMANVAV_HUMANBioGRID, HPRD9201297 details
BTK_HUMANEWS_HUMANBioGRID, HPRD9201297 details
BTK_HUMANPLCG2_HUMANBioGRID, HPRD10981967 11507089 12093870 17290227 details
BTK_HUMANCBLB_HUMANBioGRID12093870 details
BTK_HUMANMYD88_HUMANBioGRID, HPRD12724322 details
BTK_HUMANTIRAP_HUMANBioGRID, HPRD12724322 16415872 16439361 details
BTK_HUMANIRAK1_HUMANBioGRID, HPRD12724322 details
BTK_HUMANGBB1_HUMANBioGRID11698416 details
BTK_HUMANKSYK_HUMANBioGRID, HPRD10427990 11226282 11598012 8629002 8630736 details
BTK_HUMANCOR1C_HUMANBioGRID21080425 details
BTK_HUMANP53_HUMANBioGRID, HPRD15355990 32807901 details
BTK_HUMANITK_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
BTK_HUMANKPCZ_HUMANHPRD11788586 7522330 details
BTK_HUMANKPCE_HUMANHPRD11788586 7522330 details
BTK_HUMANKPCA_HUMANHPRD11788586 7522330 details
BTK_HUMANABL1_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
BTK_HUMANBMX_HUMANHPRD12573241 details
BTK_HUMANTEC_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
BTK_HUMANGNA12_HUMANHPRD9796816 details
BTK_HUMANWASF2_HUMANHPRD10427990 details
BTK_HUMANSH2B2_HUMANHPRD10872802 details
BTK_HUMANGBG2_HUMANHPRD11698416 7972043 details
BTK_HUMANDAPP1_HUMANHPRD11524430 details
BTK_HUMANTF65_HUMANHPRD15849198 details
BTK_HUMANKIT_HUMANHPRD15007095 details
BTK_HUMANPLCG1_HUMANHPRD15184383 details
BTK_HUMANPI42B_HUMANHPRD14614850 15046600 details
BTK_HUMANPI51A_HUMANHPRD14614850 15046600 details
BTK_HUMANTR10A_HUMANHPRD15007095 details
BTK_HUMANPI51C_HUMANHPRD14614850 15046600 details
BTK_HUMANBCAP_HUMANHPRD11163197 details
BTK_HUMANPI42A_HUMANHPRD14614850 15046600 details
BTK_HUMANPI42C_HUMANHPRD14614850 15046600 details
BTK_HUMANCKLF3_HUMANHPRD15087455 details
BTK_HUMANTNR6_HUMANHPRD9751072 details