Entity Details

Primary name B2CL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07817
EntryNameB2CL1_HUMAN
FullNameBcl-2-like protein 1
TaxID9606
Evidenceevidence at protein level
Length233
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesBCL2L1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001836 release of cytochrome c from mitochondria
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006897 endocytosis
GO:0007093 mitotic cell cycle checkpoint signaling
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0010507 negative regulation of autophagy
GO:0016021 integral component of membrane
GO:0019050 suppression by virus of host apoptotic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030672 synaptic vesicle membrane
GO:0031965 nuclear membrane
GO:0032465 regulation of cytokinesis
GO:0034097 response to cytokine
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
GO:0051607 defense response to virus
GO:0051881 regulation of mitochondrial membrane potential
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097136 Bcl-2 family protein complex
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1900118 negative regulation of execution phase of apoptosis
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903077 negative regulation of protein localization to plasma membrane
GO:2000811 negative regulation of anoikis
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Mitochondrion inner membrane
Mitochondrion matrix
Mitochondrion outer membrane
Nucleus membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4DomainDomain
IPR004725 Apoptosis regulator, Bcl-2/ BclXFamilyFamily
IPR013279 Apoptosis regulator, Bcl-XFamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07108 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACIDDrugbanksmall molecule
DB09401 IsosorbideDrugbanksmall molecule
DB13044 GossypolDrugbanksmall molecule

Interactions

134 interactions

InteractorPartnerSourcesPublicationsLink
B2CL1_HUMANPSN2_HUMANBioGRID, HPRD, MINT10446169 details
B2CL1_HUMANPSN1_HUMANBioGRID, HPRD, MINT10446169 details
B2CL1_HUMANBAD_HUMANBioGRID, HPRD, I2D, IntAct, MINT10611223 10620799 11077446 11206074 11483855 11494146 11583631 12115603 12137781 15131699 15694340 15705582 15721256 16697956 18628207 19427857 19667065 20603619 20837658 21988832 25241761 25416956 26186194 26264872 26871637 27684187 28514442 29997244 31467278 31515488 31980649 32296183 32814053 7834748 9305851 9388232 9389483 9824152 details
B2CL1_HUMANBAP31_HUMANBioGRID, HPRD, IntAct12594175 9334338 details
B2CL1_HUMANMK08_HUMANBioGRID, HPRD, IntAct, MINT15733859 22617334 25241761 details
B2CL1_HUMANFKBP8_HUMANBioGRID, HPRD, MINT12510191 15733859 details
B2CL1_HUMANB2CL1_HUMANBioGRID, HPRD, IntAct, MINT15131699 21856303 9111042 9130713 details
B2CL1_HUMANBAX_HUMANBioGRID, DIP, HPRD, IntAct, MINT11283018 12137781 12853473 14963330 15131699 16151013 17289999 17525735 18547146 18981409 19074440 19427863 21199865 21458670 21567405 21671007 21852238 24814347 25115399 25241761 26186194 26496610 27684187 28202514 28514442 28760928 29749471 32064756 9027312 9111042 9153240 9388232 9742125 9824152 details
B2CL1_HUMANBAK_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections10085290 11175750 12137781 14596824 15292519 15901672 16189514 17446862 19060904 20836993 22516262 23055042 23680104 26264872 29997244 31467278 31515488 32064756 32296183 32814053 9027312 details
B2CL1_HUMANB2L11_HUMANBioGRID, HPRD, IntAct, MINT10198631 11859372 14596824 15694340 15721256 16260615 16697956 17289999 17525735 19427863 20836993 21199865 21671007 22516262 23245996 26186194 27013495 28514442 32296183 9430630 9731710 details
B2CL1_HUMANHRK_HUMANBioGRID, HPRD, IntAct, UniProt10075695 14596824 15031724 15694340 15721256 16697956 9130713 details
B2CL1_HUMANBBC3_HUMANBioGRID, DIP, HPRD, IntAct15574335 15694340 15721256 16151013 16697956 17177603 19074266 22516262 27684187 28202514 details
B2CL1_HUMANBIK_HUMANBioGRID, DIP, HPRD, IntAct11342619 12853473 15694340 15721256 16189514 16697956 26871637 27107012 31515488 32296183 9027312 9525867 details
B2CL1_HUMANBID_HUMANBioGRID, DIP, HPRD, IntAct14963330 15574335 15694340 15721256 16697956 17289999 19074440 24814347 25241761 details
B2CL1_HUMANAPR_HUMANBioGRID, HPRD, IntAct10807576 15694340 15721256 21454712 details
B2CL1_HUMANP53_HUMANBioGRID, DIP, HPRD, IntAct, MINT12667443 14963330 16151013 20837658 21900206 24474649 24814347 25115399 26556313 30683842 32064756 details
B2CL1_HUMANPP1A_HUMANBioGRID, HPRD, IntAct12115603 17274640 details
B2CL1_HUMANPP1G_HUMANBioGRID, IntAct17274640 details
B2CL1_HUMANNLRP1_HUMANDIP, HPRD, IntAct17418785 19223583 details
B2CL1_HUMANBECN1_HUMANBioGRID, HPRD, MINT, UniProt17446862 18628207 18641390 19049976 19180116 19713971 20577262 22219388 22498477 24141421 24443581 9765397 details
B2CL1_HUMANSIVA_HUMANHPRD, UniProt12011449 14739602 details
B2CL1_HUMANBCL2_HUMANBioGRID, HPRD, IntAct11583631 12137781 14980220 18835031 26186194 28514442 details
B2CL1_HUMANCREB3_HUMANBioGRID, IntAct, MINT21516116 31515488 details
B2CL1_HUMANACTB_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANEDRF1_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANMET23_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANDOCK7_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANF16P1_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANGLOD4_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANLARP1_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANPDIA4_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANPLD3_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANPPHLN_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANPTN_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANRBM5_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANTLE1_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANASPP2_HUMANBioGRID, DIP, MINT18719108 21900206 details
B2CL1_HUMANUBR1_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANZFYV1_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANZHX1_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANZN219_HUMANBioGRID, MINT21900206 details
B2CL1_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
B2CL1_HUMANRAF1_HUMANBioGRID, IntAct25241761 8929532 details
B2CL1_HUMANBMF_HUMANBioGRID, HPRD, IntAct15694340 15721256 16260615 16697956 25416956 26871637 32296183 details
B2CL1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
B2CL1_HUMANGOLM1_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANTM50B_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANGNLY_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANG0S2_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANREEP4_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANCJ067_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANRNF4_HUMANBioGRID, IntAct29180619 32296183 details
B2CL1_HUMANRIC3_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANBNIP5_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANRHBD2_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANGORAB_HUMANBioGRID, IntAct32296183 details
B2CL1_HUMANMTOR_HUMANBioGRID, DIP, MINT20080789 26593251 details
B2CL1_HUMANSYUA_HUMANHPRD, IntAct11742726 32814053 details
B2CL1_HUMANAVEN_HUMANBioGRID, HPRD10949025 details
B2CL1_HUMANBNIP3_HUMANBioGRID, HPRD10625696 details
B2CL1_HUMANRTN1_HUMANBioGRID, HPRD11126360 details
B2CL1_HUMANRTN4_HUMANBioGRID, HPRD11126360 details
B2CL1_HUMANRAD9A_HUMANBioGRID, HPRD10620799 16189514 details
B2CL1_HUMANBBC3B_HUMANBioGRID, HPRD15574335 15694340 15721256 16697956 19074266 27684187 28202514 details
B2CL1_HUMANVDAC1_HUMANBioGRID, HPRD10365962 10737788 12767928 15637055 20080789 details
B2CL1_HUMANBNIPL_HUMANBioGRID12901880 details
B2CL1_HUMANBLK_HUMANBioGRID9525867 details
B2CL1_HUMANAPAF_HUMANBioGRID, HPRD12963020 9488720 9539746 details
B2CL1_HUMANIKZF3_HUMANBioGRID, HPRD11714801 details
B2CL1_HUMANSEC20_HUMANBioGRID, HPRD10217402 details
B2CL1_HUMANBLID_HUMANBioGRID20400521 details
B2CL1_HUMANPARK7_HUMANBioGRID21852238 details
B2CL1_HUMANCRYA2_HUMANBioGRID, HPRD14752512 details
B2CL1_HUMANCRYAA_HUMANBioGRID, HPRD14752512 details
B2CL1_HUMANCRYAB_HUMANBioGRID, HPRD14752512 details
B2CL1_HUMANAKT1_HUMANBioGRID16282323 details
B2CL1_HUMANPRKN_HUMANBioGRID24999239 28038320 32088314 details
B2CL1_HUMANPINK1_HUMANBioGRID24999239 32088314 details
B2CL1_HUMANTCTP_HUMANBioGRID15870695 details
B2CL1_HUMANCDN2A_HUMANBioGRID19049976 details
B2CL1_HUMANARF_HUMANBioGRID19049976 details
B2CL1_HUMANBNI3L_HUMANBioGRID, HPRD10467396 9973195 details
B2CL1_HUMANPLK1_HUMANBioGRID22617334 details
B2CL1_HUMANMK09_HUMANBioGRID22617334 details
B2CL1_HUMANGSK3A_HUMANBioGRID22617334 details
B2CL1_HUMANGSK3B_HUMANBioGRID22617334 details
B2CL1_HUMANMAPK2_HUMANBioGRID22617334 details
B2CL1_HUMANMK14_HUMANBioGRID22617334 details
B2CL1_HUMANCHK1_HUMANBioGRID22617334 details
B2CL1_HUMANAURKA_HUMANBioGRID22617334 details
B2CL1_HUMANPLK3_HUMANBioGRID22617334 details
B2CL1_HUMANVAC14_HUMANBioGRID26871637 details
B2CL1_HUMANB2L12_HUMANBioGRID, HPRD11283018 29749471 details
B2CL1_HUMANRN183_HUMANBioGRID29507230 details
B2CL1_HUMANRYR3_HUMANBioGRID25872771 details
B2CL1_HUMANUBC9_HUMANBioGRID32296183 details
B2CL1_HUMANBCLF1_HUMANHPRD10330179 details
B2CL1_HUMANABL1_HUMANBioGRID, MINT16631755 details
B2CL1_HUMANSPNS1_HUMANBioGRID, HPRD, UniProt12815463 details
B2CL1_HUMANDNM1L_HUMANDIP18250306 23792689 details
B2CL1_HUMANCLUS_HUMANBioGRID, IntAct21527247 21567405 details
B2CL1_HUMANVRK2_HUMANIntAct23449449 details
B2CL1_HUMANCYC_HUMANBioGRID, HPRD, IntAct25241761 9192670 details
B2CL1_HUMANCASP9_HUMANBioGRID, HPRD, IntAct25241761 9539746 details
B2CL1_HUMANBOP_HUMANIntAct23055042 details
B2CL1_HUMANCASP8_HUMANDIP, HPRD11733517 9027312 details
B2CL1_HUMANB2L14_HUMANBioGRID, HPRD11054413 details
B2CL1_HUMANIRS1_HUMANBioGRID, HPRD10679027 details
B2CL1_HUMANMOAP1_HUMANBioGRID, HPRD11060313 details
B2CL1_HUMANMCL1_HUMANBioGRID, HPRD10837489 15077116 details
B2CL1_HUMANCFLAR_HUMANBioGRID, HPRD9326610 details
B2CL1_HUMANDYL1_HUMANBioGRID10198631 details
B2CL1_HUMANPGAM5_HUMANBioGRID17046835 details
B2CL1_HUMANBFAR_HUMANBioGRID10716992 details
B2CL1_HUMANATX3_HUMANBioGRID23562578 details
B2CL1_HUMANCASP1_HUMANBioGRID, HPRD9027312 9435230 details
B2CL1_HUMANC8AP2_HUMANBioGRID9027312 details
B2CL1_HUMANGIMA5_HUMANBioGRID16509771 details
B2CL1_HUMANATG5_HUMANBioGRID16998475 details
B2CL1_HUMANUBP14_HUMANBioGRID25429837 26710889 details
B2CL1_HUMANCDK1_HUMANBioGRID22617334 details
B2CL1_HUMANUBP18_HUMANBioGRID28709980 details
B2CL1_HUMANMID51_HUMANBioGRID30894073 details
B2CL1_HUMANMIDUO_HUMANBioGRID30894073 details
B2CL1_HUMANLFG2_HUMANBioGRID26582200 details
B2CL1_HUMANBI1_HUMANHPRD9660918 details
B2CL1_HUMANIRS2_HUMANHPRD10679027 details
B2CL1_HUMANBAG1_HUMANHPRD10467399 details
B2CL1_HUMANANTR1_HUMANHPRD11574549 details
B2CL1_HUMANB2L10_HUMANHPRD11278245 details
B2CL1_HUMANCAN1_HUMANHPRD12000759 details