Entity Details

Primary name ABCC8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ09428
EntryNameABCC8_HUMAN
FullNameATP-binding cassette sub-family C member 8
TaxID9606
Evidenceevidence at protein level
Length1581
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesABCC8

GO terms

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GOName
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006813 potassium ion transport
GO:0008281 sulfonylurea receptor activity
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0031004 potassium ion-transporting ATPase complex
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0044325 transmembrane transporter binding
GO:0050796 regulation of insulin secretion
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:0098662 inorganic cation transmembrane transport

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000388 Sulphonylurea receptorFamilyFamily
IPR000844 ATP-binding cassette subfamily C member 8FamilyFamily
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00222 GlimepirideDrugbanksmall molecule
DB00672 ChlorpropamideDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00839 TolazamideDrugbanksmall molecule
DB00912 RepaglinideDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01067 GlipizideDrugbanksmall molecule
DB01120 GliclazideDrugbanksmall molecule
DB01124 TolbutamideDrugbanksmall molecule
DB01251 GliquidoneDrugbanksmall molecule
DB01252 MitiglinideDrugbanksmall molecule
DB01382 GlymidineDrugbanksmall molecule