Entity Details

Primary name DLG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12959
EntryNameDLG1_HUMAN
FullNameDisks large homolog 1
TaxID9606
Evidenceevidence at protein level
Length904
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDLG1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001771 immunological synapse formation
GO:0001772 immunological synapse
GO:0001935 endothelial cell proliferation
GO:0002088 lens development in camera-type eye
GO:0004385 guanylate kinase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005604 basement membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007268 chemical synaptic transmission
GO:0008022 protein C-terminus binding
GO:0008092 cytoskeletal protein binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009898 cytoplasmic side of plasma membrane
GO:0014704 intercalated disc
GO:0015459 potassium channel regulator activity
GO:0016032 viral process
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030054 cell junction
GO:0030432 peristalsis
GO:0030838 positive regulation of actin filament polymerization
GO:0030866 cortical actin cytoskeleton organization
GO:0030953 astral microtubule organization
GO:0031253 cell projection membrane
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031579 membrane raft organization
GO:0031594 neuromuscular junction
GO:0031641 regulation of myelination
GO:0032147 activation of protein kinase activity
GO:0033268 node of Ranvier
GO:0034629 cellular protein-containing complex localization
GO:0035748 myelin sheath abaxonal region
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0042383 sarcolemma
GO:0042391 regulation of membrane potential
GO:0042982 amyloid precursor protein metabolic process
GO:0043005 neuron projection
GO:0043113 receptor clustering
GO:0043219 lateral loop
GO:0043268 positive regulation of potassium ion transport
GO:0043622 cortical microtubule organization
GO:0044325 transmembrane transporter binding
GO:0045121 membrane raft
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045296 cadherin binding
GO:0048471 perinuclear region of cytoplasm
GO:0048608 reproductive structure development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048745 smooth muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051660 establishment of centrosome localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060022 hard palate development
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070830 bicellular tight junction assembly
GO:0072659 protein localization to plasma membrane
GO:0097016 L27 domain binding
GO:0097025 MPP7-DLG1-LIN7 complex
GO:0097060 synaptic membrane
GO:0097120 receptor localization to synapse
GO:0098609 cell-cell adhesion
GO:0098839 postsynaptic density membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:0098919 structural constituent of postsynaptic density
GO:0098978 glutamatergic synapse
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902473 regulation of protein localization to synapse
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903286 regulation of potassium ion import
GO:1903753 negative regulation of p38MAPK cascade
GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1903764 regulation of potassium ion export across plasma membrane
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell junction
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Membrane

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR004172 L27 domainDomainDomain
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR015143 L27-1DomainDomain
IPR016313 Disks large 1-likeFamilyFamily
IPR019583 PDZ-associated domain of NMDA receptorsDomainDomain
IPR019590 Disks large homologue 1, N-terminal PEST domainDomainDomain
IPR020590 Guanylate kinase, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036892 L27 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

142 interactions

InteractorPartnerSourcesPublicationsLink
DLG1_HUMANKCNA3_HUMANBioGRID, HPRD, MINT7477295 9341123 details
DLG1_HUMANLCK_HUMANBioGRID, HPRD, IntAct, MINT25241761 9341123 details
DLG1_HUMANTOPK_HUMANHPRD, MINT10779557 details
DLG1_HUMANKI13B_HUMANBioGRID, HPRD, IntAct10859302 details
DLG1_HUMANKIF1B_HUMANBioGRID, HPRD, IntAct, MINT12097473 24550280 29395067 details
DLG1_HUMANADA17_HUMANBioGRID, HPRD, MINT12668732 18930083 details
DLG1_HUMANAT2B2_HUMANBioGRID, HPRD, IntAct11274188 details
DLG1_HUMANASAP1_HUMANMINT16636290 details
DLG1_HUMANANO9_HUMANIntAct, MINT21525870 24550280 details
DLG1_HUMANCLTR2_HUMANIntAct, MINT21525870 24550280 26617989 30126976 details
DLG1_HUMANMP2K2_HUMANMINT21615688 details
DLG1_HUMANMK12_HUMANBioGRID, HPRD, IntAct16637659 25241761 27416801 30126976 details
DLG1_HUMANFBW1A_HUMANBioGRID, IntAct12902344 details
DLG1_HUMANAGRA2_HUMANBioGRID, IntAct, MINT15021905 24550280 details
DLG1_HUMANAGRA3_HUMANHPRD, IntAct, MINT15021905 24550280 details
DLG1_HUMANKCNA5_HUMANBioGRID, HPRD, MINT12970345 16466689 24550280 details
DLG1_HUMANCTND2_HUMANIntAct, MINT24550280 30126976 details
DLG1_HUMANNXPE2_HUMANMINT24550280 details
DLG1_HUMANRBP1_HUMANBioGRID, IntAct, MINT24550280 30126976 31980649 details
DLG1_HUMANEXOC4_HUMANMINT24550280 details
DLG1_HUMANRASF6_HUMANMINT24550280 details
DLG1_HUMANFRPD4_HUMANIntAct, MINT24550280 30126976 details
DLG1_HUMANSO1C1_HUMANMINT24550280 details
DLG1_HUMANSCN5A_HUMANHPRD, MINT16637659 24550280 details
DLG1_HUMANNMDE2_HUMANBioGRID, HPRD, IntAct, MINT11997254 24550280 30126976 8601796 details
DLG1_HUMANPRR5_HUMANIntAct, MINT24550280 30126976 details
DLG1_HUMANRNF12_HUMANMINT24550280 details
DLG1_HUMANPKP4_HUMANIntAct, MINT24550280 30126976 details
DLG1_HUMANIQEC1_HUMANMINT24550280 details
DLG1_HUMANZSC30_HUMANMINT24550280 details
DLG1_HUMANPL8L1_HUMANMINT24550280 details
DLG1_HUMANERBB4_HUMANBioGRID, HPRD, MINT12175853 24550280 details
DLG1_HUMANDCNL1_HUMANMINT24550280 details
DLG1_HUMANF163A_HUMANMINT24550280 details
DLG1_HUMANMARH3_HUMANMINT24550280 details
DLG1_HUMANARHG8_HUMANBioGRID, IntAct, MINT17938206 19586902 24550280 30126976 32203420 details
DLG1_HUMANF163B_HUMANIntAct, MINT24550280 30126976 details
DLG1_HUMANTBX15_HUMANMINT24550280 details
DLG1_HUMANCRIPT_HUMANBioGRID, HPRD, MINT12070168 18951956 24550280 details
DLG1_HUMANAGRA1_HUMANMINT24550280 details
DLG1_HUMANKCNA4_HUMANBioGRID, HPRD, MINT11997254 12860415 24550280 7477295 8938729 details
DLG1_HUMANKCJ12_HUMANBioGRID, HPRD, MINT11181181 14960569 15024025 24550280 5024025 details
DLG1_HUMANEZRI_HUMANBioGRID, HPRD, IntAct11726633 29568061 34079125 details
DLG1_HUMANCRCM_HUMANIntAct30126976 details
DLG1_HUMANKS6A2_HUMANIntAct30126976 details
DLG1_HUMANTANC1_HUMANHPRD, IntAct15673434 30126976 details
DLG1_HUMANADA22_HUMANIntAct30126976 details
DLG1_HUMANANO2_HUMANIntAct30126976 details
DLG1_HUMANNMDE3_HUMANIntAct30126976 details
DLG1_HUMANEVI5_HUMANIntAct30126976 details
DLG1_HUMANWDR20_HUMANIntAct30126976 details
DLG1_HUMANCAHM3_HUMANIntAct30126976 details
DLG1_HUMANCRFR1_HUMANBioGRID, IntAct23576434 30126976 details
DLG1_HUMANARHGG_HUMANBioGRID, IntAct30126976 32203420 details
DLG1_HUMANS14L3_HUMANIntAct30126976 details
DLG1_HUMANGCYA2_HUMANBioGRID, HPRD, IntAct11572861 30126976 details
DLG1_HUMANMOT4_HUMANIntAct30126976 details
DLG1_HUMANIQEC2_HUMANIntAct30126976 details
DLG1_HUMANVANG2_HUMANIntAct30126976 details
DLG1_HUMANVANG1_HUMANIntAct30126976 details
DLG1_HUMANHTR5B_HUMANIntAct30126976 details
DLG1_HUMANAPC_HUMANIntAct23185543 30126976 details
DLG1_HUMANMTMR1_HUMANIntAct30126976 details
DLG1_HUMANNMDE4_HUMANIntAct30126976 details
DLG1_HUMANRAPSN_HUMANIntAct30126976 details
DLG1_HUMANPABP2_HUMANIntAct30126976 details
DLG1_HUMANLRR3C_HUMANIntAct30126976 details
DLG1_HUMANCD1D_HUMANIntAct30126976 details
DLG1_HUMANRT34_HUMANHPRD, IntAct12507520 30126976 details
DLG1_HUMANSSBP2_HUMANIntAct30126976 details
DLG1_HUMANTPBGL_HUMANIntAct30126976 details
DLG1_HUMAN5HT2C_HUMANIntAct30126976 details
DLG1_HUMANEAA3_HUMANIntAct30126976 details
DLG1_HUMANKCJ18_HUMANIntAct30126976 details
DLG1_HUMANKCNJ2_HUMANBioGRID, HPRD, IntAct11181181 30126976 details
DLG1_HUMANT178A_HUMANIntAct30126976 details
DLG1_HUMANDB116_HUMANIntAct30126976 details
DLG1_HUMANADA10_HUMANBioGRID, UniProt17301176 25036101 details
DLG1_HUMANKCNJ4_HUMANBioGRID, HPRD11181181 14960569 15024025 details
DLG1_HUMANCSKP_HUMANBioGRID, HPRD10993877 12151521 12351654 14960569 23864692 25852190 details
DLG1_HUMANNMDE1_HUMANBioGRID, HPRD10336672 12933808 8601796 details
DLG1_HUMANKCC2A_HUMANBioGRID12933808 details
DLG1_HUMANGRIA1_HUMANBioGRID, HPRD11567040 12933808 23864692 9677374 details
DLG1_HUMANEPB41_HUMANBioGRID, HPRD7937897 details
DLG1_HUMANAT2B4_HUMANBioGRID, HPRD11274188 12511555 details
DLG1_HUMANDLGP1_HUMANBioGRID, HPRD11060025 9024696 9115257 9286858 details
DLG1_HUMANKCNJ6_HUMANBioGRID, HPRD10619846 details
DLG1_HUMANTJAP1_HUMANBioGRID, HPRD11602598 details
DLG1_HUMANLRRC1_HUMANBioGRID, HPRD11440998 details
DLG1_HUMANUBE3A_HUMANBioGRID16482544 details
DLG1_HUMANKHDR1_HUMANBioGRID22745667 details
DLG1_HUMANAGRB1_HUMANBioGRID23782696 details
DLG1_HUMANTGFA_HUMANBioGRID18930083 details
DLG1_HUMANPTEN_HUMANBioGRID, HPRD10646847 11439092 11707428 details
DLG1_HUMANDLG1_HUMANBioGRID, HPRD10788497 11602598 details
DLG1_HUMANNMDZ1_HUMANBioGRID23864692 details
DLG1_HUMAN5HT2A_HUMANBioGRID24989932 details
DLG1_HUMANSSR1_HUMANBioGRID18951956 details
DLG1_HUMANLRP2_HUMANHPRD12713445 details
DLG1_HUMANMYO6_HUMANHPRD12050163 details
DLG1_HUMANBEGIN_HUMANHPRD9756850 details
DLG1_HUMANSEM4C_HUMANHPRD11134026 details
DLG1_HUMANDLGP4_HUMANHPRD9115257 details
DLG1_HUMANFZD7_HUMANHPRD12067714 details
DLG1_HUMANFZD4_HUMANHPRD12067714 details
DLG1_HUMANWNT3A_HUMANHPRD12067714 details
DLG1_HUMANKCNA1_HUMANHPRD7477295 details
DLG1_HUMANKCNA2_HUMANHPRD7477295 details
DLG1_HUMANDLGP3_HUMANHPRD9115257 details
DLG1_HUMANM3K3_HUMANIntAct14743216 details
DLG1_HUMANPRKN_HUMANBioGRID, HPRD, IntAct16637659 25241761 details
DLG1_HUMANLIN7A_HUMANBioGRID, IntAct14960569 24366813 details
DLG1_HUMANDLG3_HUMANBioGRID, HPRD, IntAct12351654 26496610 details
DLG1_HUMANLIN7C_HUMANBioGRID, IntAct14960569 26186194 28514442 details
DLG1_HUMANAPBA1_HUMANBioGRID14960569 details
DLG1_HUMANACTN2_HUMANBioGRID, HPRD12860415 details
DLG1_HUMANCCG2_HUMANBioGRID, HPRD11140673 16637659 details
DLG1_HUMANGRIK2_HUMANBioGRID, HPRD11279111 9808460 details
DLG1_HUMANCTNA1_HUMANBioGRID, HPRD9512503 details
DLG1_HUMANMARH2_HUMANBioGRID17980554 details
DLG1_HUMANKCNC1_HUMANBioGRID19213956 details
DLG1_HUMANMAP1A_HUMANBioGRID, HPRD9786987 details
DLG1_HUMANMPP2_HUMANBioGRID, HPRD12351654 28514442 details
DLG1_HUMANCXB1_HUMANBioGRID30401746 details
DLG1_HUMANSTX4_HUMANBioGRID, HPRD18793635 34079125 details
DLG1_HUMANKCAB1_HUMANHPRD9341123 details
DLG1_HUMANKCJ10_HUMANHPRD9148889 details
DLG1_HUMANDLG2_HUMANHPRD12351654 details
DLG1_HUMANAKAP5_HUMANHPRD10939335 details
DLG1_HUMANGUAD_HUMANHPRD10595517 details
DLG1_HUMANCALM1_HUMANHPRD12189141 details
DLG1_HUMANCALM2_HUMANHPRD12189141 details
DLG1_HUMANCALM3_HUMANHPRD12189141 details
DLG1_HUMANACTS_HUMANHPRD9512503 details
DLG1_HUMANWASP_HUMANHPRD15699074 details
DLG1_HUMANGBG13_HUMANHPRD16473877 details
DLG1_HUMANSCN4A_HUMANHPRD16637659 details
DLG1_HUMANCNKR2_HUMANHPRD16637659 details
DLG1_HUMANGLSL_HUMANHPRD16637659 details
DLG1_HUMANPAX6_HUMANHPRD16637659 details
DLG1_HUMANBCR_HUMANHPRD16825666 details
DLG1_HUMANADRB1_HUMANHPRD16316992 details