Entity Details

Primary name IRAK3
Entity type gene
Source Source Link

Details

PrimaryID11213
RefseqGeneNG_021194
SymbolIRAK3
Nameinterleukin 1 receptor associated kinase 3
Chromosome12
Location12q14.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-09
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsIRAK3_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0009615 response to virus
GO:0010933 positive regulation of macrophage tolerance induction
GO:0010936 negative regulation of macrophage cytokine production
GO:0019221 cytokine-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0042177 negative regulation of protein catabolic process
GO:0042803 protein homodimerization activity
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0043244 regulation of protein-containing complex disassembly
GO:0043330 response to exogenous dsRNA
GO:0043407 negative regulation of MAP kinase activity
GO:0045824 negative regulation of innate immune response
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Diseases

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Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
IRAK3TRAF6BioGRID, HPRD, IntAct, MINT10383454 32296183 details
IRAK3IRAK1BioGRID, HPRD, IntAct, MINT10383454 12138165 19166926 21903422 details
IRAK3ATP6V0BBioGRID, IntAct21988832 details
IRAK3COPB1BioGRID, IntAct21988832 details
IRAK3ECM1BioGRID, IntAct21988832 details
IRAK3FOLR1BioGRID, IntAct21988832 details
IRAK3CDCA5BioGRID, IntAct21988832 details
IRAK3ADH1BBioGRID, IntAct21988832 details
IRAK3CD14BioGRID, IntAct21988832 details
IRAK3HOXB7BioGRID, IntAct21988832 details
IRAK3NONOBioGRID, IntAct21988832 details
IRAK3NTRK3BioGRID, IntAct21988832 details
IRAK3LDB1BioGRID, IntAct21988832 details
IRAK3NSA2BioGRID, IntAct21988832 details
IRAK3MYD88BioGRID, HPRD, MINT10383454 details
IRAK3IRAK3HPRD, MINT10383454 details
IRAK3IRAK2BioGRID, HPRD, IntAct, MINT10383454 21903422 details
IRAK3HSP90AB1IntAct22939624 details
IRAK3STAT3IntAct27150039 details
IRAK3RNF152BioGRID31930677 details
IRAK3GSDMDBioGRID32597834 details
IRAK3TICAM2HPRD12721283 details
IRAK3KRT8BioGRID, IntAct30021884 details
IRAK3KRT18BioGRID, IntAct30021884 details
IRAK3IRAK4BioGRID21903422 details
IRAK3HSP90AA1BioGRID22939624 details
IRAK3NR3C1BioGRID31182584 details