Entity Details

Primary name MTAP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13126
EntryNameMTAP_HUMAN
FullNameS-methyl-5'-thioadenosine phosphorylase
TaxID9606
Evidenceevidence at protein level
Length283
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMTAP

GO terms

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GOName
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006139 nucleobase-containing compound metabolic process
GO:0006166 purine ribonucleoside salvage
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
GO:0019509 L-methionine salvage from methylthioadenosine
GO:0033574 response to testosterone
GO:0035722 interleukin-12-mediated signaling pathway
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000845 Nucleoside phosphorylase domainDomainDomain
IPR010044 Methylthioadenosine phosphorylase (MTAP)FamilyFamily
IPR018099 Purine phosphorylase, family 2, conserved siteSiteConserved site
IPR035994 Nucleoside phosphorylase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00173 AdenineDrugbanksmall molecule
DB02158 (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediolDrugbanksmall molecule
DB02281 FormycinDrugbanksmall molecule
DB02282 5'-S-methyl-5'-thioadenosineDrugbanksmall molecule
DB02933 5'-Deoxy-5'-(Methylthio)-TubercidinDrugbanksmall molecule