Entity Details

Primary name AKR1C2
Entity type gene
Source Source Link

Details

PrimaryID1646
RefseqGeneNG_031852
SymbolAKR1C2
Namealdo-keto reductase family 1 member C2
Chromosome10
Location10p15.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsAK1C2_HUMAN

GO terms

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GOName
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0005829 cytosol
GO:0006693 prostaglandin metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007586 digestion
GO:0008202 steroid metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0016229 steroid dehydrogenase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 phenanthrene 9,10-monooxygenase activity
GO:0030855 epithelial cell differentiation
GO:0031406 carboxylic acid binding
GO:0032052 bile acid binding
GO:0042448 progesterone metabolic process
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0047023 androsterone dehydrogenase activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0047086 ketosteroid monooxygenase activity
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047718 indanol dehydrogenase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0071395 cellular response to jasmonic acid stimulus
GO:0071799 cellular response to prostaglandin D stimulus
GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity

Diseases

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Disease IDSourceNameDescription
614279 OMIM46,XY sex reversal 8 (SRXY8)A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. The disease is caused by variants affecting the gene represented in this entry.