Entity Details

Primary name EXOS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13868
EntryNameEXOS2_HUMAN
FullNameExosome complex component RRP4
TaxID9606
Evidenceevidence at protein level
Length293
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesEXOSC2

GO terms

Show/Hide Table
GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0008312 7S RNA binding
GO:0030307 positive regulation of cell growth
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0034475 U4 snRNA 3'-end processing
GO:0043488 regulation of mRNA stability
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0071034 CUT catabolic process
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
GO:0071049 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR004088 K Homology domain, type 1DomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR025721 Exosome complex component, N-terminal domainDomainDomain
IPR026699 Exosome complex RNA-binding protein 1/RRP40/RRP4FamilyFamily
IPR036612 K Homology domain, type 1 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
617763 OMIMShort stature, hearing loss, retinitis pigmentosa, and distinctive facies (SHRF)An autosomal recessive disorder characterized by childhood myopia, early onset retinitis pigmentosa, progressive sensorineural hearing loss, hypothyroidism, short stature, brachydactyly, recognisable facial gestalt, premature ageing and mild intellectual disability. The disease is caused by variants affecting the gene represented in this entry.

Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
EXOS2_HUMANEXOS7_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12419256 15231747 24981860 26186194 26344197 26496610 27173435 28514442 unassigned1312 details
EXOS2_HUMANZN408_HUMANBioGRID, HPRD, IntAct15231747 details
EXOS2_HUMANRNF8_HUMANBioGRID, HPRD, IntAct15231747 details
EXOS2_HUMANEXOS4_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11719186 12419256 17545563 20531386 22939629 24981860 26344197 26496610 27173435 unassigned1312 details
EXOS2_HUMANEXOS9_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12788944 17412707 17545563 22939629 24981860 26344197 26496610 27173435 unassigned1312 details
EXOS2_HUMANMPH6_HUMANBioGRID, UniProt11719186 16396833 24981860 26344197 26496610 28877463 details
EXOS2_HUMANSBK3_HUMANBioGRID, IntAct32296183 details
EXOS2_HUMANGLT13_HUMANBioGRID15231747 details
EXOS2_HUMANSIA7A_HUMANBioGRID15231747 details
EXOS2_HUMANRM48_HUMANBioGRID15231747 details
EXOS2_HUMANPTEN_HUMANBioGRID31685992 details
EXOS2_HUMANRENT1_HUMANBioGRID, HPRD, IntAct14527413 18423202 details
EXOS2_HUMANEXOS3_HUMANBioGRID, IntAct, MINT, UniProt11719186 16396833 17545563 20531389 21255825 22939629 24981860 26186194 26344197 26496610 28514442 32188736 details
EXOS2_HUMANDI3L1_HUMANBioGRID, IntAct, MINT20531386 20531389 24981860 26496610 details
EXOS2_HUMANRRP44_HUMANBioGRID, HPRD, MINT11719186 20531386 26344197 details
EXOS2_HUMANFUBP2_HUMANBioGRID, HPRD, UniProt11719186 15175153 details
EXOS2_HUMANDHYS_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANLUM_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANLRC47_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANSLIT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANRSRC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS2_HUMANRENT2_HUMANBioGRID14527413 details
EXOS2_HUMANREN3A_HUMANBioGRID14527413 details
EXOS2_HUMANMET22_HUMANBioGRID23349634 details
EXOS2_HUMANTISB_HUMANBioGRID18326031 details
EXOS2_HUMANOSTM1_HUMANBioGRID32188736 details
EXOS2_HUMANPALS2_HUMANHPRD11719186 details