Entity Details

Primary name BMPR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13873
EntryNameBMPR2_HUMAN
FullNameBone morphogenetic protein receptor type-2
TaxID9606
Evidenceevidence at protein level
Length1038
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesBMPR2

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001707 mesoderm formation
GO:0001893 maternal placenta development
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0002063 chondrocyte development
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003183 mitral valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis
GO:0004674 protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0005912 adherens junction
GO:0006468 protein phosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420 brain development
GO:0009267 cellular response to starvation
GO:0009925 basal plasma membrane
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014069 postsynaptic density
GO:0014916 regulation of lung blood pressure
GO:0016324 apical plasma membrane
GO:0019838 growth factor binding
GO:0030166 proteoglycan biosynthetic process
GO:0030308 negative regulation of cell growth
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0036122 BMP binding
GO:0042127 regulation of cell population proliferation
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0044214 spanning component of plasma membrane
GO:0045296 cadherin binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045906 negative regulation of vasoconstriction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048286 lung alveolus development
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0051148 negative regulation of muscle cell differentiation
GO:0060173 limb development
GO:0060350 endochondral bone morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061036 positive regulation of cartilage development
GO:0061298 retina vasculature development in camera-type eye
GO:0061626 pharyngeal arch artery morphogenesis
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0072577 endothelial cell apoptotic process
GO:0098821 BMP receptor activity
GO:1902731 negative regulation of chondrocyte proliferation
GO:1905314 semi-lunar valve development
GO:1990782 protein tyrosine kinase binding
GO:2000279 negative regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015770 Bone morphogenetic protein receptor type-2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB11639 Dibotermin alfaDrugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule

Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
BMPR2_HUMANGDF5_HUMANBioGRID, HPRD, MINT19229295 9525338 details
BMPR2_HUMANMK08_HUMANBioGRID, MINT21900206 details
BMPR2_HUMANHSC20_HUMANDIP24606901 details
BMPR2_HUMANACVR1_HUMANBioGRID, IntAct28514442 7791754 7890683 details
BMPR2_HUMANBMP2_HUMANBioGRID, DIP, HPRD10712517 10880444 25938661 7791754 details
BMPR2_HUMANLIMK1_HUMANBioGRID, HPRD12963706 details
BMPR2_HUMANTGFR1_HUMANBioGRID7791754 7890683 details
BMPR2_HUMANACV1B_HUMANBioGRID7791754 details
BMPR2_HUMANTSR1_HUMANBioGRID7791754 details
BMPR2_HUMANBMP7_HUMANBioGRID, HPRD7644468 7791754 details
BMPR2_HUMANGDF6_HUMANBioGRID, HPRD9525338 details
BMPR2_HUMANBMP4_HUMANBioGRID, HPRD12045205 28126904 7644468 8702914 details
BMPR2_HUMANGDF9_HUMANBioGRID, HPRD12135884 details
BMPR2_HUMANFHL2_HUMANBioGRID19265191 details
BMPR2_HUMANTRIB3_HUMANBioGRID17576816 details
BMPR2_HUMANPP1G_HUMANBioGRID23080069 details
BMPR2_HUMANGDF2_HUMANBioGRID17311849 22718755 details
BMPR2_HUMANBMP10_HUMANBioGRID22718755 details
BMPR2_HUMANTDGF1_HUMANBioGRID28126904 details
BMPR2_HUMANINHBB_HUMANBioGRID28126904 details
BMPR2_HUMANKIT_HUMANBioGRID16155937 details
BMPR2_HUMANSMUF1_HUMANBioGRID31578224 details
BMPR2_HUMANDYLT1_HUMANBioGRID, HPRD14583445 31578224 details
BMPR2_HUMANKGP1_HUMANMINT19424179 details
BMPR2_HUMANBMR1A_HUMANBioGRID, HPRD10712517 7791754 details
BMPR2_HUMANBMR1B_HUMANBioGRID, HPRD10712517 7791754 details
BMPR2_HUMANBMP6_HUMANBioGRID, HPRD10504300 11401330 details
BMPR2_HUMANBMPR2_HUMANBioGRID, HPRD10712517 details
BMPR2_HUMANXIAP_HUMANBioGRID19782107 details
BMPR2_HUMANFST_HUMANBioGRID16198295 details
BMPR2_HUMANSMAD6_HUMANBioGRID20663871 details
BMPR2_HUMANSMAD7_HUMANBioGRID20663871 details
BMPR2_HUMANCAV1_HUMANBioGRID15657086 details
BMPR2_HUMANEGLN_HUMANBioGRID23967299 details
BMPR2_HUMANAVR2A_HUMANBioGRID23967299 details
BMPR2_HUMANCADH5_HUMANBioGRID26598555 details
BMPR2_HUMANKPCB_HUMANHPRD15188402 details
BMPR2_HUMANMOS_HUMANHPRD15188402 details
BMPR2_HUMANTBB2A_HUMANHPRD15188402 details
BMPR2_HUMANM3K8_HUMANHPRD15188402 details
BMPR2_HUMANLMX1A_HUMANHPRD15188402 details
BMPR2_HUMANPGTA_HUMANHPRD15188402 details
BMPR2_HUMANCTBP1_HUMANHPRD15188402 details
BMPR2_HUMANTBB4A_HUMANHPRD15188402 details
BMPR2_HUMANMERTK_HUMANHPRD15188402 details
BMPR2_HUMANNBEA_HUMANHPRD15188402 details
BMPR2_HUMANHNRPR_HUMANHPRD15188402 details
BMPR2_HUMANFOXL1_HUMANHPRD15188402 details
BMPR2_HUMANMPPA_HUMANHPRD15188402 details
BMPR2_HUMANOC90_HUMANHPRD15188402 details
BMPR2_HUMANCCD89_HUMANHPRD15188402 details
BMPR2_HUMANST1E1_HUMANHPRD15188402 details
BMPR2_HUMANARSA_HUMANHPRD15188402 details
BMPR2_HUMANARP8_HUMANHPRD15188402 details
BMPR2_HUMANNOP56_HUMANHPRD15188402 details
BMPR2_HUMANTWF1_HUMANHPRD15188402 details
BMPR2_HUMANTRPC1_HUMANHPRD15188402 details
BMPR2_HUMANLSM10_HUMANHPRD15188402 details
BMPR2_HUMANPZRN3_HUMANHPRD15188402 details
BMPR2_HUMANTOPB1_HUMANHPRD15188402 details
BMPR2_HUMANEST1_HUMANHPRD15188402 details
BMPR2_HUMANC4BPA_HUMANHPRD15188402 details
BMPR2_HUMANLSP1_HUMANHPRD15188402 details