Entity Details

Primary name LRP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14114
EntryNameLRP8_HUMAN
FullNameLow-density lipoprotein receptor-related protein 8
TaxID9606
Evidenceevidence at protein level
Length963
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesLRP8

GO terms

Show/Hide Table
GOName
GO:0001523 retinoid metabolic process
GO:0001540 amyloid-beta binding
GO:0004888 transmembrane signaling receptor activity
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006508 proteolysis
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0008035 high-density lipoprotein particle binding
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019894 kinesin binding
GO:0021517 ventral spinal cord development
GO:0021541 ammon gyrus development
GO:0021819 layer formation in cerebral cortex
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0030424 axon
GO:0030425 dendrite
GO:0032793 positive regulation of CREB transcription factor activity
GO:0034185 apolipoprotein binding
GO:0038024 cargo receptor activity
GO:0038025 reelin receptor activity
GO:0038026 reelin-mediated signaling pathway
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045088 regulation of innate immune response
GO:0047485 protein N-terminus binding
GO:0048306 calcium-dependent protein binding
GO:0048813 dendrite morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of chemical synaptic transmission
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0071363 cellular response to growth factor stimulus
GO:0071397 cellular response to cholesterol
GO:1900006 positive regulation of dendrite development

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
LRP8_HUMANAPOE_HUMANbhf-ucl, BioGRID, HPRD, IntAct12167620 12950167 32814053 8626535 details
LRP8_HUMANAMRP_HUMANBioGRID, DIP, HPRD, IntAct10231386 12899622 16101684 20223215 28514442 details
LRP8_HUMANAPC_HUMANDIP19116273 details
LRP8_HUMANNECA3_HUMANIntAct32814053 details
LRP8_HUMANCRCT1_HUMANIntAct32814053 details
LRP8_HUMANGGA1_HUMANIntAct32814053 details
LRP8_HUMANKAT5_HUMANIntAct32814053 details
LRP8_HUMANTHIO_HUMANIntAct32814053 details
LRP8_HUMANM3K5_HUMANIntAct32814053 details
LRP8_HUMANCTNB1_HUMANIntAct32814053 details
LRP8_HUMANKC1D_HUMANIntAct32814053 details
LRP8_HUMANAPLP2_HUMANIntAct32814053 details
LRP8_HUMANRELN_HUMANBioGRID, HPRD10571240 12167620 12670700 12899622 17548821 21844191 23951306 28446613 details
LRP8_HUMANGIPC1_HUMANBioGRID10827173 details
LRP8_HUMANJIP1_HUMANBioGRID10827173 10827199 details
LRP8_HUMANDLG4_HUMANBioGRID, HPRD10827173 16332682 details
LRP8_HUMANJIP2_HUMANBioGRID10827173 10827199 details
LRP8_HUMANSYJ2B_HUMANBioGRID10827173 details
LRP8_HUMANCAPON_HUMANBioGRID10827173 details
LRP8_HUMANSCN3A_HUMANBioGRID10827173 details
LRP8_HUMANAPBA2_HUMANBioGRID10827173 details
LRP8_HUMANDAB1_HUMANBioGRID, HPRD10380922 10827173 10827199 16481437 details
LRP8_HUMANITBP1_HUMANBioGRID10827173 details
LRP8_HUMANAPC10_HUMANBioGRID10827173 details
LRP8_HUMANSNX17_HUMANBioGRID, HPRD12169628 24705369 details
LRP8_HUMANMYLIP_HUMANBioGRID22109552 details
LRP8_HUMANMK_HUMANBioGRID12573468 details
LRP8_HUMANDAB2_HUMANBioGRID16101684 details
LRP8_HUMANVLDLR_HUMANBioGRID30873003 details
LRP8_HUMANLRP8_HUMANBioGRID30873003 details
LRP8_HUMANAPBA1_HUMANBioGRID17428983 details
LRP8_HUMANSSXT_HUMANIntAct20195357 details
LRP8_HUMANVGFR2_HUMANDIP30139844 details
LRP8_HUMANAPOH_HUMANBioGRID, HPRD12807892 details
LRP8_HUMANNMDZ1_HUMANBioGRID, HPRD16332682 details
LRP8_HUMANAPBB1_HUMANBioGRID17428983 details
LRP8_HUMANA4_HUMANBioGRID17428983 details
LRP8_HUMANCLUS_HUMANHPRD12824284 details