Entity Details

Primary name BECN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14457
EntryNameBECN1_HUMAN
FullNameBeclin-1
TaxID9606
Evidenceevidence at protein level
Length450
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesBECN1

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000407 phagophore assembly site
GO:0000422 autophagy of mitochondrion
GO:0000423 mitophagy
GO:0001666 response to hypoxia
GO:0005634 nucleus
GO:0005768 endosome
GO:0005776 autophagosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006968 cellular defense response
GO:0006995 cellular response to nitrogen starvation
GO:0007040 lysosome organization
GO:0007080 mitotic metaphase plate congression
GO:0007568 aging
GO:0008285 negative regulation of cell population proliferation
GO:0010008 endosome membrane
GO:0010040 response to iron(II) ion
GO:0010288 response to lead ion
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0016236 macroautophagy
GO:0016579 protein deubiquitination
GO:0019898 extrinsic component of membrane
GO:0019901 protein kinase binding
GO:0030425 dendrite
GO:0031625 ubiquitin protein ligase binding
GO:0031966 mitochondrial membrane
GO:0032465 regulation of cytokinesis
GO:0032801 receptor catabolic process
GO:0033197 response to vitamin E
GO:0034198 cellular response to amino acid starvation
GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II
GO:0035032 phosphatidylinositol 3-kinase complex, class III
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043652 engulfment of apoptotic cell
GO:0045022 early endosome to late endosome transport
GO:0045324 late endosome to vacuole transport
GO:0045335 phagocytic vesicle
GO:0048666 neuron development
GO:0050435 amyloid-beta metabolic process
GO:0050790 regulation of catalytic activity
GO:0051020 GTPase binding
GO:0051301 cell division
GO:0051607 defense response to virus
GO:0060548 negative regulation of cell death
GO:0070301 cellular response to hydrogen peroxide
GO:0071275 cellular response to aluminum ion
GO:0071280 cellular response to copper ion
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098780 response to mitochondrial depolarisation
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1902902 negative regulation of autophagosome assembly
GO:1905672 negative regulation of lysosome organization
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000786 positive regulation of autophagosome assembly
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Endosome
Endosome membrane
Golgi apparatus
Mitochondrion
Mitochondrion membrane
Nucleus

Domains

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DomainNameCategoryType
IPR007243 Atg6/BeclinFamilyFamily
IPR029318 Beclin-1, BH3 domainDomainDomain
IPR032913 Beclin-1FamilyFamily
IPR038274 Atg6/Beclin C-terminal domain superfamilyFamilyHomologous superfamily
IPR040455 Atg6, BARA domainDomainDomain
IPR041691 Atg6/beclin, coiled-coil domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00783 EstradiolDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule

Interactions

194 interactions

InteractorPartnerSourcesPublicationsLink
BECN1_HUMANBCL2_HUMANBioGRID, DIP, HPRD, IntAct, matrixdb, MINT16179260 17446862 18641390 19050071 19180116 19347031 19959994 20010695 20577262 20622903 20711182 20889974 21139567 21358617 21543763 21971985 22082873 22241963 22498477 22622204 23168911 23316280 23479509 23504944 23541952 23564079 23822101 23954414 24034250 24141421 24472739 24599950 24879154 25891078 25984893 27304906 28128446 28431397 28682313 29079782 29849149 29955058 31410188 31696776 32097085 32820146 9765397 details
BECN1_HUMANB2CL1_HUMANBioGRID, HPRD, MINT, UniProt17446862 18628207 18641390 19049976 19180116 19713971 20577262 22219388 22498477 24141421 24443581 9765397 details
BECN1_HUMANUVRAG_HUMANBioGRID, DIP, IntAct, MINT, UniProt18641390 18843052 19050071 19270693 19270696 19372752 20562859 21597469 22081109 22314358 22493499 23878393 23954414 24034250 24056303 24879154 24956373 25275521 25490155 25533187 26496610 27203177 27621469 29313410 29866835 30258449 30686098 31373534 32097085 32296183 details
BECN1_HUMANBECN1_HUMANBioGRID, IntAct18641390 19270696 20501938 20562859 22314358 24034250 24141421 24879154 27304906 27383850 28205554 29866835 details
BECN1_HUMANNRBF2_HUMANBioGRID, IntAct, UniProt20562859 24785657 24849286 25086043 26186194 26496610 28059666 28514442 details
BECN1_HUMANPK3C3_HUMANBioGRID, DIP, IntAct, matrixdb, UniProt16179260 16390869 18628207 18843052 19050071 19270693 19270696 19372752 19713971 20562859 20711182 21936852 23315026 23316280 23332761 23364696 23822101 23878393 23954414 23974797 24034250 24056303 24166503 24472739 24785657 24879154 24980959 24980960 25086043 25275521 25490155 25594178 25693418 25825496 25906440 26496610 26549445 26783301 27304906 27621469 28059666 28128446 28351972 28404643 28431397 28757208 28846113 29079782 29321306 29587298 29604308 30258449 30686098 30978004 31373534 31696776 31955515 33422265 details
BECN1_HUMANBAKOR_HUMANBioGRID, DIP, IntAct, MINT, UniProt18843052 19050071 19270693 19270696 19372752 20562859 20711182 21062745 22081109 22314358 22493499 23112296 23332761 23878393 23954414 24034250 24141421 24166503 24879154 24980960 25275521 25490155 25594178 25693418 25891078 26496610 26549445 27304906 27383850 27621469 28059666 28404643 28431397 28514442 28757208 29313410 29587298 29866835 30258449 31373534 31410188 31696776 32296183 details
BECN1_HUMANAMRA1_HUMANBioGRID, DIP, HPRD, IntAct, MINT17589504 20562859 20711182 20921139 21358617 23954414 23974797 24587252 25438055 25499913 30258449 details
BECN1_HUMANTAB2_HUMANBioGRID, MINT21976705 22081109 details
BECN1_HUMANSNX4_HUMANMINT22081109 details
BECN1_HUMANYES_HUMANBioGRID, IntAct25814554 details
BECN1_HUMANNXF1_HUMANBioGRID, IntAct32296183 details
BECN1_HUMANHSPB1_HUMANIntAct32814053 details
BECN1_HUMANIDLC_HUMANIntAct32814053 details
BECN1_HUMANBAG6_HUMANIntAct32814053 details
BECN1_HUMANMP2K3_HUMANBioGRID28205554 28628118 details
BECN1_HUMANERD22_HUMANBioGRID28205554 details
BECN1_HUMANCCND2_HUMANBioGRID28205554 details
BECN1_HUMANPI3R4_HUMANBioGRID, DIP, IntAct19050071 19270693 19270696 19372752 20562859 20711182 23878393 24166503 25490155 26496610 26549445 28059666 28351972 31696776 31955515 details
BECN1_HUMANFRS2_HUMANBioGRID, IntAct25814554 details
BECN1_HUMANSGF29_HUMANBioGRID, IntAct32296183 details
BECN1_HUMANHD_HUMANBioGRID, IntAct28445460 32814053 details
BECN1_HUMANTPH1_HUMANIntAct32814053 details
BECN1_HUMANWFS1_HUMANIntAct32814053 details
BECN1_HUMANTSC1_HUMANBioGRID, IntAct20562859 28205554 details
BECN1_HUMANTRAF6_HUMANBioGRID20501938 29326710 29929436 30258449 32384667 details
BECN1_HUMANHGFL_HUMANBioGRID24141421 details
BECN1_HUMANBRCA1_HUMANBioGRID, IntAct24378767 32814053 details
BECN1_HUMANPKN1_HUMANIntAct32814053 details
BECN1_HUMANKIF1B_HUMANIntAct32814053 details
BECN1_HUMANSMAD2_HUMANBioGRID28205554 details
BECN1_HUMANGFI1B_HUMANBioGRID, HPRD, IntAct16713569 details
BECN1_HUMANGRN_HUMANIntAct32814053 details
BECN1_HUMANGOPC_HUMANBioGRID, HPRD12372286 details
BECN1_HUMANUBC_HUMANBioGRID20501938 details
BECN1_HUMANARF_HUMANBioGRID19049976 28205554 details
BECN1_HUMANMP2K6_HUMANBioGRID28205554 details
BECN1_HUMANGAS7_HUMANMINT22081109 details
BECN1_HUMANQCR1_HUMANIntAct32814053 details
BECN1_HUMANCDN2B_HUMANBioGRID28205554 details
BECN1_HUMANTERT_HUMANBioGRID28205554 details
BECN1_HUMANDESP_HUMANMINT22081109 details
BECN1_HUMANWASH1_HUMANBioGRID, MINT23974797 24980959 details
BECN1_HUMANMAPK3_HUMANBioGRID25693418 details
BECN1_HUMANARAF_HUMANBioGRID28205554 details
BECN1_HUMANGSE1_HUMANMINT22081109 details
BECN1_HUMANFOS_HUMANIntAct32814053 details
BECN1_HUMANULK1_HUMANBioGRID21241894 25891078 27046250 27693506 28059666 28518135 29251248 29313410 29604308 30335599 details
BECN1_HUMANCDK6_HUMANBioGRID28205554 details
BECN1_HUMANEPHA2_HUMANBioGRID28205554 details
BECN1_HUMANITPR3_HUMANBioGRID22082873 details
BECN1_HUMANTAB3_HUMANBioGRID, MINT21976705 22081109 details
BECN1_HUMANCASP3_HUMANBioGRID19713971 details
BECN1_HUMANTRAF2_HUMANBioGRID28521610 details
BECN1_HUMANRACK1_HUMANBioGRID24166503 26549445 details
BECN1_HUMANPRPS1_HUMANIntAct32814053 details
BECN1_HUMANKLF11_HUMANIntAct32814053 details
BECN1_HUMANDNJB6_HUMANIntAct32814053 details
BECN1_HUMANERBB2_HUMANBioGRID23703612 28205554 28351972 details
BECN1_HUMANMERL_HUMANBioGRID28205554 details
BECN1_HUMANARNT_HUMANBioGRID28205554 details
BECN1_HUMANMDM4_HUMANBioGRID28205554 details
BECN1_HUMANZWINT_HUMANBioGRID, IntAct, MINT20562859 22081109 23478334 details
BECN1_HUMANATX3_HUMANBioGRID, IntAct28445460 details
BECN1_HUMANTBB2A_HUMANIntAct32814053 details
BECN1_HUMANPIAS4_HUMANIntAct32814053 details
BECN1_HUMANITCH_HUMANBioGRID21936852 details
BECN1_HUMANCDN2A_HUMANBioGRID19049976 28205554 details
BECN1_HUMANRAF1_HUMANBioGRID28205554 details
BECN1_HUMANAKT1_HUMANBioGRID, DIP23112296 28205554 29669822 details
BECN1_HUMANTNC18_HUMANMINT22081109 details
BECN1_HUMANMAPK2_HUMANBioGRID25693418 details
BECN1_HUMANGRM1_HUMANBioGRID28205554 details
BECN1_HUMANBTK_HUMANBioGRID, IntAct25814554 details
BECN1_HUMANGRB2_HUMANIntAct32814053 details
BECN1_HUMANLSAMP_HUMANIntAct32814053 details
BECN1_HUMANTCPE_HUMANIntAct32814053 details
BECN1_HUMANB2L10_HUMANBioGRID22498477 details
BECN1_HUMANHERC5_HUMANBioGRID25906440 32093773 details
BECN1_HUMANTEAD2_HUMANBioGRID28205554 details
BECN1_HUMANDAPK1_HUMANBioGRID, MINT19180116 details
BECN1_HUMANTRI40_HUMANMINT22081109 details
BECN1_HUMANGRIA1_HUMANIntAct32814053 details
BECN1_HUMANATX1_HUMANIntAct32814053 details
BECN1_HUMANLATS2_HUMANBioGRID28205554 details
BECN1_HUMANFZR1_HUMANBioGRID28205554 details
BECN1_HUMANPGK1_HUMANBioGRID28238651 details
BECN1_HUMANFGFR4_HUMANBioGRID28205554 details
BECN1_HUMANSTK11_HUMANBioGRID28205554 details
BECN1_HUMANCOQA1_HUMANIntAct32814053 details
BECN1_HUMANNEDD4_HUMANBioGRID21936852 28128446 29251248 details
BECN1_HUMANPGFRA_HUMANBioGRID28205554 details
BECN1_HUMANMP2K5_HUMANBioGRID28205554 details
BECN1_HUMANITPR1_HUMANBioGRID22082873 details
BECN1_HUMANPLEC_HUMANMINT22081109 details
BECN1_HUMANSRC_HUMANIntAct32814053 details
BECN1_HUMANTYRO_HUMANIntAct32814053 details
BECN1_HUMANPFD3_HUMANIntAct32814053 details
BECN1_HUMANRNF11_HUMANIntAct32814053 details
BECN1_HUMANATG3_HUMANBioGRID24186333 details
BECN1_HUMANKAT2A_HUMANBioGRID28205554 details
BECN1_HUMANGLIS2_HUMANBioGRID28205554 details
BECN1_HUMANING4_HUMANMINT22081109 details
BECN1_HUMANSHD_HUMANBioGRID, IntAct25814554 details
BECN1_HUMANFLNA_HUMANIntAct32814053 details
BECN1_HUMANRAC1_HUMANIntAct32814053 details
BECN1_HUMANRARA_HUMANIntAct32814053 details
BECN1_HUMANEZRI_HUMANIntAct32814053 details
BECN1_HUMANSENP3_HUMANBioGRID31373534 details
BECN1_HUMANSTYK1_HUMANBioGRID31696776 details
BECN1_HUMANGATM_HUMANIntAct32814053 details
BECN1_HUMANRSMB_HUMANIntAct32814053 details
BECN1_HUMANCDK4_HUMANBioGRID28205554 details
BECN1_HUMANQCR7_HUMANIntAct32814053 details
BECN1_HUMANHS90A_HUMANBioGRID21543763 details
BECN1_HUMANXPO1_HUMANBioGRID, HPRD11309306 26673895 details
BECN1_HUMANP53_HUMANBioGRID28128446 details
BECN1_HUMANTRI16_HUMANBioGRID27693506 details
BECN1_HUMANBIP_HUMANBioGRID29669822 details
BECN1_HUMANUBP19_HUMANBioGRID32453962 details
BECN1_HUMANRUBIC_HUMANBioGRID, IntAct, UniProt19270693 19270696 19372752 20562859 21062745 22493499 23954414 24034250 24980960 25594178 25891078 26496610 26876213 27621469 29587298 31373534 31696776 details
BECN1_HUMANUBP14_HUMANBioGRID29326710 31272261 details
BECN1_HUMANEXOC8_HUMANBioGRID, IntAct21241894 26387716 details
BECN1_HUMANDDB1_HUMANBioGRID, MINT23974797 25499913 details
BECN1_HUMANK1C18_HUMANDIP23112296 details
BECN1_HUMANDYL1_HUMANBioGRID20921139 details
BECN1_HUMANMTOR_HUMANBioGRID25533187 details
BECN1_HUMANIL24_HUMANBioGRID20406981 details
BECN1_HUMANUBP7_HUMANBioGRID31955515 details
BECN1_HUMANKCC2G_HUMANBioGRID29079782 details
BECN1_HUMANHYPK_HUMANBioGRID27067261 details
BECN1_HUMANSTK38_HUMANBioGRID26387716 details
BECN1_HUMANVIME_HUMANBioGRID, DIP23112296 31272261 details
BECN1_HUMANTNAP3_HUMANBioGRID20501938 details
BECN1_HUMANUBP18_HUMANBioGRID25906440 details
BECN1_HUMANATGA1_HUMANBioGRID30081750 details
BECN1_HUMANNHLC1_HUMANBioGRID31758957 details
BECN1_HUMANMCL1_HUMANBioGRID, MINT21139567 22219388 details
BECN1_HUMANGAPR1_HUMANDIP23364696 details
BECN1_HUMANTNIK_HUMANIntAct31413325 details
BECN1_HUMANHS71B_HUMANBioGRID23569248 details
BECN1_HUMANBAD_HUMANBioGRID28518135 details
BECN1_HUMANDC1I1_HUMANBioGRID20921139 details
BECN1_HUMANCASP8_HUMANBioGRID29669822 details
BECN1_HUMANDIRA3_HUMANBioGRID24879154 details
BECN1_HUMANANDR_HUMANBioGRID, IntAct28445460 details
BECN1_HUMANDISC1_HUMANIntAct31413325 details
BECN1_HUMANEXOC2_HUMANBioGRID21241894 24056301 details
BECN1_HUMANPRKN_HUMANBioGRID24386307 24879156 29330382 details
BECN1_HUMANTRI13_HUMANBioGRID31375263 details
BECN1_HUMANBIRC5_HUMANBioGRID, MINT20638385 26148234 details
BECN1_HUMANRO52_HUMANBioGRID26347139 details
BECN1_HUMANTF65_HUMANBioGRID28128446 details
BECN1_HUMANPIAS3_HUMANBioGRID31373534 details
BECN1_HUMANRN216_HUMANBioGRID25484083 29361549 details
BECN1_HUMANPSD10_HUMANBioGRID25905985 details
BECN1_HUMANEPM2A_HUMANBioGRID31758957 details
BECN1_HUMANRALB_HUMANIntAct21241894 details
BECN1_HUMANEGFR_HUMANIntAct24034250 details
BECN1_HUMANATN1_HUMANBioGRID, IntAct28445460 details
BECN1_HUMANDACT1_HUMANBioGRID24980960 details
BECN1_HUMANRD23A_HUMANBioGRID27613096 details
BECN1_HUMANLPPRC_HUMANBioGRID23822101 details
BECN1_HUMANEXOC4_HUMANBioGRID, IntAct21241894 details
BECN1_HUMANHMGB1_HUMANBioGRID, UniProt20819940 29361549 details
BECN1_HUMANRB39A_HUMANUniProt24349490 details
BECN1_HUMANHAX1_HUMANBioGRID20467442 details
BECN1_HUMANRB39B_HUMANUniProt24349490 details
BECN1_HUMANIRGM_HUMANBioGRID25891078 details
BECN1_HUMANNEK2_HUMANBioGRID31955515 details
BECN1_HUMANCYLD_HUMANBioGRID32453962 details
BECN1_HUMANJOS1_HUMANBioGRID32453962 details
BECN1_HUMANVMP1_HUMANUniProt23316280 details
BECN1_HUMANSPHK1_HUMANBioGRID28521610 details
BECN1_HUMANRBCC1_HUMANBioGRID28059666 details
BECN1_HUMANWDR81_HUMANBioGRID, UniProt26783301 28404643 details
BECN1_HUMANATG13_HUMANBioGRID27046250 29313410 details
BECN1_HUMANEFTU_HUMANBioGRID26876213 details
BECN1_HUMANTRI50_HUMANBioGRID29604308 details
BECN1_HUMANCXA1_HUMANBioGRID24705551 details
BECN1_HUMANAAPK1_HUMANBioGRID27304906 details
BECN1_HUMANWDR91_HUMANBioGRID, UniProt26783301 28404643 details
BECN1_HUMANHS71A_HUMANBioGRID23569248 details
BECN1_HUMANMEFV_HUMANBioGRID26347139 details
BECN1_HUMANS10A8_HUMANBioGRID21971985 details
BECN1_HUMANRING2_HUMANBioGRID24980959 details
BECN1_HUMANBIN1_HUMANBioGRID31211444 details
BECN1_HUMANUBP33_HUMANBioGRID24056301 details
BECN1_HUMANTOP2B_HUMANBioGRID28345663 details
BECN1_HUMANTRIM3_HUMANBioGRID32021240 details
BECN1_HUMANOTU7B_HUMANBioGRID32453962 details
BECN1_HUMANCAF1A_HUMANBioGRID18843052 details
BECN1_HUMANCSN3_HUMANBioGRID29970115 details
BECN1_HUMANSQSTM_HUMANBioGRID29669822 32384667 details