Entity Details

Primary name HLA-DRB1
Entity type gene
Source Source Link

Details

PrimaryID3123
RefseqGeneNG_029921
SymbolHLA-DRB1
Namemajor histocompatibility complex, class II, DR beta 1
Chromosome6
Location6p21.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsDRB1_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001772 immunological synapse
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001934 positive regulation of protein phosphorylation
GO:0002437 inflammatory response to antigenic stimulus
GO:0002469 myeloid dendritic cell antigen processing and presentation
GO:0002491 antigen processing and presentation of endogenous peptide antigen via MHC class II
GO:0002503 peptide antigen assembly with MHC class II protein complex
GO:0002842 positive regulation of T cell mediated immune response to tumor cell
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005200 structural constituent of cytoskeleton
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0008544 epidermis development
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016045 detection of bacterium
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 MHC class II protein complex binding
GO:0030225 macrophage differentiation
GO:0030247 polysaccharide binding
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0032395 MHC class II receptor activity
GO:0032588 trans-Golgi network membrane
GO:0032653 regulation of interleukin-10 production
GO:0032673 regulation of interleukin-4 production
GO:0032689 negative regulation of interferon-gamma production
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0033674 positive regulation of kinase activity
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042088 T-helper 1 type immune response
GO:0042130 negative regulation of T cell proliferation
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042613 MHC class II protein complex
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043382 positive regulation of memory T cell differentiation
GO:0043410 positive regulation of MAPK cascade
GO:0045622 regulation of T-helper cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046598 positive regulation of viral entry into host cell
GO:0050852 T cell receptor signaling pathway
GO:0051262 protein tetramerization
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
HLA-DRB1HLA-DRABioGRID, HPRD, InnateDB, IntAct, MINT11432818 11877480 21131964 26186194 28514442 7477400 9354468 details
HLA-DRB1HSPA1AIntAct17357109 24428437 details
HLA-DRB1HSPA1BIntAct17357109 24428437 details
HLA-DRB1TRIM21BioGRID18022694 details
HLA-DRB1MAGEA3BioGRID12393675 details
HLA-DRB1MARCHF1BioGRID23264739 details
HLA-DRB1ZDHHC17BioGRID24705354 details
HLA-DRB1DISC1IntAct31413325 details
HLA-DRB1VCPBioGRID18022694 details
HLA-DRB1CTAG1BHPRD11782380 details
HLA-DRB1CD9MINT23289620 details
HLA-DRB1MMEMINT23289620 details
HLA-DRB1MPPE1IntAct28514442 details
HLA-DRB1TCTN2IntAct28514442 details
HLA-DRB1BTN2A2BioGRID, IntAct28514442 details
HLA-DRB1EIF2AK3BioGRID, IntAct28514442 details
HLA-DRB1BPNT2BioGRID, IntAct28514442 details
HLA-DRB1CNNM1BioGRID, IntAct28514442 details
HLA-DRB1EMC6BioGRID, IntAct28514442 details
HLA-DRB1RNF149BioGRID, IntAct28514442 details
HLA-DRB1KIAA0319LBioGRID, IntAct28514442 details
HLA-DRB1HLA-DRB5BioGRID, IntAct26186194 28514442 details
HLA-DRB1SQLEBioGRID, IntAct28514442 details
HLA-DRB1PDE3BBioGRID, IntAct28514442 details
HLA-DRB1ITGA6BioGRID, IntAct28514442 details
HLA-DRB1HLA-DRB1BioGRID, IntAct26186194 28514442 details
HLA-DRB1SEMA4FBioGRID, IntAct28514442 details
HLA-DRB1CTDNEP1BioGRID, IntAct28514442 details
HLA-DRB1HLA-DRB3BioGRID, IntAct26186194 28514442 details
HLA-DRB1PKMBioGRID20458337 details
HLA-DRB1HSP90AA1BioGRID20458337 details
HLA-DRB1HSPA8BioGRID20458337 details
HLA-DRB1ANXA11BioGRID20458337 details
HLA-DRB1HSP90AB1BioGRID20458337 details
HLA-DRB1ATP1B1BioGRID20458337 details
HLA-DRB1YWHAEBioGRID20458337 details
HLA-DRB1MS4A1BioGRID20458337 details
HLA-DRB1PHOSPHO1BioGRID26186194 details
HLA-DRB1OGNBioGRID26186194 details
HLA-DRB1NAALADL2BioGRID26186194 details
HLA-DRB1FNDC4BioGRID26186194 details
HLA-DRB1CNDP1BioGRID26186194 details