Entity Details

Primary name JAK2
Entity type gene
Source Source Link

Details

PrimaryID3717
RefseqGeneNG_009904
SymbolJAK2
NameJanus kinase 2
Chromosome9
Location9p24.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1995-01-09
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsJAK2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000791 euchromatin
GO:0001774 microglial cell activation
GO:0002250 adaptive immune response
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007498 mesoderm development
GO:0007596 blood coagulation
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030041 actin filament polymerization
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031103 axon regeneration
GO:0031702 type 1 angiotensin receptor binding
GO:0031904 endosome lumen
GO:0031959 mineralocorticoid receptor signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032496 response to lipopolysaccharide
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033130 acetylcholine receptor binding
GO:0033194 response to hydroperoxide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0035409 histone H3-Y41 phosphorylation
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042169 SH2 domain binding
GO:0042307 positive regulation of protein import into nucleus
GO:0042393 histone binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042976 activation of Janus kinase activity
GO:0042981 regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0045121 membrane raft
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046677 response to antibiotic
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of chemical synaptic transmission
GO:0050867 positive regulation of cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051428 peptide hormone receptor binding
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0060399 positive regulation of growth hormone receptor signaling pathway
GO:0061180 mammary gland epithelium development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070671 response to interleukin-12
GO:0070757 interleukin-35-mediated signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:2000273 positive regulation of signaling receptor activity

Diseases

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Interactions

139 interactions

InteractorPartnerSourcesPublicationsLink
JAK2EGFRBioGRID, HPRD, MINT10358079 10635327 16273093 23838182 24240702 9363897 details
JAK2ERBB3BioGRID, MINT16273093 details
JAK2GRB2BioGRID, HPRD, IntAct17474147 7500025 8536716 8950973 details
JAK2NCK1IntAct17474147 details
JAK2PIK3R1BioGRID, HPRD, IntAct10026141 16135792 17474147 8702385 details
JAK2PLCG1BioGRID, IntAct14978237 17474147 details
JAK2CSF2RBBioGRID, HPRD, IntAct, MINT10772872 16437163 18692472 21965659 7527392 7775438 details
JAK2PTPN1BioGRID, HPRD, MINT11694501 11970898 15821101 21806020 details
JAK2PTPRJIntAct19167335 details
JAK2SOCS3BioGRID, HPRD, MINT10421843 10882725 11314018 14517242 15514089 19543316 22342841 24354892 24438103 29752723 9344848 details
JAK2SOCS1BioGRID, HPRD, MINT10064597 10421843 10455112 11314018 11713228 11971965 14517242 14522994 18508766 19287004 28258213 29674694 29991678 9202126 9344848 details
JAK2SH2B1BioGRID, HPRD, MINT10757801 12370803 12551917 15316008 15767667 17565041 9343427 details
JAK2SH2B2BioGRID, HPRD, MINT10374881 10872802 15767667 details
JAK2PRMT5BioGRID, HPRD, IntAct10531356 21316606 details
JAK2ASS1BioGRID, IntAct21988832 details
JAK2RBMXBioGRID, IntAct21988832 details
JAK2TRAF6BioGRID, IntAct21988832 details
JAK2PPP1CCBioGRID, IntAct21382349 details
JAK2CDKN1BBioGRID, I2D21423214 details
JAK2STAT1BioGRID, HPRD, MINT10918587 11152457 11294897 11839738 12637327 12817007 14978237 15284024 15322115 19834108 20353823 24255956 7543024 7657660 7690989 details
JAK2JAK1BioGRID, IntAct26175413 32001089 details
JAK2IL5RABioGRID, HPRD, IntAct9516124 details
JAK2JAK2BioGRID, DIP, HPRD10026141 11593427 11818507 15121872 15143187 15143188 15767667 16609991 17027227 21841788 22820988 24354892 7889566 8041779 8609418 9111318 9516124 details
JAK2STAT3BioGRID, HPRD, IntAct10918587 10925297 11294897 11350938 11940572 12244095 12576423 12626508 14551213 15156153 15284024 19834108 23838182 26775640 27351213 30413785 8626374 9211920 details
JAK2IL12RB2BioGRID, HPRD10198225 details
JAK2EPORBioGRID, HPRD11779507 12441334 14982882 8343951 details
JAK2FYNBioGRID, HPRD10551884 details
JAK2STAT5ABioGRID, HPRD11413148 7925280 8617237 9047382 9575217 details
JAK2STAT5BBioGRID, HPRD12538627 24354892 9047382 9575217 details
JAK2DNAJA3BioGRID, HPRD11679576 details
JAK2TECBioGRID, HPRD9178903 9473212 details
JAK2VAV1BioGRID, HPRD7530656 9162069 details
JAK2IRS1BioGRID, HPRD11208867 12960006 15316008 9492017 details
JAK2PTPN11BioGRID, HPRD7559603 8639815 8912646 8995399 9442080 details
JAK2TNFRSF1ABioGRID, HPRD18606683 9510175 details
JAK2LYNBioGRID, HPRD9573010 details
JAK2RAF1BioGRID, HPRD10205168 11134016 8876196 9689060 details
JAK2IFNGR2BioGRID, HPRD7514165 7673114 details
JAK2SHC1BioGRID, HPRD7535773 9126968 details
JAK2TUBBioGRID, HPRD10455176 details
JAK2STAMBioGRID, HPRD9133424 details
JAK2IKBKGBioGRID20098747 details
JAK2GTF2IBioGRID, HPRD11313464 11373296 11934902 9012831 9837922 details
JAK2H3-4BioGRID19783980 details
JAK2MAP3K5BioGRID19287004 details
JAK2EZH2BioGRID24469040 details
JAK2ARL11BioGRID27229929 details
JAK2HSFY1BioGRID27229929 details
JAK2CBLBioGRID28676638 details
JAK2BRCA1BioGRID, HPRD, MINT11163768 details
JAK2LEPRHPRD, IntAct11585385 8608603 details
JAK2G3BP1MINT15743820 details
JAK2MPLBioGRID, HPRD, IntAct10224114 10918061 10979953 24931576 30755420 7534285 details
JAK2TYK2IntAct26175413 details
JAK2ROCK2IntAct30413785 details
JAK2STRA6IntAct21368206 details
JAK2PPIABioGRID, HPRD12668872 details
JAK2CXCR4BioGRID, HPRD10506573 details
JAK2HSPA8BioGRID, HPRD11679576 details
JAK2PTPN12BioGRID, HPRD11731619 details
JAK2PTK2BioGRID10925297 9553131 details
JAK2GHRBioGRID, HPRD10502458 21347402 24280222 7540178 8063815 details
JAK2SIRPABioGRID, HPRD10842184 details
JAK2PTK2BBioGRID, HPRD11818507 details
JAK2PTPN6BioGRID, HPRD10772872 8943354 details
JAK2HTR2ABioGRID, HPRD9169451 details
JAK2ERBB2BioGRID, HPRD11940572 details
JAK2ELP2BioGRID, HPRD10954736 details
JAK2KITBioGRID, HPRD7527392 8611693 9355737 details
JAK2PPP2R1BBioGRID, HPRD11440634 details
JAK2IFNGR1BioGRID, HPRD11438544 21689637 7499845 7673114 details
JAK2CCR5BioGRID, HPRD11278738 11591716 details
JAK2PRLRBioGRID, HPRD10772872 20962278 9202403 details
JAK2IL6STBioGRID9388212 details
JAK2GRB10BioGRID, HPRD9632636 details
JAK2TSHRBioGRID, HPRD10809230 details
JAK2INSRBioGRID, HPRD12456798 8912646 details
JAK2STAM2BioGRID, HPRD10899310 details
JAK2IL2RBBioGRID9553136 details
JAK2CTLA4BioGRID, HPRD10842319 details
JAK2ALKBioGRID14968112 details
JAK2FGFR1BioGRID20388777 details
JAK2HSP90AA1BioGRID20353823 details
JAK2HSP90AB1BioGRID20353823 details
JAK2ASB2BioGRID21119685 details
JAK2SKP2BioGRID21119685 details
JAK2H3C14BioGRID21689637 details
JAK2VHLBioGRID21685897 32356150 details
JAK2AGTR1BioGRID, HPRD11152457 7746328 details
JAK2PTAFRBioGRID14500680 details
JAK2IL4RBioGRID, HPRD8609418 details
JAK2IL2RGBioGRID8041779 details
JAK2CALM1BioGRID12626508 details
JAK2JAK3BioGRID, HPRD11585385 12207328 details
JAK2HES1BioGRID, HPRD15156153 details
JAK2HES5BioGRID, HPRD15156153 details
JAK2DTX3LBioGRID24886089 details
JAK2HDAC6BioGRID26775640 details
JAK2GOLPH3BioGRID29713848 details
JAK2IGF1RBioGRID, HPRD10747872 15044591 9492017 details
JAK2PARP9BioGRID23487038 details
JAK2LNX1BioGRID30634502 details
JAK2LDOC1BioGRID30634502 details
JAK2PKD1HPRD12007403 details
JAK2STAT2HPRD7746328 details
JAK2FESHPRD8631962 details
JAK2CRLF2HPRD10872831 details
JAK2PLCG2HPRD14978237 details
JAK2IRS2HPRD12960006 details
JAK2NFKBIAHPRD11493922 details
JAK2PDGFRBHPRD8657151 9484840 details
JAK2IL3RAHPRD15988755 details
JAK2MST1RHPRD14982882 details
JAK2PPP2CAHPRD11440634 details
JAK2CSF3RHPRD7775438 details
JAK2BCRHPRD12023981 12370803 details
JAK2PTPRCHPRD11201744 details
JAK2MDKHPRD9452495 details
JAK2YES1HPRD8702385 details
JAK2ABL1HPRD11593427 15143187 9111318 details
JAK2VCPHPRD11087817 details
JAK2CCR2HPRD9670957 details
JAK2PPP2R5AHPRD8702385 details
JAK2OSMRHPRD10586060 details
JAK2STAP2HPRD12540842 details
JAK2IL23RHPRD12023369 details
JAK2UBASH3BHPRD12370296 details
JAK2SRCBioGRID, IntAct21075308 details
JAK2PKMIntAct24606918 details
JAK2UBP1BioGRID, IntAct25852190 details
JAK2SLC2A1BioGRID, IntAct25852190 details
JAK2NAP1L1BioGRID, IntAct25852190 details
JAK2EMDBioGRID, IntAct25852190 details
JAK2RCN1BioGRID, IntAct25852190 details
JAK2KPNB1BioGRID, IntAct25852190 details
JAK2RNF123BioGRID29676528 details
JAK2CUL4ABioGRID30945288 details
JAK2CUL4BBioGRID30945288 details
JAK2HNRNPLBioGRID28611215 details