Entity Details

Primary name HERC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15751
EntryNameHERC1_HUMAN
FullNameProbable E3 ubiquitin-protein ligase HERC1
TaxID9606
Evidenceevidence at protein level
Length4861
SequenceStatuscomplete
DateCreated2008-04-08
DateModified2021-06-02

Ontological Relatives

GenesHERC1

GO terms

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GOName
GO:0004842 ubiquitin-protein transferase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0010507 negative regulation of autophagy
GO:0016020 membrane
GO:0021702 cerebellar Purkinje cell differentiation
GO:0031175 neuron projection development
GO:0050885 neuromuscular process controlling balance

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus
Membrane

Domains

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DomainNameCategoryType
IPR000408 Regulator of chromosome condensation, RCC1RepeatRepeat
IPR000569 HECT domainDomainDomain
IPR001680 WD40 repeatRepeatRepeat
IPR001870 B30.2/SPRY domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein IIFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR035768 HERC1, SPRY domainDomainDomain
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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