Entity Details

Primary name UBP27_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA6NNY8
EntryNameUBP27_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase 27
TaxID9606
Evidenceevidence at transcript level
Length438
SequenceStatuscomplete
DateCreated2007-10-02
DateModified2021-06-02

Ontological Relatives

GenesUSP27X

GO terms

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GOName
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:0043065 positive regulation of apoptotic process
GO:0050821 protein stabilization
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:1990380 Lys48-specific deubiquitinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300984 OMIMMental retardation, X-linked 105 (MRX105)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions