Entity Details

Primary name MMP3
Entity type gene
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Details

PrimaryID4314
RefseqGeneNG_012100
SymbolMMP3
Namematrix metallopeptidase 3
Chromosome11
Location11q22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-03-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMMP3_HUMAN

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0010727 negative regulation of hydrogen peroxide metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0031334 positive regulation of protein-containing complex assembly
GO:0071492 cellular response to UV-A
GO:0071732 cellular response to nitric oxide
GO:0150077 regulation of neuroinflammatory response
GO:1903209 positive regulation of oxidative stress-induced cell death
GO:1904645 response to amyloid-beta

Diseases

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Disease IDSourceNameDescription
614466 OMIMCoronary heart disease 6 (CHDS6)A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Disease susceptibility is associated with variants affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.