Entity Details

Primary name KCNJ8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15842
EntryNameKCNJ8_HUMAN
FullNameATP-sensitive inward rectifier potassium channel 8
TaxID9606
Evidenceevidence at protein level
Length424
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesKCNJ8

GO terms

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GOName
GO:0001822 kidney development
GO:0005242 inward rectifier potassium channel activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0006813 potassium ion transport
GO:0007507 heart development
GO:0008076 voltage-gated potassium channel complex
GO:0008282 inward rectifying potassium channel
GO:0015272 ATP-activated inward rectifier potassium channel activity
GO:0017098 sulfonylurea receptor binding
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0030016 myofibril
GO:0031004 potassium ion-transporting ATPase complex
GO:0032496 response to lipopolysaccharide
GO:0034765 regulation of ion transmembrane transport
GO:0042383 sarcolemma
GO:0043330 response to exogenous dsRNA
GO:0051607 defense response to virus
GO:0071805 potassium ion transmembrane transport
GO:0098662 inorganic cation transmembrane transport
GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential
GO:0150104 transport across blood-brain barrier
GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003278 Potassium channel, inwardly rectifying, Kir6.1FamilyFamily
IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmicFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR016449 Potassium channel, inwardly rectifying, KirFamilyFamily
IPR040445 Potassium channel, inwardly rectifying, transmembrane domainDomainDomain
IPR041647 Inward rectifier potassium channel, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00914 PhenforminDrugbanksmall molecule
DB00922 LevosimendanDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01154 ThiamylalDrugbanksmall molecule
DB01251 GliquidoneDrugbanksmall molecule
DB01289 GlisoxepideDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule