Entity Details

Primary name NFE2L2
Entity type gene
Source Source Link

Details

PrimaryID4780
RefseqGene
SymbolNFE2L2
Namenuclear factor, erythroid 2 like 2
Chromosome2
Location2q31.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-21
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsNF2L2_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 transcription coregulator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006954 inflammatory response
GO:0007568 aging
GO:0010226 response to lithium ion
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010628 positive regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010976 positive regulation of neuron projection development
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0019904 protein domain specific binding
GO:0030194 positive regulation of blood coagulation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032993 protein-DNA complex
GO:0034599 cellular response to oxidative stress
GO:0035690 cellular response to drug
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043565 sequence-specific DNA binding
GO:0045454 cell redox homeostasis
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045995 regulation of embryonic development
GO:0046223 aflatoxin catabolic process
GO:0046326 positive regulation of glucose import
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070301 cellular response to hydrogen peroxide
GO:0071280 cellular response to copper ion
GO:0071356 cellular response to tumor necrosis factor
GO:0071498 cellular response to fluid shear stress
GO:0071499 cellular response to laminar fluid shear stress
GO:1902037 negative regulation of hematopoietic stem cell differentiation
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903788 positive regulation of glutathione biosynthetic process
GO:1904385 cellular response to angiotensin
GO:1904753 negative regulation of vascular associated smooth muscle cell migration
GO:2000121 regulation of removal of superoxide radicals
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process

Diseases

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Interactions

139 interactions

InteractorPartnerSourcesPublicationsLink
NFE2L2KEAP1BioGRID, DIP, HPRD, IntAct, MINT, UniProt11439354 11909699 12145307 14517290 14585973 15475350 15572695 15601839 15985429 16006525 16449638 16790436 16888629 17015834 17462537 17822677 18387606 18417180 18757741 18981988 19706542 20027226 20421418 20463144 20484052 20486933 20599909 21262351 21383067 21988832 22215675 22245129 22302998 22331464 22558124 23066931 23382044 23645672 23722832 23727018 23857982 23986495 24011591 24130096 24322982 24512214 24704364 24844779 25582950 25628777 26078718 26536456 27091842 27212020 27621311 28186440 28416489 28533375 28534518 28617433 28638054 28939422 29033244 29255090 29423025 29792731 30122040 30126895 30383469 30465941 30473361 30576774 30692632 30765703 30778200 30793592 31169361 31257023 31262713 31541481 31695040 31891690 32057361 32159343 32206121 32605589 32854194 32911434 9887101 details
NFE2L2RBMXBioGRID, IntAct21988832 details
NFE2L2STAT3IntAct32911434 details
NFE2L2COPS7ABioGRID, HPRD, IntAct12020345 32911434 details
NFE2L2UBE2E2BioGRID20484052 details
NFE2L2MAFGBioGRID, HPRD, IntAct, MINT, UniProt11013233 18692475 21988832 22942279 23661758 23737527 24140708 25416956 32296183 32911434 9150357 details
NFE2L2KDM1ABioGRID, IntAct32296183 details
NFE2L2ATF3IntAct32911434 details
NFE2L2ETS2IntAct32911434 details
NFE2L2RELIntAct32911434 details
NFE2L2ELF3IntAct32911434 details
NFE2L2MAPK8BioGRID24704364 31945188 details
NFE2L2KPNA3BioGRID, IntAct21988832 details
NFE2L2MAFKBioGRID, HPRD, IntAct10747902 11013233 21988832 23737527 32296183 32911434 9150357 details
NFE2L2TNNT1BioGRID, IntAct25416956 31515488 32296183 details
NFE2L2MAFFBioGRID, HPRD, IntAct, UniProt12490281 23661758 23737527 26186194 28514442 32911434 details
NFE2L2ELK1IntAct32911434 details
NFE2L2TBPIntAct32911434 details
NFE2L2DCAF11BioGRID28453520 details
NFE2L2FOSL2IntAct32911434 details
NFE2L2ZBTB24IntAct32911434 details
NFE2L2PMF1BioGRID, HPRD, IntAct10419538 11256947 12020345 32911434 details
NFE2L2UBE2E3BioGRID20484052 details
NFE2L2PAQR4BioGRID32206121 details
NFE2L2BRPF3IntAct32911434 details
NFE2L2KPNA2IntAct32911434 details
NFE2L2ENC1BioGRID17875699 18981988 20511222 details
NFE2L2CASP7IntAct32911434 details
NFE2L2GSK3BBioGRID22751928 details
NFE2L2SP140IntAct32911434 details
NFE2L2FOSBIntAct32911434 details
NFE2L2LEF1IntAct32911434 details
NFE2L2JUNBioGRID, HPRD, IntAct12805554 20194533 20232342 32911434 9872330 details
NFE2L2NFE2BioGRID, HPRD, UniProt12805554 23661758 details
NFE2L2TRIM24BioGRID, IntAct20211142 details
NFE2L2CREBBPBioGRID, HPRD11683914 18241676 19273602 details
NFE2L2WACBioGRID, IntAct25416956 31515488 details
NFE2L2CASP3HPRD10510468 details
NFE2L2ATF4BioGRID, HPRD, IntAct, UniProt11274184 23661758 26700459 32911434 details
NFE2L2SMAD1IntAct32911434 details
NFE2L2ARPC2IntAct32911434 details
NFE2L2CASP1BioGRID, HPRD10510468 28247911 details
NFE2L2ATMIntAct32911434 details
NFE2L2MAP2K6IntAct32911434 details
NFE2L2DDIT3IntAct32911434 details
NFE2L2EIF2AK3BioGRID, HPRD14517290 details
NFE2L2CDH1BioGRID22302998 details
NFE2L2CEBPGIntAct32911434 details
NFE2L2ARFIP2IntAct32911434 details
NFE2L2CFAP299IntAct32911434 details
NFE2L2TADA2AIntAct32911434 details
NFE2L2HNRNPRIntAct32911434 details
NFE2L2BRPF1IntAct32911434 details
NFE2L2SPICIntAct32911434 details
NFE2L2ELF4IntAct32911434 details
NFE2L2ZNF396IntAct32911434 details
NFE2L2RELAIntAct32911434 details
NFE2L2CREB3BioGRID, UniProt23661758 details
NFE2L2NFE2L3BioGRID, UniProt23661758 details
NFE2L2MAPK7BioGRID23043106 details
NFE2L2PRKCABioGRID12947090 details
NFE2L2EIF3JIntAct32911434 details
NFE2L2ELF5IntAct32911434 details
NFE2L2IRF2IntAct32911434 details
NFE2L2CERS2IntAct32911434 details
NFE2L2TEFIntAct32911434 details
NFE2L2BPTFBioGRID15379550 details
NFE2L2GRB2IntAct32911434 details
NFE2L2CREBL2IntAct32911434 details
NFE2L2CREBZFIntAct32911434 details
NFE2L2NFAT5IntAct32911434 details
NFE2L2ETV6IntAct32911434 details
NFE2L2ETV1IntAct32911434 details
NFE2L2NCOR2BioGRID15870285 details
NFE2L2SUMO1BioGRID23543742 details
NFE2L2SUMO2BioGRID23543742 details
NFE2L2IRF1IntAct32911434 details
NFE2L2KPNA4IntAct32911434 details
NFE2L2ELF1IntAct32911434 details
NFE2L2CHD6HPRD16314513 details
NFE2L2APEX1IntAct32911434 details
NFE2L2ETV4IntAct32911434 details
NFE2L2GATA1IntAct32911434 details
NFE2L2FBXW11BioGRID, IntAct25332235 25515538 32911434 details
NFE2L2CDKN1ABioGRID19560419 details
NFE2L2RNF4BioGRID23543742 details
NFE2L2USP9XBioGRID32442538 details
NFE2L2ESRRBIntAct17920186 details
NFE2L2PMLMINT28777872 details
NFE2L2MAPK9BioGRID24704364 details
NFE2L2HDAC3BioGRID22308472 details
NFE2L2PAQR3BioGRID27212020 details
NFE2L2TUBBBioGRID32416241 details
NFE2L2EEF1GMINT21597468 details
NFE2L2BTRCBioGRID, IntAct25900982 26091241 31220549 32911434 details
NFE2L2USP17L2BioGRID30778200 details
NFE2L2CUL3BioGRID15367669 15601839 details
NFE2L2BACH1BioGRID15734732 details
NFE2L2NCOR1BioGRID15870285 details
NFE2L2GADD45GIP1BioGRID20427290 details
NFE2L2NQO1BioGRID24140708 details
NFE2L2TRIM28BioGRID25995248 details
NFE2L2YY1BioGRID20309604 details
NFE2L2LMNABioGRID31687081 details
NFE2L2SIAH2BioGRID23645672 details
NFE2L2PPP1R13LBioGRID29033244 details
NFE2L2ACTBBioGRID32416241 details
NFE2L2MAFBioGRID26078718 details
NFE2L2RNF111BioGRID29597191 details
NFE2L2H3C1BioGRID31687081 details
NFE2L2RARADIP18048326 details
NFE2L2PPARGHPRD10930400 details
NFE2L2HDAC1BioGRID22308472 details
NFE2L2HDAC2BioGRID22308472 details
NFE2L2MYCBioGRID20232342 22942279 details
NFE2L2DCAF1BioGRID32171724 details
NFE2L2EP300BioGRID32057361 details
NFE2L2SQSTM1BioGRID, IntAct20421418 20452972 details
NFE2L2PMF1-BGLAPIntAct32911434 details
NFE2L2MAP2K1BioGRID24704364 details
NFE2L2RBM45BioGRID25939382 details
NFE2L2NCF1BioGRID28939422 details
NFE2L2JUNDHPRD9872330 details
NFE2L2UBCBioGRID25742418 details
NFE2L2PRKCDHPRD12198130 details
NFE2L2BRCA1BioGRID23857982 details
NFE2L2MAP2K2BioGRID24704364 details
NFE2L2DUSP1BioGRID31811110 details
NFE2L2AKT1BioGRID24704364 details
NFE2L2SMARCA4BioGRID16923960 details
NFE2L2PGAM5BioGRID18387606 details
NFE2L2AHRBioGRID20395535 details
NFE2L2TCF20BioGRID24416372 details
NFE2L2ATRAIDBioGRID, IntAct29792731 details
NFE2L2H2BC9BioGRID, IntAct30021884 details
NFE2L2ASTN1UniProt31169361 details
NFE2L2H4C1BioGRID30804502 details
NFE2L2HNRNPDBioGRID, IntAct30021884 details
NFE2L2HYOU1IntAct26700459 details