Entity Details

Primary name FXYD2
Entity type gene
Source Source Link

Details

PrimaryID486
RefseqGeneNG_011543
SymbolFXYD2
NameFXYD domain containing ion transport regulator 2
Chromosome11
Location11q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-23
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsATNG_HUMAN

GO terms

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GOName
GO:0001671 ATPase activator activity
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0017080 sodium channel regulator activity
GO:0030674 protein-macromolecule adaptor activity
GO:0034220 ion transmembrane transport
GO:0036376 sodium ion export across plasma membrane
GO:0055085 transmembrane transport
GO:0070062 extracellular exosome
GO:0099106 ion channel regulator activity
GO:1903408 positive regulation of P-type sodium:potassium-exchanging transporter activity
GO:1903779 regulation of cardiac conduction
GO:1990573 potassium ion import across plasma membrane
GO:2000649 regulation of sodium ion transmembrane transporter activity

Diseases

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Disease IDSourceNameDescription
154020 OMIMHypomagnesemia 2 (HOMG2)A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
FXYD2SGTABioGRID, IntAct32296183 details
FXYD2ERGIC3BioGRID, IntAct32296183 details
FXYD2SLC22A1BioGRID31318583 details
FXYD2SLC22A2BioGRID31318583 details