Entity Details

Primary name PKN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16512
EntryNamePKN1_HUMAN
FullNameSerine/threonine-protein kinase N1
TaxID9606
Evidenceevidence at protein level
Length942
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPKN1

GO terms

Show/Hide Table
GOName
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0002634 regulation of germinal center formation
GO:0002637 regulation of immunoglobulin production
GO:0003014 renal system process
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0007257 obsolete activation of JUN kinase activity
GO:0010631 epithelial cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0030374 nuclear receptor coactivator activity
GO:0030496 midbody
GO:0030889 negative regulation of B cell proliferation
GO:0031267 small GTPase binding
GO:0032154 cleavage furrow
GO:0032991 protein-containing complex
GO:0035402 histone kinase activity (H3-T11 specific)
GO:0035407 histone H3-T11 phosphorylation
GO:0035556 intracellular signal transduction
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0048536 spleen development
GO:0050681 androgen receptor binding
GO:0060765 regulation of androgen receptor signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000145 regulation of cell motility

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cleavage furrow
Cytoplasm
Endosome
Midbody
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011072 HR1 rho-binding domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR036274 HR1 repeat superfamilyFamilyHomologous superfamily
IPR037313 Serine/threonine-protein kinase N, first HR1 domainDomainDomain
IPR037317 Serine/threonine-protein kinase N1, second HR1 domainDomainDomain
IPR037784 Serine/threonine-protein kinase N, C2 domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

115 interactions

InteractorPartnerSourcesPublicationsLink
PKN1_HUMANRHOA_HUMANBioGRID, HPRD, MINT10619026 12773565 8571127 9446575 9535835 details
PKN1_HUMANMK12_HUMANBioGRID, HPRD, IntAct12761180 details
PKN1_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
PKN1_HUMANHOME3_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
PKN1_HUMANBUD23_HUMANBioGRID, IntAct21988832 details
PKN1_HUMANSPR2D_HUMANBioGRID, MINT21900206 details
PKN1_HUMANZN282_HUMANBioGRID, MINT21900206 details
PKN1_HUMANTRI18_HUMANBioGRID, IntAct25416956 details
PKN1_HUMANVIME_HUMANBioGRID, HPRD, IntAct25416956 9175763 details
PKN1_HUMANK1C15_HUMANBioGRID, IntAct25416956 details
PKN1_HUMANCDR2_HUMANBioGRID, HPRD, IntAct25416956 32296183 9637778 details
PKN1_HUMANGOGA2_HUMANBioGRID, IntAct25416956 32296183 details
PKN1_HUMANK1H1_HUMANBioGRID, IntAct25416956 32296183 details
PKN1_HUMANCE57L_HUMANBioGRID, IntAct25416956 details
PKN1_HUMANADIP_HUMANBioGRID, IntAct25416956 details
PKN1_HUMANDYDC1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANK1328_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANPNMA1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANMIPO1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANSTX11_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANKRT35_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANSRTD3_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANK1C16_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANMTUS2_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANTSG10_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANKRT37_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANUSBP1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANCEP70_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANTRI27_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANIKZF3_HUMANIntAct32296183 details
PKN1_HUMANNFL_HUMANBioGRID, HPRD, IntAct32296183 8621664 details
PKN1_HUMANAKP8L_HUMANIntAct32296183 details
PKN1_HUMANARSA_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANSTMN3_HUMANIntAct32296183 details
PKN1_HUMANZFP90_HUMANIntAct32296183 details
PKN1_HUMANCC103_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANKRT36_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANSYCE3_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANSMYD3_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANLRC61_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANUBR2_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANCEP57_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANSPAG5_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct14741690 32296183 details
PKN1_HUMANGO45_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANHAP1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANRAB3I_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANTRAF1_HUMANBioGRID, IntAct18429822 32296183 details
PKN1_HUMANDISC1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANK1C19_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANATL4_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANCC138_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANPSB4_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANINT11_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANHAUS1_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANEIF3F_HUMANBioGRID, IntAct32296183 details
PKN1_HUMANKCD17_HUMANIntAct32814053 details
PKN1_HUMANCCNJL_HUMANIntAct32814053 details
PKN1_HUMANMIER1_HUMANIntAct32814053 details
PKN1_HUMANZN488_HUMANIntAct32814053 details
PKN1_HUMANTHAP3_HUMANIntAct32814053 details
PKN1_HUMANZN581_HUMANIntAct32814053 details
PKN1_HUMANBECN1_HUMANIntAct32814053 details
PKN1_HUMANZN232_HUMANIntAct32814053 details
PKN1_HUMANGABP1_HUMANIntAct32814053 details
PKN1_HUMANEF1G_HUMANIntAct32814053 details
PKN1_HUMANCB015_HUMANIntAct32814053 details
PKN1_HUMANA4_HUMANIntAct32814053 details
PKN1_HUMANNFH_HUMANBioGRID, HPRD8621664 details
PKN1_HUMANACTN1_HUMANBioGRID, HPRD11802708 9030526 details
PKN1_HUMANPLD1_HUMANBioGRID, HPRD11259428 details
PKN1_HUMANNDF2_HUMANBioGRID, HPRD10640683 details
PKN1_HUMANAKAP9_HUMANBioGRID10358086 32296183 details
PKN1_HUMANPDPK1_HUMANBioGRID, HPRD10753910 10764742 10792047 details
PKN1_HUMANHDAC5_HUMANBioGRID20188095 details
PKN1_HUMANH32_HUMANBioGRID18066052 details
PKN1_HUMANPKN1_HUMANBioGRID, HPRD10467162 10792047 14741690 details
PKN1_HUMANCCNT2_HUMANBioGRID, HPRD16331689 details
PKN1_HUMANCASP3_HUMANBioGRID, HPRD9751706 details
PKN1_HUMANTAU_HUMANBioGRID, HPRD11104762 12387894 12435421 9199504 9546672 9832145 details
PKN1_HUMANTNR1B_HUMANBioGRID18429822 details
PKN1_HUMANMARCS_HUMANBioGRID, HPRD11930178 8557118 details
PKN1_HUMANMPIP3_HUMANBioGRID, HPRD15791647 details
PKN1_HUMANMBP_HUMANBioGRID15791647 details
PKN1_HUMANCC136_HUMANBioGRID32296183 details
PKN1_HUMANMK14_HUMANIntAct12761180 details
PKN1_HUMANMP2K3_HUMANBioGRID, IntAct12761180 details
PKN1_HUMANMP2K6_HUMANBioGRID, HPRD, IntAct12761180 details
PKN1_HUMANM3K20_HUMANIntAct12761180 details
PKN1_HUMANHS90B_HUMANIntAct22939624 details
PKN1_HUMANKPCB_HUMANDIP20228790 details
PKN1_HUMANAKT1_HUMANDIP23223530 details
PKN1_HUMANPDK1_HUMANBioGRID10753910 details
PKN1_HUMANTBA1A_HUMANBioGRID12716939 details
PKN1_HUMANTBB5_HUMANBioGRID12716939 details
PKN1_HUMANMK11_HUMANBioGRID12761180 details
PKN1_HUMANPA2G4_HUMANBioGRID19037095 details
PKN1_HUMANWDR5_HUMANBioGRID24793694 details
PKN1_HUMANKMT2A_HUMANBioGRID24793694 details
PKN1_HUMANRBBP5_HUMANBioGRID24793694 details
PKN1_HUMANASH2L_HUMANBioGRID24793694 details
PKN1_HUMANKBTB8_HUMANBioGRID26399832 29999490 30190310 details
PKN1_HUMANRHG26_HUMANHPRD11432776 details
PKN1_HUMANRHG10_HUMANHPRD11432776 details
PKN1_HUMANZFAN6_HUMANHPRD11054541 details
PKN1_HUMANCD44_HUMANHPRD15123640 details