Entity Details

Primary name PCKGM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16822
EntryNamePCKGM_HUMAN
FullNamePhosphoenolpyruvate carboxykinase [GTP], mitochondrial
TaxID9606
Evidenceevidence at protein level
Length640
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPCK2

GO terms

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GOName
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006094 gluconeogenesis
GO:0006107 oxaloacetate metabolic process
GO:0006116 NADH oxidation
GO:0019543 propionate catabolic process
GO:0030145 manganese ion binding
GO:0032024 positive regulation of insulin secretion
GO:0032496 response to lipopolysaccharide
GO:0032869 cellular response to insulin stimulus
GO:0033993 response to lipid
GO:0042594 response to starvation
GO:0046327 glycerol biosynthetic process from pyruvate
GO:0070365 hepatocyte differentiation
GO:0071333 cellular response to glucose stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071549 cellular response to dexamethasone stimulus

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilisingFamilyFamily
IPR008210 Phosphoenolpyruvate carboxykinase, N-terminalFamilyHomologous superfamily
IPR013035 Phosphoenolpyruvate carboxykinase, C-terminalFamilyHomologous superfamily
IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved siteSiteConserved site
IPR035077 Phosphoenolpyruvate carboxykinase, C-terminal P-loop domainDomainDomain
IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00787 AcyclovirDrugbanksmall molecule

Interactions

4 interactions