Entity Details

Primary name LTC4S_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16873
EntryNameLTC4S_HUMAN
FullNameLeukotriene C4 synthase
TaxID9606
Evidenceevidence at protein level
Length150
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesLTC4S

GO terms

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GOName
GO:0004364 glutathione transferase activity
GO:0004464 leukotriene-C4 synthase activity
GO:0004602 glutathione peroxidase activity
GO:0005635 nuclear envelope
GO:0005640 nuclear outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006691 leukotriene metabolic process
GO:0008047 enzyme activator activity
GO:0008289 lipid binding
GO:0016021 integral component of membrane
GO:0019370 leukotriene biosynthetic process
GO:0019372 lipoxygenase pathway
GO:0031965 nuclear membrane
GO:0042759 long-chain fatty acid biosynthetic process
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:2001301 lipoxin biosynthetic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Nucleus membrane
Nucleus outer membrane

Domains

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DomainNameCategoryType
IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) proteinFamilyFamily
IPR001446 5-lipoxygenase-activating proteinFamilyFamily
IPR018295 FLAP/GST2/LTC4S, conserved siteSiteConserved site
IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule