Entity Details

Primary name DOXA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ1HG44
EntryNameDOXA2_HUMAN
FullNameDual oxidase maturation factor 2
TaxID9606
Evidenceevidence at protein level
Length320
SequenceStatuscomplete
DateCreated2006-12-12
DateModified2021-06-02

Ontological Relatives

GenesDUOXA2

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008104 protein localization
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process
GO:0015031 protein transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019899 enzyme binding
GO:0031252 cell leading edge
GO:0034613 cellular protein localization
GO:0042743 hydrogen peroxide metabolic process
GO:0045177 apical part of cell
GO:0050727 regulation of inflammatory response
GO:0051604 protein maturation
GO:2000147 positive regulation of cell motility
GO:2000609 regulation of thyroid hormone generation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR018469 Dual oxidase maturation factorFamilyFamily

Diseases

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Disease IDSourceNameDescription
274900 OMIMThyroid dyshormonogenesis 5 (TDH5)A disorder due to thyroid dyshormonogenesis, causing hypothyroidism, goiter, and variable mental deficits derived from unrecognized and untreated hypothyroidism. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
DOXA2_HUMANDUOX2_HUMANUniProt25761904 details