Entity Details

Primary name MAP2K2
Entity type gene
Source Source Link

Details

PrimaryID5605
RefseqGeneNG_007996
SymbolMAP2K2
Namemitogen-activated protein kinase kinase 2
Chromosome19
Location19p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-14
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMP2K2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0010629 negative regulation of gene expression
GO:0030165 PDZ domain binding
GO:0032872 regulation of stress-activated MAPK cascade
GO:0036289 peptidyl-serine autophosphorylation
GO:0043539 protein serine/threonine kinase activator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0070371 ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Diseases

Show/Hide Table

Interactions

92 interactions

InteractorPartnerSourcesPublicationsLink
MAP2K2ARAFBioGRID, HPRD, IntAct11909642 21988832 24746704 25852190 31980649 32296183 details
MAP2K2RAF1BioGRID, HPRD, IntAct11909642 16364241 19058874 21988832 24746704 31980649 8157000 8393135 9671314 9808624 details
MAP2K2MAP2K2BioGRID, HPRD, IntAct11909642 17192257 31980649 8226933 details
MAP2K2KSR1BioGRID, IntAct11909642 27086506 31980649 details
MAP2K2COPS5BioGRID, IntAct18624398 20936779 details
MAP2K2ZNF207BioGRID, IntAct21988832 details
MAP2K2RIPOR2BioGRID, IntAct21988832 details
MAP2K2DLG1MINT21615688 details
MAP2K2CCNDBP1BioGRID, IntAct25416956 details
MAP2K2HNRNPKBioGRID, IntAct32296183 details
MAP2K2MOSBioGRID, IntAct32296183 details
MAP2K2APPIntAct32814053 details
MAP2K2MAPK1BioGRID, HPRD, IntAct11134045 11823456 12788955 21675959 23519423 details
MAP2K2MAPK3BioGRID, HPRD7687743 8226933 8626767 9006895 details
MAP2K2MAPK8BioGRID16533805 details
MAP2K2LIG4BioGRID22990118 details
MAP2K2CNKSR1HPRD9427625 details
MAP2K2RGS12HPRD17380122 details
MAP2K2MCCIntAct17353931 details
MAP2K2BRAFBioGRID, HPRD, IntAct17979178 24746704 25600339 27034005 28514442 31980649 8668348 details
MAP2K2YWHABBioGRID, IntAct10409742 24255178 31980649 details
MAP2K2MAP2K1BioGRID, IntAct10409742 28514442 details
MAP2K2WDR83BioGRID15118098 details
MAP2K2IQGAP1BioGRID24639526 details
MAP2K2NFE2L2BioGRID24704364 details
MAP2K2DUSP3HPRD10224087 details
MAP2K2CASP9HPRD12792650 details
MAP2K2GRIN2DHPRD10862698 details
MAP2K2LAMTOR3HPRD9733512 details
MAP2K2GRIN1HPRD10862698 details
MAP2K2SNW1BioGRID, MINT20467437 details
MAP2K2PEX14BioGRID, IntAct21525035 details
MAP2K2PKMIntAct24606918 details
MAP2K2HSCBBioGRID, IntAct28380382 details
MAP2K2KSR2IntAct27086506 details
MAP2K2CD70BioGRID, IntAct28514442 details
MAP2K2SERPINB2BioGRID, IntAct28514442 details
MAP2K2HSPA8BioGRID, IntAct28514442 31980649 details
MAP2K2NOCTBioGRID, IntAct28514442 details
MAP2K2TUBA4ABioGRID, IntAct28514442 31980649 details
MAP2K2DLDBioGRID, IntAct29128334 details
MAP2K2LRRK2IntAct31046837 details
MAP2K2BAG2BioGRID, IntAct31980649 details
MAP2K2EIF2S1BioGRID, IntAct31980649 details
MAP2K2TUBBBioGRID, IntAct31980649 details
MAP2K2HSP90AA1BioGRID, IntAct31980649 details
MAP2K2HSP90AB1BioGRID, IntAct31980649 details
MAP2K2HSPA5BioGRID, IntAct31980649 details
MAP2K2NCLBioGRID, IntAct31980649 details
MAP2K2YWHAQBioGRID, IntAct31980649 details
MAP2K2HSPA4BioGRID, IntAct31980649 details
MAP2K2HSPA9BioGRID, IntAct31980649 details
MAP2K2YWHAZBioGRID, IntAct31980649 details
MAP2K2TUBA1BBioGRID, IntAct31980649 details
MAP2K2TUBB4BBioGRID, IntAct31980649 details
MAP2K2SLC25A3BioGRID, IntAct31980649 details
MAP2K2SLC25A11BioGRID, IntAct31980649 details
MAP2K2YWHAHBioGRID, IntAct31980649 details
MAP2K2CDC37BioGRID, IntAct31980649 details
MAP2K2IMMTBioGRID, IntAct31980649 details
MAP2K2TUBA1CBioGRID, IntAct31980649 details
MAP2K2MAP4K1BioGRID, IntAct31980649 details
MAP2K2DNAJA2BioGRID, IntAct31980649 details
MAP2K2HPXBioGRID, IntAct31980649 details
MAP2K2DSPBioGRID, IntAct31980649 details
MAP2K2DNAJA1BioGRID, IntAct31980649 details
MAP2K2CCT6ABioGRID, IntAct31980649 details
MAP2K2DSG1BioGRID, IntAct31980649 details
MAP2K2PRDX1BioGRID, IntAct31980649 details
MAP2K2MEPCEBioGRID17643375 details
MAP2K2EGFRBioGRID24797263 details
MAP2K2ART3BioGRID26186194 details
MAP2K2ACTL6ABioGRID26186194 details
MAP2K2TNFBioGRID26186194 details
MAP2K2PDLIM5BioGRID26344197 details
MAP2K2RPEBioGRID26344197 details
MAP2K2TXNBioGRID26344197 details
MAP2K2XPO1BioGRID26673895 details
MAP2K2BMPR1ABioGRID27684187 details
MAP2K2CDK9BioGRID27684187 details
MAP2K2TPT1BioGRID28846114 details
MAP2K2NR2C2BioGRID30463901 details
MAP2K2PGRMC1BioGRID31067491 details
MAP2K2UBCBioGRID27182664 details
MAP2K2PLEKHA4BioGRID31091453 details
MAP2K2NR3C1BioGRID31182584 details
MAP2K2FAM20CBioGRID32149426 details
MAP2K2HSPA1ABioGRID, IntAct31980649 details
MAP2K2HSPA1BIntAct31980649 details
MAP2K2TRIM25BioGRID29117863 details
MAP2K2HNRNPLBioGRID28611215 details
MAP2K2DDX58BioGRID32513696 details