Entity Details
| Primary name |
TRM5_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q32P41 |
| EntryName | TRM5_HUMAN |
| FullName | tRNA (guanine(37)-N1)-methyltransferase |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 509 |
| SequenceStatus | complete |
| DateCreated | 2006-10-31 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Cytoplasm |
| Mitochondrion matrix |
| Nucleus |
Domains
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| Domain | Name | Category | Type |
| IPR025792 | tRNA (guanine(37)-N(1))-methyltransferase, eukaryotic | Family | Family |
| IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase | Family | Homologous superfamily |
| IPR030382 | SAM-dependent methyltransferase TRM5/TYW2-type | Domain | Domain |
Diseases
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| Disease ID | Source | Name | Description |
| 616539 | OMIM | Combined oxidative phosphorylation deficiency 26 (COXPD26) | A mitochondrial disorder characterized by lactic acidosis, multiple mitochondrial respiratory-chain-complex deficiencies in skeletal muscle, and additional variable features including hypertrophic cardiomyopathy, exercise intolerance, and failure to thrive. The disease is caused by variants affecting the gene represented in this entry. |
Interactions
1 interaction