Entity Details

Primary name TOP2A
Entity type gene
Source Source Link

Details

PrimaryID7153
RefseqGeneNG_027678
SymbolTOP2A
NameDNA topoisomerase II alpha
Chromosome17
Location17q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1992-03-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTOP2A_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000712 resolution of meiotic recombination intermediates
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0007143 female meiotic nuclear division
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008301 DNA binding, bending
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0019899 enzyme binding
GO:0030263 apoptotic chromosome condensation
GO:0032991 protein-containing complex
GO:0040016 embryonic cleavage
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048511 rhythmic process
GO:1905463 negative regulation of DNA duplex unwinding
GO:1990904 ribonucleoprotein complex

Diseases

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Interactions

205 interactions

InteractorPartnerSourcesPublicationsLink
TOP2ACTNNB1BioGRID, IntAct16230076 17983804 27684187 details
TOP2ACSNK2A1BioGRID, HPRD, IntAct11940573 21254166 22113938 26344197 8939955 9804834 details
TOP2APRKCDIntAct16611985 details
TOP2AJUNBioGRID, HPRD, MINT25609649 8387155 details
TOP2ABRCA1BioGRID, DIP, HPRD15965487 25184681 details
TOP2AHDAC1BioGRID, HPRD11062478 11136718 details
TOP2ATOP2BBioGRID, HPRD22939629 8710863 details
TOP2ATP53BioGRID, HPRD10666337 32807901 details
TOP2ADFFBBioGRID, HPRD10959840 details
TOP2ACDT1BioGRID18162579 details
TOP2AMAPK1BioGRID10207078 details
TOP2ACOPS5BioGRID15126503 21254166 details
TOP2APRKCABioGRID, HPRD12569090 7499337 details
TOP2APRKCBBioGRID, HPRD12569090 7499337 details
TOP2APRKCGBioGRID, HPRD12569090 7499337 details
TOP2AUBE2IBioGRID10862613 19596686 details
TOP2APIAS4BioGRID20696768 details
TOP2ASUMO2BioGRID19394292 32786267 details
TOP2AUHRF1BioGRID25451918 details
TOP2APLK1BioGRID18695677 details
TOP2ARNF168BioGRID27558965 details
TOP2ASMURF2BioGRID28611047 details
TOP2AFBXO28BioGRID27754753 details
TOP2AMDM4BioGRID30672125 details
TOP2APIN1BioGRID, HPRD, MINT11940573 details
TOP2ARANBP2BioGRID, IntAct18394993 26344197 details
TOP2AXRCC5BioGRID, IntAct12393188 20085707 details
TOP2AFOXM1DIP15965487 details
TOP2AXPO1DIP, HPRD12821127 19955415 details
TOP2AARID1ADIP23698369 details
TOP2ASMARCA4DIP23698369 details
TOP2ADHX9BioGRID, HPRD12711669 15034300 details
TOP2AHDAC2BioGRID, HPRD11062478 details
TOP2AYWHAEBioGRID, HPRD10788521 details
TOP2ACDC5LBioGRID11101529 20467437 details
TOP2ANR4A1BioGRID19321449 details
TOP2ASETMARBioGRID18790802 19458360 details
TOP2AH3C6BioGRID20504901 details
TOP2AH3-3ABioGRID20504901 details
TOP2ABMI1BioGRID19956605 details
TOP2ARING1BioGRID19956605 details
TOP2ACTCFBioGRID14759373 details
TOP2ASMARCAD1BioGRID21549307 details
TOP2ACUL2BioGRID19695223 details
TOP2AELOCBioGRID19695223 details
TOP2AVHLBioGRID19695223 details
TOP2AFBXW7BioGRID21254166 details
TOP2AGSK3BBioGRID21254166 details
TOP2ABLMBioGRID19329795 details
TOP2ATERF2BioGRID19329795 details
TOP2ARB1BioGRID, HPRD10393912 details
TOP2ASRPK1BioGRID, HPRD15034300 details
TOP2AITGA4BioGRID22623428 details
TOP2ARAC1BioGRID19961560 details
TOP2AKMT2EBioGRID26678539 details
TOP2AAHSA1BioGRID22504172 details
TOP2AERCC6BioGRID26030138 details
TOP2ATOP2ABioGRID9972548 details
TOP2AMRE11BioGRID31967940 details
TOP2ACDK1HPRD12569090 7635160 details
TOP2ASUMO4HPRD16236267 details
TOP2ASUMO1HPRD10862613 12832072 details
TOP2ADDX21IntAct15034300 details
TOP2ATOP1BioGRID, IntAct15848144 26344197 details
TOP2AMYCBioGRID, IntAct17314511 29467282 details
TOP2ATCF4IntAct17983804 details
TOP2AH2AXIntAct20085707 details
TOP2APARP1BioGRID, IntAct20085707 34079125 details
TOP2APRKDCIntAct20085707 details
TOP2AAIREBioGRID, IntAct20085707 details
TOP2AESR1BioGRID, IntAct21182205 details
TOP2AVCAM1BioGRID, IntAct19738201 22623428 details
TOP2ACUL5BioGRID, IntAct21145461 details
TOP2AYY1MINT23531880 details
TOP2AFOXD3BioGRID, MINT25609649 details
TOP2AFOXP1BioGRID, MINT25609649 details
TOP2ACKAP5BioGRID, IntAct26496610 details
TOP2ARNF2BioGRID, IntAct26496610 details
TOP2ATFGBioGRID, IntAct26496610 details
TOP2ARPL10BioGRID, IntAct26496610 details
TOP2AL3MBTL3BioGRID, IntAct26496610 details
TOP2ANOP56BioGRID, IntAct26496610 details
TOP2ADAXXBioGRID, IntAct26496610 details
TOP2AHNRNPUBioGRID, IntAct26496610 details
TOP2ASPICE1BioGRID, IntAct26638075 details
TOP2AGPR75-ASB3IntAct28514442 details
TOP2AASB3BioGRID, IntAct28514442 details
TOP2ATHBS3BioGRID, IntAct26186194 28514442 details
TOP2AFAM131BBioGRID, IntAct28514442 details
TOP2AHSD3B2BioGRID, IntAct28514442 details
TOP2ARBM4BBioGRID, IntAct26186194 28514442 details
TOP2AINTUBioGRID, IntAct28514442 details
TOP2AAGO2DIP19955415 details
TOP2ACOX15BioGRID, IntAct29128334 details
TOP2ADLSTBioGRID, IntAct29128334 details
TOP2AMETTL14BioGRID, UniProt29507755 details
TOP2ASMARCB1IntAct30108113 details
TOP2AMAGT1BioGRID, IntAct30021884 details
TOP2AH2BC9BioGRID, IntAct30021884 details
TOP2ADHX16BioGRID, IntAct30021884 details
TOP2AFBXL13BioGRID, IntAct30021884 details
TOP2ARESF1BioGRID, IntAct30021884 details
TOP2AH3-4BioGRID, IntAct30021884 details
TOP2AL1TD1MINT25702638 details
TOP2ASCARB2BioGRID, IntAct30833792 details
TOP2AHMGB1BioGRID, UniProt29721183 details
TOP2AAKAP8LMINT21715506 details
TOP2ANCBP1IntAct32960270 details
TOP2ANCBP2IntAct32960270 details
TOP2ANDNBioGRID, MINT32529326 details
TOP2AISG15BioGRID16009940 details
TOP2AUPF3BBioGRID22939629 details
TOP2ACSNK2A2BioGRID22939629 details
TOP2AFN1BioGRID19738201 details
TOP2ALMNABioGRID22412018 34079125 details
TOP2ARPA3BioGRID24332808 details
TOP2ARPA2BioGRID24332808 details
TOP2ARPA1BioGRID24332808 details
TOP2AEIF6BioGRID24778252 details
TOP2ACUL7BioGRID24711643 details
TOP2AOBSL1BioGRID24711643 details
TOP2ACCDC8BioGRID24711643 31343991 details
TOP2ACSNK2BBioGRID26344197 details
TOP2AGLYR1BioGRID26344197 details
TOP2APATL1BioGRID26344197 details
TOP2ASSRP1BioGRID26344197 details
TOP2ANOP2BioGRID26344197 details
TOP2AIFI16BioGRID25693804 details
TOP2AMCM5BioGRID25963833 details
TOP2ACDH19BioGRID28514442 details
TOP2AVDAC1BioGRID29128334 details
TOP2AFOXA1BioGRID27926873 details
TOP2ACFTRBioGRID26618866 details
TOP2AHBP1BioGRID29911972 details
TOP2APYHIN1BioGRID28077445 details
TOP2AEFTUD2BioGRID28515276 details
TOP2ANKX2-1BioGRID28192407 details
TOP2ARNF4BioGRID29180619 32521226 details
TOP2ACHD3BioGRID28977666 details
TOP2ACHD4BioGRID28977666 details
TOP2AMINDY4BioGRID29795372 details
TOP2AMYO6BioGRID29467281 details
TOP2AEZH2BioGRID27634302 details
TOP2AZBTB38BioGRID29490077 details
TOP2ADCPSBioGRID29478914 details
TOP2AH4C1BioGRID27248496 30804502 details
TOP2AH2AC4BioGRID27248496 details
TOP2AGRWD1BioGRID29991511 details
TOP2AATG16L1BioGRID30196744 details
TOP2ANR2C2BioGRID30463901 details
TOP2AXRCC6BioGRID30585729 details
TOP2ANINLBioGRID28718761 details
TOP2AVRK1BioGRID28927264 details
TOP2ASNRNP70BioGRID29802200 details
TOP2ABIRC3BioGRID30948266 details
TOP2ASTAU1BioGRID30948266 details
TOP2AWWP2BioGRID31048545 details
TOP2APAK5BioGRID31219614 details
TOP2ATRIM28BioGRID29955894 details
TOP2AEP300BioGRID30110629 details
TOP2APLEKHA4BioGRID31091453 details
TOP2ARAD18BioGRID31076518 details
TOP2ANSD2BioGRID31248990 details
TOP2AFANCD2BioGRID31180492 details
TOP2AZC3H18BioGRID29298432 details
TOP2AMN1BioGRID31839203 details
TOP2ACITBioGRID31586073 details
TOP2AANLNBioGRID31586073 details
TOP2AAURKBBioGRID31586073 details
TOP2ACHMP4BBioGRID31586073 details
TOP2ACHMP4CBioGRID31586073 details
TOP2AECT2BioGRID31586073 details
TOP2AKIF14BioGRID31586073 details
TOP2AKIF20ABioGRID31586073 details
TOP2AKIF23BioGRID31586073 details
TOP2APRC1BioGRID31586073 details
TOP2ATRIM24BioGRID31753913 details
TOP2AMTRFRBioGRID32877691 details
TOP2ACHCHD1BioGRID32877691 details
TOP2AZNF263BioGRID32051553 details
TOP2ABRD4BioGRID31239290 32416067 details
TOP2ANUPR1BioGRID32780723 details
TOP2ARBM39BioGRID28302793 details
TOP2AFBP1BioGRID32041737 details
TOP2ALGALS9BioGRID31995728 details
TOP2AMKRN1BioGRID32460013 details
TOP2AMKRN2BioGRID32460013 details
TOP2AGLE1BioGRID32460013 details
TOP2ASIRT7BioGRID32711345 details
TOP2ADDRGK1BioGRID32807901 details
TOP2ACBX3BioGRID34079125 details
TOP2APOLR1GBioGRID34079125 details
TOP2ACENPABioGRID34079125 details
TOP2ACOILBioGRID34079125 details
TOP2ADDX23BioGRID34079125 details
TOP2AFBLBioGRID34079125 details
TOP2AH2BC8BioGRID34079125 details
TOP2AH3C1BioGRID34079125 details
TOP2ARPL31BioGRID34079125 details
TOP2ARPS6BioGRID34079125 details
TOP2ATERF2IPBioGRID34079125 details
TOP2AZNF330BioGRID34079125 details
TOP2AUNKBioGRID25737280 details
TOP2AVIRMABioGRID29507755 details
TOP2AIGF2BP1BioGRID30581152 details