Entity Details

Primary name PAX8
Entity type gene
Source Source Link

Details

PrimaryID7849
RefseqGeneNG_012384
SymbolPAX8
Namepaired box 8
Chromosome2
Location2q14.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-05-07
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsPAX8_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001655 urogenital system development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007417 central nervous system development
GO:0009653 anatomical structure morphogenesis
GO:0030878 thyroid gland development
GO:0039003 pronephric field specification
GO:0042472 inner ear morphogenesis
GO:0042981 regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048793 pronephros development
GO:0048856 anatomical structure development
GO:0071371 cellular response to gonadotropin stimulus
GO:0071599 otic vesicle development
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072207 metanephric epithelium development
GO:0072221 metanephric distal convoluted tubule development
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072289 metanephric nephron tubule formation
GO:0072305 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215 negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218 negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000594 positive regulation of metanephric DCT cell differentiation
GO:2000611 positive regulation of thyroid hormone generation
GO:2000612 regulation of thyroid-stimulating hormone secretion

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
PAX8SERINC1BioGRID, IntAct20195357 details
PAX8ANXA7BioGRID, IntAct20195357 details
PAX8CHUKBioGRID, IntAct21988832 details
PAX8CXCL9BioGRID, IntAct21988832 details
PAX8PKMBioGRID, IntAct21988832 details
PAX8SMAD4IntAct27107012 details
PAX8HOXC9BioGRID, IntAct32296183 details
PAX8HOXC8BioGRID, IntAct32296183 details
PAX8LONRF1BioGRID, IntAct32296183 details
PAX8SAE1BioGRID, IntAct32296183 details
PAX8DOK4BioGRID, IntAct32296183 details
PAX8CDK3BioGRID, IntAct32296183 details
PAX8GCM2BioGRID, IntAct32296183 details
PAX8SS18L1BioGRID, IntAct32296183 details
PAX8TLE5BioGRID, IntAct32296183 details
PAX8POU2AF1BioGRID, IntAct20211142 details
PAX8NKX2-1BioGRID, HPRD12441357 14970209 details
PAX8EP300BioGRID, HPRD10924503 details
PAX8AURKABioGRID31391550 details
PAX8SKP2BioGRID31391550 details
PAX8NCLIntAct20195357 details
PAX8CLSTN1IntAct20195357 details
PAX8HSPA1AIntAct20195357 details
PAX8HSPA1BIntAct20195357 details
PAX8RSBN1IntAct20195357 details
PAX8TMA16IntAct20195357 details
PAX8UNKIntAct20195357 details
PAX8RPLP2IntAct20195357 details
PAX8RB1BioGRID, I2D21602887 details
PAX8SMAD3HPRD14623893 details
PAX8WBP2HPRD14531730 details
PAX8ID2HPRD11134340 details
PAX8LYARBioGRID31391550 details
PAX8ILF2BioGRID31391550 details
PAX8MKRN2BioGRID31391550 details
PAX8FBXO3BioGRID31391550 details
PAX8PARP1BioGRID31391550 details
PAX8E2F1I2D21602887 details
PAX8IL3IntAct33179750 details
PAX8IL36AIntAct33179750 details
PAX8TNFSF14IntAct33179750 details