Entity Details

Primary name CLOCK
Entity type gene
Source Source Link

Details

PrimaryID9575
RefseqGene
SymbolCLOCK
Nameclock circadian regulator
Chromosome4
Location4q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-04-23
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsCLOCK_HUMAN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005694 chromosome
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006473 protein acetylation
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0009648 photoperiodism
GO:0031490 chromatin DNA binding
GO:0032922 circadian regulation of gene expression
GO:0033391 chromatoid body
GO:0042634 regulation of hair cycle
GO:0042752 regulation of circadian rhythm
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0050729 positive regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051775 response to redox state
GO:0070888 E-box binding
GO:0071479 cellular response to ionizing radiation
GO:1990513 CLOCK-BMAL transcription complex
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000074 regulation of type B pancreatic cell development
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway

Diseases

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Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
CLOCKARNTLBioGRID, HPRD, IntAct11018023 11439184 14701734 19922678 20551151 23555304 26164627 27173435 28388406 28514442 30287810 31515488 32296183 9576906 9989497 unassigned1312 details
CLOCKARNTL2BioGRID, HPRD, IntAct10864977 11018023 14701734 28514442 32296183 details
CLOCKCIPCBioGRID, IntAct23555304 26186194 28514442 details
CLOCKCLOCKDIP24737000 details
CLOCKKMT2ADIP25751424 details
CLOCKCRY1BioGRID, IntAct, MINT23555304 28388406 32538895 details
CLOCKEP300BioGRID14645221 details
CLOCKKAT2BBioGRID14645221 details
CLOCKRXRABioGRID11439184 details
CLOCKRARABioGRID11439184 details
CLOCKSIRT1BioGRID18662547 details
CLOCKCRY2BioGRID23555304 31155351 details
CLOCKBHLHE41BioGRID23555304 details
CLOCKNPAS2BioGRID23555304 details
CLOCKPPP2R5DBioGRID23555304 details
CLOCKPPP2R5EBioGRID23555304 details
CLOCKCSNK2BBioGRID23555304 details
CLOCKPPP2R1BBioGRID23555304 details
CLOCKNR1D2BioGRID23555304 details
CLOCKPER2BioGRID23555304 details
CLOCKPPP1CABioGRID23555304 details
CLOCKPPP1CBBioGRID23555304 details
CLOCKPPP1CCBioGRID23555304 details
CLOCKCSNK1EBioGRID23555304 details
CLOCKDBPBioGRID23555304 details
CLOCKRORCBioGRID23555304 details
CLOCKRHOABioGRID30287810 details
CLOCKMAXBioGRID, IntAct27173435 unassigned1312 details
CLOCKYEATS4BioGRID, IntAct27173435 unassigned1312 details
CLOCKKDM1ABioGRID, IntAct27173435 unassigned1312 details
CLOCKOIP5BioGRID, IntAct27173435 unassigned1312 details
CLOCKPSMD9BioGRID, IntAct27173435 unassigned1312 details
CLOCKRABGAP1LBioGRID, IntAct27173435 unassigned1312 details
CLOCKTFPTBioGRID, IntAct27173435 unassigned1312 details
CLOCKRCOR1BioGRID, IntAct27173435 unassigned1312 details
CLOCKVPS51BioGRID, IntAct27173435 unassigned1312 details
CLOCKHMG20ABioGRID, IntAct27173435 unassigned1312 details
CLOCKTUFT1BioGRID, IntAct27173435 unassigned1312 details
CLOCKNCKAP5LBioGRID, IntAct27173435 unassigned1312 details
CLOCKNUF2BioGRID, IntAct27173435 unassigned1312 details
CLOCKTHAP11BioGRID, IntAct27173435 unassigned1312 details
CLOCKPHF21ABioGRID, IntAct27173435 unassigned1312 details
CLOCKCCHCR1BioGRID, IntAct27173435 unassigned1312 details
CLOCKGOLGA5BioGRID, IntAct27173435 unassigned1312 details
CLOCKDZIP3BioGRID, IntAct27173435 unassigned1312 details
CLOCKHAUS6BioGRID, IntAct27173435 unassigned1312 details
CLOCKPHLDB3BioGRID, IntAct27173435 unassigned1312 details
CLOCKVPS53BioGRID, IntAct27173435 unassigned1312 details
CLOCKCCDC93BioGRID, IntAct27173435 unassigned1312 details
CLOCKEIPR1BioGRID, IntAct27173435 unassigned1312 details
CLOCKGRIPAP1BioGRID, IntAct27173435 unassigned1312 details
CLOCKRABEP1BioGRID, IntAct27173435 unassigned1312 details
CLOCKGIT2BioGRID, IntAct27173435 unassigned1312 details
CLOCKCAVIN1BioGRID, IntAct27173435 unassigned1312 details
CLOCKPKN3BioGRID, IntAct27173435 unassigned1312 details
CLOCKVPS50BioGRID, IntAct27173435 unassigned1312 details
CLOCKRPRD1ABioGRID, IntAct27173435 unassigned1312 details
CLOCKRABGEF1BioGRID, IntAct27173435 unassigned1312 details
CLOCKCREBBPBioGRID26164627 details
CLOCKSTUB1BioGRID32041778 details
CLOCKPER3HPRD14701732 details
CLOCKSRGAP3BioGRID, IntAct26186194 28514442 details
CLOCKEXOC1BioGRID, IntAct28514442 details
CLOCKTEKT4BioGRID, IntAct26186194 28514442 details
CLOCKCIARTDIP24737000 details
CLOCKTP53BP1UniProt29656893 details
CLOCKSTAG2DIP29867216 details
CLOCKSOX2BioGRID, MINT23667531 details
CLOCKTFAP4BioGRID19505873 details
CLOCKH4C1BioGRID30804502 details