Entity Details

Primary name CD74
Entity type gene
Source Source Link

Details

PrimaryID972
RefseqGeneNG_029730
SymbolCD74
NameCD74 molecule
Chromosome5
Location5q33.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-06-11
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsHG2A_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000187 obsolete activation of MAPK activity
GO:0001516 prostaglandin biosynthetic process
GO:0001540 amyloid-beta binding
GO:0001934 positive regulation of protein phosphorylation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002286 T cell activation involved in immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002792 negative regulation of peptide secretion
GO:0002830 positive regulation of type 2 immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0004896 cytokine receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005773 vacuole
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0008283 cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016064 immunoglobulin mediated immune response
GO:0019882 antigen processing and presentation
GO:0019883 antigen processing and presentation of endogenous antigen
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019955 cytokine binding
GO:0023026 MHC class II protein complex binding
GO:0030336 negative regulation of cell migration
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030890 positive regulation of B cell proliferation
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0032588 trans-Golgi network membrane
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0034341 response to interferon-gamma
GO:0035691 macrophage migration inhibitory factor signaling pathway
GO:0035692 macrophage migration inhibitory factor receptor complex
GO:0035693 NOS2-CD74 complex
GO:0035718 macrophage migration inhibitory factor binding
GO:0042289 MHC class II protein binding
GO:0042609 CD4 receptor binding
GO:0042613 MHC class II protein complex
GO:0042658 MHC class II protein binding, via antigen binding groove
GO:0042802 identical protein binding
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043202 lysosomal lumen
GO:0043410 positive regulation of MAPK cascade
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044183 protein folding chaperone
GO:0045058 T cell selection
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046597 negative regulation of viral entry into host cell
GO:0046598 positive regulation of viral entry into host cell
GO:0048146 positive regulation of fibroblast proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0050900 leukocyte migration
GO:0050998 nitric-oxide synthase binding
GO:0051085 chaperone cofactor-dependent protein refolding
GO:0060907 positive regulation of macrophage cytokine production
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0070206 protein trimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000448 positive regulation of macrophage migration inhibitory factor signaling pathway

Diseases

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Interactions

158 interactions

InteractorPartnerSourcesPublicationsLink
CD74HADHABioGRID, IntAct21988832 30833792 details
CD74TEX11BioGRID, IntAct32296183 details
CD74SMIM1BioGRID, IntAct32296183 details
CD74POMGNT1BioGRID, IntAct32296183 details
CD74FXYD6BioGRID, IntAct32296183 details
CD74TMEM120BBioGRID, IntAct32296183 details
CD74SEC22ABioGRID, IntAct32296183 details
CD74RTP2BioGRID, IntAct32296183 details
CD74EDDM3BBioGRID, IntAct32296183 details
CD74FDFT1BioGRID, IntAct32296183 details
CD74CLDN19BioGRID, IntAct32296183 details
CD74LPAR3BioGRID, IntAct32296183 details
CD74CLEC7ABioGRID, IntAct32296183 details
CD74SLC35B1BioGRID, IntAct32296183 details
CD74PGA4BioGRID, IntAct32296183 details
CD74CMTM7BioGRID, IntAct32296183 details
CD74TMEM97BioGRID, IntAct32296183 details
CD74C14orf180BioGRID, IntAct32296183 details
CD74TMEM254BioGRID, IntAct32296183 details
CD74UPK2BioGRID, IntAct32296183 details
CD74PTCH1BioGRID, IntAct32296183 details
CD74ERG28BioGRID, IntAct32296183 details
CD74PLPP4BioGRID, IntAct32296183 details
CD74SERP1BioGRID, IntAct32296183 details
CD74PLP1BioGRID, IntAct32296183 details
CD74TMEM60BioGRID, IntAct32296183 details
CD74BET1BioGRID, IntAct32296183 details
CD74TMEM243BioGRID, IntAct32296183 details
CD74HSPA1AIntAct17357109 24428437 details
CD74HSPA1BIntAct17357109 24428437 details
CD74CD44BioGRID, HPRD, IntAct27872288 29190904 8343954 details
CD74CCR1BioGRID, MINT28298427 details
CD74ALG3UniProt29547901 details
CD74MIFBioGRID, HPRD12782713 details
CD74APPBioGRID21832049 details
CD74LAMTOR5BioGRID23241634 details
CD74MAP3K1BioGRID25260751 details
CD74HLA-DRAHPRD, MINT16242130 details
CD74HLA-DPA1HPRD, MINT16242130 details
CD74HLA-DQA1BioGRID, HPRD, IntAct, MINT16242130 25241761 details
CD74CXCR4MINT19665027 details
CD74HLA-DQB1HPRD, IntAct16242130 17629515 details
CD74KPNB1BioGRID, IntAct30833792 details
CD74EIF3EBioGRID, IntAct30833792 details
CD74HLA-DPB1BioGRID, HPRD, IntAct16242130 26186194 30833792 details
CD74CXCR2IntAct17435771 details
CD74CD74BioGRID, HPRD2391366 9752000 9843486 details
CD74CTSLHPRD10022822 details
CD74HLA-DMBHPRD8574855 details
CD74CD1DHPRD11754812 details
CD74CTSFHPRD10748235 details
CD74PEDS1-UBE2V1IntAct25260751 details
CD74UBE2V1IntAct25260751 details
CD74UBA1IntAct25260751 details
CD74UBE2NIntAct25260751 details
CD74TM4SF20BioGRID, IntAct26186194 28514442 details
CD74COPG1BioGRID, IntAct26186194 28514442 30833792 details
CD74COPG2BioGRID, IntAct26186194 28514442 30833792 details
CD74RHOT2BioGRID, IntAct30833792 details
CD74HUWE1BioGRID, IntAct30833792 details
CD74PRRC2CBioGRID, IntAct30833792 details
CD74EIF3LBioGRID, IntAct30833792 details
CD74PPP6R1BioGRID, IntAct30833792 details
CD74EIF2B4BioGRID, IntAct30833792 details
CD74TJP2BioGRID, IntAct30833792 details
CD74DNAJB11BioGRID, IntAct30833792 details
CD74EIF3KBioGRID, IntAct30833792 details
CD74DNAJB12BioGRID, IntAct30833792 details
CD74EIF2B3BioGRID, IntAct30833792 details
CD74RWDD1BioGRID, IntAct30833792 details
CD74TUBA1CBioGRID, IntAct30833792 details
CD74EIF3CBioGRID, IntAct30833792 details
CD74GRAMD1ABioGRID, IntAct30833792 details
CD74TBRG4BioGRID, IntAct30833792 details
CD74USP9XIntAct30833792 details
CD74ASCC1BioGRID, IntAct30833792 details
CD74ASCC3BioGRID, IntAct30833792 details
CD74DDX60BioGRID, IntAct30833792 details
CD74UBR4BioGRID, IntAct30833792 details
CD74PRRC2BBioGRID, IntAct30833792 details
CD74PPP6R3BioGRID, IntAct30833792 details
CD74PDCD4BioGRID, IntAct30833792 details
CD74UBE3CBioGRID, IntAct30833792 details
CD74RCN1BioGRID, IntAct30833792 details
CD74NCAPD2BioGRID, IntAct30833792 details
CD74PSMD6BioGRID, IntAct30833792 details
CD74GANABBioGRID, IntAct30833792 details
CD74FKBP8BioGRID, IntAct30833792 details
CD74EIF3ABioGRID, IntAct30833792 details
CD74IQGAP2BioGRID, IntAct30833792 details
CD74PDAP1BioGRID, IntAct30833792 details
CD74EIF3IBioGRID, IntAct30833792 details
CD74EIF2B5BioGRID, IntAct30833792 details
CD74CHAF1BBioGRID, IntAct30833792 details
CD74GTF3C1BioGRID, IntAct30833792 details
CD74EIF4G1BioGRID, IntAct30833792 details
CD74GTF2IBioGRID, IntAct30833792 details
CD74EIF4G2BioGRID, IntAct30833792 details
CD74YWHAZBioGRID, IntAct30833792 details
CD74SNRPEBioGRID, IntAct30833792 details
CD74YWHAEBioGRID, IntAct30833792 details
CD74EIF4A1BioGRID, IntAct30833792 details
CD74GEMIN4BioGRID, IntAct30833792 details
CD74EIF3BBioGRID, IntAct30833792 details
CD74HADHBBioGRID, IntAct30833792 details
CD74COPABioGRID, IntAct30833792 details
CD74COPB1BioGRID, IntAct30833792 details
CD74DGKEBioGRID, IntAct30833792 details
CD74SRP9BioGRID, IntAct30833792 details
CD74PRRC2ABioGRID, IntAct30833792 details
CD74ARCN1BioGRID, IntAct30833792 details
CD74MAP1BBioGRID, IntAct30833792 details
CD74NCAPD3BioGRID, IntAct30833792 details
CD74MTORBioGRID, IntAct30833792 details
CD74EIF2S3BioGRID, IntAct30833792 details
CD74PSMC2BioGRID, IntAct30833792 details
CD74COPB2BioGRID, IntAct30833792 details
CD74YWHABBioGRID, IntAct30833792 details
CD74TPP2BioGRID, IntAct30833792 details
CD74CANXBioGRID, IntAct30833792 details
CD74YWHAQBioGRID, IntAct30833792 details
CD74POLR2EBioGRID, IntAct30833792 details
CD74PCNABioGRID, IntAct30833792 details
CD74ASNSBioGRID, IntAct30833792 details
CD74EIF2S1BioGRID, IntAct30833792 details
CD74SGPL1BioGRID, IntAct30833792 details
CD74UBR5BioGRID, IntAct30833792 details
CD74IPO13BioGRID, IntAct30833792 details
CD74LTN1BioGRID, IntAct30833792 details
CD74EIF3JBioGRID, IntAct30833792 details
CD74EIF1BIntAct30833792 details
CD74AKAP8BioGRID, IntAct30833792 details
CD74PSMD3BioGRID, IntAct30833792 details
CD74EIF3HBioGRID, IntAct30833792 details
CD74EIF3DBioGRID, IntAct30833792 details
CD74PGRMC2BioGRID, IntAct30833792 details
CD74ANKRD28BioGRID, IntAct30833792 details
CD74POLR3ABioGRID, IntAct30833792 details
CD74AP3D1BioGRID, IntAct30833792 details
CD74EIF1AYIntAct30833792 details
CD74COPEBioGRID, IntAct30833792 details
CD74PPP6CIntAct30833792 details
CD74EIF3FBioGRID, IntAct30833792 details
CD74PGRMC1BioGRID, IntAct30833792 details
CD74VWA8BioGRID, IntAct30833792 details
CD74EIF1BioGRID30833792 details
CD74EIF3GBioGRID30833792 details
CD74EIF3MBioGRID30833792 details
CD74HMOX2BioGRID30833792 details
CD74KRT1BioGRID30833792 details
CD74NCAPHBioGRID30833792 details
CD74OSBPL8BioGRID30833792 details
CD74PHBBioGRID30833792 details
CD74POLR3BBioGRID30833792 details
CD74TUBA1ABioGRID30833792 details
CD74VDAC1BioGRID30833792 details
CD74IFITM3BioGRID30833792 details
CD74CUL7BioGRID31343991 details