Entity Details

Primary name HASP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TF76
EntryNameHASP_HUMAN
FullNameSerine/threonine-protein kinase haspin
TaxID9606
Evidenceevidence at protein level
Length798
SequenceStatuscomplete
DateCreated2004-03-01
DateModified2021-06-02

Ontological Relatives

GenesHASPIN

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0006468 protein phosphorylation
GO:0007064 mitotic sister chromatid cohesion
GO:0035556 intracellular signal transduction
GO:0071459 protein localization to chromosome, centromeric region
GO:0072354 histone kinase activity (H3-T3 specific)
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000751 histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR024604 Serine/threonine-protein kinase haspin, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04604 5-iodotubercidinDrugbanksmall molecule
DB07698 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amineDrugbanksmall molecule
DB07995 H-89Drugbanksmall molecule
DB08004 (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-olDrugbanksmall molecule