Entity Details

Primary name PPGB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10619
EntryNamePPGB_HUMAN
FullNameLysosomal protective protein
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCTSA

GO terms

Show/Hide Table
GOName
GO:0004180 carboxypeptidase activity
GO:0004185 serine-type carboxypeptidase activity
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0006508 proteolysis
GO:0006687 glycosphingolipid metabolic process
GO:0006886 intracellular protein transport
GO:0008047 enzyme activator activity
GO:0016020 membrane
GO:0031647 regulation of protein stability
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0070062 extracellular exosome
GO:1904714 regulation of chaperone-mediated autophagy
GO:1904715 negative regulation of chaperone-mediated autophagy

Subcellular Location

Show/Hide Table
Subcellular Location
Lysosome

Domains

Show/Hide Table
DomainNameCategoryType
IPR001563 Peptidase S10, serine carboxypeptidaseFamilyFamily
IPR018202 Serine carboxypeptidase, serine active siteSiteActive site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR033124 Serine carboxypeptidases, histidine active siteSiteActive site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB08934 SofosbuvirDrugbanksmall molecule
DB09299 Tenofovir alafenamideDrugbanksmall molecule
DB14761 RemdesivirDrugbanksmall molecule

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
PPGB_HUMANLT4R2_HUMANBioGRID, MINT28298427 details
PPGB_HUMANLMNA_HUMANBioGRID24623722 details
PPGB_HUMANVMAT1_HUMANBioGRID32296183 details
PPGB_HUMANFKBP7_HUMANBioGRID32296183 details
PPGB_HUMANSAR1A_HUMANBioGRID32296183 details
PPGB_HUMANAQP6_HUMANBioGRID32296183 details
PPGB_HUMANCOQ9_HUMANBioGRID32296183 details
PPGB_HUMANCD79A_HUMANBioGRID32296183 details
PPGB_HUMAN3HIDH_HUMANBioGRID32296183 details
PPGB_HUMANSTX2_HUMANBioGRID32296183 details
PPGB_HUMANCSPG5_HUMANBioGRID32296183 details
PPGB_HUMANGORAB_HUMANBioGRID32296183 details
PPGB_HUMANF209A_HUMANBioGRID32296183 details
PPGB_HUMANERGI3_HUMANBioGRID32296183 details
PPGB_HUMANNACHO_HUMANBioGRID32296183 details
PPGB_HUMANRN122_HUMANBioGRID32296183 details
PPGB_HUMANMYG1_HUMANBioGRID32296183 details
PPGB_HUMANMGST3_HUMANBioGRID32296183 details
PPGB_HUMANRHBL4_HUMANBioGRID32296183 details
PPGB_HUMANMF14B_HUMANBioGRID32296183 details
PPGB_HUMANTM237_HUMANBioGRID32296183 details
PPGB_HUMANCR3L1_HUMANBioGRID32296183 details
PPGB_HUMANZNT2_HUMANBioGRID32296183 details
PPGB_HUMANBSND_HUMANBioGRID32296183 details
PPGB_HUMANSMS2_HUMANBioGRID32296183 details
PPGB_HUMANSSMM1_HUMANBioGRID32296183 details
PPGB_HUMANCPLX4_HUMANBioGRID32296183 details
PPGB_HUMANAQP2_HUMANBioGRID32296183 details
PPGB_HUMANPSCA_HUMANBioGRID32296183 details
PPGB_HUMANREEP4_HUMANBioGRID32296183 details
PPGB_HUMANAR13B_HUMANBioGRID32296183 details
PPGB_HUMANTM154_HUMANBioGRID32296183 details
PPGB_HUMANFNDC9_HUMANBioGRID32296183 details
PPGB_HUMANTHAP4_HUMANBioGRID32296183 details
PPGB_HUMANTM139_HUMANBioGRID32296183 details
PPGB_HUMANTMM31_HUMANBioGRID32296183 details
PPGB_HUMANMUC1_HUMANBioGRID32296183 details
PPGB_HUMANAHNK2_HUMANBioGRID32296183 details
PPGB_HUMANLEUK_HUMANBioGRID32296183 details
PPGB_HUMANASPH_HUMANBioGRID32296183 details
PPGB_HUMANTMX2_HUMANBioGRID32296183 details
PPGB_HUMANSIG12_HUMANBioGRID32296183 details
PPGB_HUMANVIME_HUMANBioGRID, IntAct27173435 unassigned1312 details
PPGB_HUMANYPEL5_HUMANBioGRID, IntAct27173435 unassigned1312 details
PPGB_HUMANBGAL_HUMANBioGRID, HPRD, IntAct27173435 9501080 unassigned1312 details
PPGB_HUMANNEUR1_HUMANBioGRID, HPRD3102233 3922758 9501080 details
PPGB_HUMANABCE1_HUMANBioGRID25659154 details
PPGB_HUMANLAMP2_HUMANHPRD12505983 details
PPGB_HUMANPPGB_HUMANHPRD3136930 8591035 details