Entity Details

Primary name SPD2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA1X283
EntryNameSPD2B_HUMAN
FullNameSH3 and PX domain-containing protein 2B
TaxID9606
Evidenceevidence at protein level
Length911
SequenceStatuscomplete
DateCreated2007-12-04
DateModified2021-06-02

Ontological Relatives

GenesSH3PXD2B

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001654 eye development
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0006801 superoxide metabolic process
GO:0007507 heart development
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0022617 extracellular matrix disassembly
GO:0030054 cell junction
GO:0030154 cell differentiation
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0042169 SH2 domain binding
GO:0042995 cell projection
GO:0060090 molecular adaptor activity
GO:0060348 bone development
GO:0060612 adipose tissue development
GO:0071800 podosome assembly
GO:0072657 protein localization to membrane
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001683 Phox homologyDomainDomain
IPR030512 SH3 and PX domain-containing protein 2BFamilyFamily
IPR035477 SH3PXD2B, SH3 domain 1DomainDomain
IPR035478 SH3PXD2B, SH3 domain 2DomainDomain
IPR035479 SH3PXD2B, SH3 domain 3DomainDomain
IPR035480 SH3PXD2B, SH3 domain 4DomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036871 PX domain superfamilyFamilyHomologous superfamily
IPR037961 SH3PXD2, PX domainDomainDomain

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
SPD2B_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
SPD2B_HUMANSPD2B_HUMANMINT18959745 details
SPD2B_HUMANSH3K1_HUMANBioGRID19531213 details