Entity Details

Primary name TLE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04725
EntryNameTLE2_HUMAN
FullNameTransducin-like enhancer protein 2
TaxID9606
Evidenceevidence at protein level
Length743
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesTLE2

GO terms

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GOName
GO:0003714 transcription corepressor activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0009887 animal organ morphogenesis
GO:0016055 Wnt signaling pathway
GO:0016604 nuclear body
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1904837 beta-catenin-TCF complex assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR005617 Groucho/TLE, N-terminal Q-rich domainDomainDomain
IPR009146 Groucho/transducin-like enhancerFamilyFamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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