Entity Details

Primary name MEGF8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7Z7M0
EntryNameMEGF8_HUMAN
FullNameMultiple epidermal growth factor-like domains protein 8
TaxID9606
Evidenceevidence at protein level
Length2845
SequenceStatuscomplete
DateCreated2004-04-13
DateModified2021-06-02

Ontological Relatives

GenesMEGF8

GO terms

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GOName
GO:0003143 embryonic heart tube morphogenesis
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0009887 animal organ morphogenesis
GO:0009888 tissue development
GO:0010468 regulation of gene expression
GO:0016021 integral component of membrane
GO:0030326 embryonic limb morphogenesis
GO:0030509 BMP signaling pathway
GO:0035108 limb morphogenesis
GO:0042074 cell migration involved in gastrulation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048704 embryonic skeletal system morphogenesis
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0055113 epiboly involved in gastrulation with mouth forming second
GO:0060971 embryonic heart tube left/right pattern formation
GO:0060972 left/right pattern formation
GO:0060976 coronary vasculature development
GO:0061371 determination of heart left/right asymmetry
GO:0070062 extracellular exosome
GO:0071907 determination of digestive tract left/right asymmetry
GO:0097094 craniofacial suture morphogenesis
GO:0097155 fasciculation of sensory neuron axon

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000859 CUB domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002049 Laminin EGF domainDomainDomain
IPR002165 Plexin repeatRepeatRepeat
IPR015915 Kelch-type beta propellerFamilyHomologous superfamily
IPR016201 PSI domainDomainDomain
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR024731 EGF domainDomainDomain
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
MEGF8_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
MEGF8_HUMANGFI1B_HUMANBioGRID, HPRD, IntAct16713569 details
MEGF8_HUMANATX7_HUMANBioGRID, IntAct21078624 details
MEGF8_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
MEGF8_HUMANHXA1_HUMANMINT21653829 details