Entity Details

Primary name TMPS6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IU80
EntryNameTMPS6_HUMAN
FullNameTransmembrane protease serine 6
TaxID9606
Evidenceevidence at protein level
Length811
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesTMPRSS6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0004252 serine-type endopeptidase activity
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006879 cellular iron ion homeostasis
GO:0016021 integral component of membrane
GO:0022617 extracellular matrix disassembly
GO:0030514 negative regulation of BMP signaling pathway
GO:0030574 collagen catabolic process
GO:0033619 membrane protein proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0055072 iron ion homeostasis
GO:0097264 self proteolysis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000082 SEA domainDomainDomain
IPR000859 CUB domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR017118 Peptidase S1A, matriptase-2FamilyFamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036364 SEA domain superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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