Entity Details

Primary name PSD12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00232
EntryNamePSD12_HUMAN
FullName26S proteasome non-ATPase regulatory subunit 12
TaxID9606
Evidenceevidence at protein level
Length456
SequenceStatuscomplete
DateCreated2002-05-15
DateModified2021-06-02

Ontological Relatives

GenesPSMD12

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008541 proteasome regulatory particle, lid subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016579 protein deubiquitination
GO:0022624 proteasome accessory complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031595 nuclear proteasome complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034774 secretory granule lumen
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043312 neutrophil degranulation
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000717 Proteasome component (PCI) domainDomainDomain
IPR035297 26S Proteasome non-ATPase regulatory subunit 12FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR040134 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4FamilyFamily
IPR040896 26S proteasome regulatory subunit RPN5, C-terminal domainDomainDomain

Diseases

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Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
PSD12_HUMANPSD13_HUMANBioGRID, HPRD, IntAct16501559 17353931 22863883 22939629 26344197 28292943 28514442 details
PSD12_HUMANPSD10_HUMANBioGRID, IntAct17353931 19490896 22939629 28292943 28514442 details
PSD12_HUMANPSMD7_HUMANBioGRID, IntAct19615732 22863883 22939629 26186194 26344197 28292943 28514442 details
PSD12_HUMANPRS10_HUMANBioGRID, DIP, I2D, IntAct20890303 22863883 22939629 26344197 28292943 28514442 29636472 details
PSD12_HUMANPRS6B_HUMANBioGRID, IntAct22863883 22939629 26344197 28292943 28514442 details
PSD12_HUMANPSD11_HUMANBioGRID, DIP, IntAct22863883 22939629 26344197 27342858 28292943 28514442 details
PSD12_HUMANPRS6A_HUMANBioGRID, IntAct22939629 26186194 26344197 28292943 28514442 details
PSD12_HUMANPRS8_HUMANBioGRID, IntAct22863883 22939629 26344197 28292943 28514442 details
PSD12_HUMANDNJC5_HUMANBioGRID, IntAct29997244 details
PSD12_HUMANUBC_HUMANBioGRID16196087 28190767 details
PSD12_HUMANPSD12_HUMANBioGRID20890303 28292943 details
PSD12_HUMANCALM1_HUMANBioGRID15840729 details
PSD12_HUMANCALM2_HUMANBioGRID15840729 details
PSD12_HUMANCALM3_HUMANBioGRID15840729 details
PSD12_HUMANCDC42_HUMANBioGRID31478661 details
PSD12_HUMANOGT1_HUMANBioGRID32994395 details
PSD12_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct14743216 17353931 details
PSD12_HUMANTRM7_HUMANIntAct17353931 details
PSD12_HUMANIKKE_HUMANIntAct17353931 details
PSD12_HUMANNDKB_HUMANIntAct17353931 details
PSD12_HUMANSOMA_HUMANIntAct17353931 details
PSD12_HUMANPSMD4_HUMANBioGRID, DIP, IntAct, MINT16990800 22939629 26344197 28514442 30479383 details
PSD12_HUMANPSDE_HUMANBioGRID, IntAct17323924 19615732 22863883 22939629 26344197 26496610 27428775 28514442 28821611 30745168 details
PSD12_HUMANINTU_HUMANBioGRID, IntAct27173435 unassigned1312 details
PSD12_HUMANPSMD3_HUMANBioGRID, IntAct18775730 22863883 22939629 26344197 28514442 details
PSD12_HUMANSEM1_HUMANBioGRID16239144 18775730 details
PSD12_HUMANSEML_HUMANBioGRID16239144 18775730 details
PSD12_HUMANRD23A_HUMANBioGRID19013454 details
PSD12_HUMANFKBP8_HUMANBioGRID17573772 details
PSD12_HUMANPSA2_HUMANBioGRID19193609 22939629 26344197 details
PSD12_HUMANRNF11_HUMANBioGRID23751493 details
PSD12_HUMANFUS_HUMANBioGRID25192599 details
PSD12_HUMANENPP1_HUMANBioGRID27226596 details
PSD12_HUMANHMGB2_HUMANBioGRID27226596 details
PSD12_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PSD12_HUMANERPG3_HUMANBioGRID26030138 details
PSD12_HUMANERCC6_HUMANBioGRID26030138 details