Entity Details

Primary name SPT5H_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00267
EntryNameSPT5H_HUMAN
FullNameTranscription elongation factor SPT5
TaxID9606
Evidenceevidence at protein level
Length1087
SequenceStatuscomplete
DateCreated2005-11-22
DateModified2021-06-02

Ontological Relatives

GenesSUPT5H

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0016239 positive regulation of macroautophagy
GO:0019899 enzyme binding
GO:0032044 DSIF complex
GO:0032785 negative regulation of DNA-templated transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0050434 positive regulation of viral transcription
GO:1900364 negative regulation of mRNA polyadenylation

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR005100 NGN domainDomainDomain
IPR005824 KOWDomainDomain
IPR006645 NusG, N-terminalDomainDomain
IPR008991 Translation protein SH3-like domain superfamilyFamilyHomologous superfamily
IPR014722 Ribosomal protein L2, domain 2FamilyHomologous superfamily
IPR017071 Transcription elongation factor Spt5, eukaryoteFamilyFamily
IPR022581 Spt5 transcription elongation factor, N-terminalDomainDomain
IPR024945 Spt5 C-terminal domainDomainDomain
IPR036735 NusG, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039385 NGN domain, eukaryoticDomainDomain
IPR039659 Transcription elongation factor SPT5FamilyFamily
IPR041973 Spt5, KOW domain repeat 1DomainDomain
IPR041975 Spt5, KOW domain repeat 2DomainDomain
IPR041976 Spt5, KOW domain repeat 3DomainDomain
IPR041977 Spt5, KOW domain repeat 4DomainDomain
IPR041978 Spt5, KOW domain repeat 5DomainDomain
IPR041980 Spt5, KOW domain repeat 6DomainDomain

Diseases

Show/Hide Table

Interactions

134 interactions

InteractorPartnerSourcesPublicationsLink
SPT5H_HUMANZ512B_HUMANBioGRID, MINT15231748 details
SPT5H_HUMANZFYV9_HUMANBioGRID, HPRD, MINT15231748 details
SPT5H_HUMANTF3C1_HUMANHPRD, IntAct16169070 details
SPT5H_HUMANRED_HUMANHPRD, IntAct16169070 details
SPT5H_HUMANPNO1_HUMANHPRD, IntAct16169070 details
SPT5H_HUMANPHYIP_HUMANHPRD, IntAct16169070 details
SPT5H_HUMANPPIA_HUMANHPRD, IntAct16169070 details
SPT5H_HUMAN2ABD_HUMANHPRD, IntAct16169070 details
SPT5H_HUMANDREB_HUMANHPRD, IntAct16169070 details
SPT5H_HUMANS30BP_HUMANHPRD, IntAct16169070 details
SPT5H_HUMANH2AX_HUMANBioGRID, HPRD, IntAct16169070 28242625 details
SPT5H_HUMANSPT4H_HUMANBioGRID, DIP, HPRD, IntAct, MINT10075709 10454543 12653964 12718890 17404243 19860741 22939629 24981860 25416956 25502805 26344197 26496610 26789250 27107012 29395067 30217970 31515488 details
SPT5H_HUMANRPB1_HUMANBioGRID, DIP, HPRD, IntAct10075709 10454543 11940650 18197258 21880767 22939629 24814348 25416956 26344197 26496610 29395067 9450929 details
SPT5H_HUMANSNX4_HUMANBioGRID, IntAct21988832 details
SPT5H_HUMANLMAN2_HUMANBioGRID, IntAct21988832 details
SPT5H_HUMANSIK1_HUMANBioGRID, IntAct21988832 details
SPT5H_HUMANPIN1_HUMANBioGRID, HPRD, IntAct11575923 21988832 32296183 details
SPT5H_HUMANCSK21_HUMANBioGRID, IntAct22113938 26344197 details
SPT5H_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
SPT5H_HUMANHD_HUMANIntAct17500595 details
SPT5H_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
SPT5H_HUMANGOGA2_HUMANBioGRID, IntAct27107012 34079125 details
SPT5H_HUMANCEP55_HUMANBioGRID, IntAct27107012 details
SPT5H_HUMANTLE5_HUMANBioGRID, IntAct27107012 details
SPT5H_HUMANMD1L1_HUMANBioGRID, IntAct27107012 details
SPT5H_HUMANCDK7_HUMANBioGRID, DIP10958691 16327805 details
SPT5H_HUMANCDK9_HUMANBioGRID, DIP, HPRD10958691 11145967 11575923 15201869 16327805 23064645 details
SPT5H_HUMANANM5_HUMANBioGRID, HPRD, MINT12718890 24981860 details
SPT5H_HUMANSSBP3_HUMANBioGRID, IntAct20211142 details
SPT5H_HUMANMAML3_HUMANBioGRID, IntAct20211142 details
SPT5H_HUMANPHS_HUMANBioGRID, IntAct20211142 details
SPT5H_HUMANTF2H1_HUMANIntAct20211142 details
SPT5H_HUMANZBTB3_HUMANIntAct20211142 details
SPT5H_HUMANNEMO_HUMANBioGRID, IntAct20211142 details
SPT5H_HUMANZN496_HUMANBioGRID, IntAct20211142 details
SPT5H_HUMANANM1_HUMANBioGRID, HPRD12718890 details
SPT5H_HUMANCCNT1_HUMANBioGRID10958691 15201869 details
SPT5H_HUMANCCNH_HUMANBioGRID10958691 details
SPT5H_HUMANMAT1_HUMANBioGRID16327805 details
SPT5H_HUMANCCNT2_HUMANBioGRID15201869 details
SPT5H_HUMANFHL3_HUMANBioGRID30217970 details
SPT5H_HUMANTEX11_HUMANBioGRID30217970 details
SPT5H_HUMANSUMO2_HUMANBioGRID32786267 details
SPT5H_HUMANTLS1_HUMANHPRD16169070 details
SPT5H_HUMANDCAF6_HUMANHPRD16169070 details
SPT5H_HUMANMED31_HUMANIntAct16169070 details
SPT5H_HUMANCE126_HUMANIntAct16169070 details
SPT5H_HUMANRL8_HUMANIntAct16169070 details
SPT5H_HUMANRPR1B_HUMANBioGRID, IntAct26496610 29395067 details
SPT5H_HUMANSPT6H_HUMANBioGRID, IntAct26344197 26496610 29395067 details
SPT5H_HUMANCDC73_HUMANBioGRID, IntAct26496610 29395067 details
SPT5H_HUMANPHF3_HUMANBioGRID, IntAct26496610 29395067 details
SPT5H_HUMANRPRD2_HUMANBioGRID, IntAct26496610 29395067 details
SPT5H_HUMANAIPL1_HUMANBioGRID, IntAct27173435 unassigned1312 details
SPT5H_HUMANCEP43_HUMANBioGRID, IntAct27173435 unassigned1312 details
SPT5H_HUMANMIO_HUMANBioGRID, IntAct27173435 unassigned1312 details
SPT5H_HUMANPDE5A_HUMANBioGRID, IntAct27173435 unassigned1312 details
SPT5H_HUMANTNIK_HUMANIntAct31413325 details
SPT5H_HUMANDISC1_HUMANIntAct31413325 details
SPT5H_HUMANPP4C_HUMANBioGRID, MINT24981860 27880917 29395067 details
SPT5H_HUMANHTSF1_HUMANBioGRID, HPRD10454543 details
SPT5H_HUMANSMC3_HUMANBioGRID21880767 details
SPT5H_HUMANNELFB_HUMANBioGRID11940650 details
SPT5H_HUMANNSMF_HUMANBioGRID10199401 details
SPT5H_HUMANBRCA1_HUMANBioGRID18197258 details
SPT5H_HUMANNXF1_HUMANBioGRID22658674 29395067 details
SPT5H_HUMANSIR6_HUMANBioGRID24169447 details
SPT5H_HUMANRPB2_HUMANBioGRID26344197 26496610 29395067 details
SPT5H_HUMANRTF1_HUMANBioGRID26344197 29395067 details
SPT5H_HUMANUBR5_HUMANBioGRID27647897 29395067 details
SPT5H_HUMANMCE1_HUMANBioGRID27432908 27880917 28675297 29395067 details
SPT5H_HUMANARI1A_HUMANBioGRID29395067 details
SPT5H_HUMANARI1B_HUMANBioGRID29395067 details
SPT5H_HUMANCHD7_HUMANBioGRID29395067 details
SPT5H_HUMANC19L2_HUMANBioGRID29395067 details
SPT5H_HUMANDOT1L_HUMANBioGRID29395067 details
SPT5H_HUMANEP400_HUMANBioGRID29395067 details
SPT5H_HUMANBICRA_HUMANBioGRID29395067 details
SPT5H_HUMANGSE1_HUMANBioGRID29395067 details
SPT5H_HUMANINT1_HUMANBioGRID29395067 details
SPT5H_HUMANINT4_HUMANBioGRID29395067 details
SPT5H_HUMANJHD2C_HUMANBioGRID29395067 details
SPT5H_HUMANLENG8_HUMANBioGRID29395067 details
SPT5H_HUMANNCOA5_HUMANBioGRID29395067 details
SPT5H_HUMANNCOR1_HUMANBioGRID29395067 details
SPT5H_HUMANNCOR2_HUMANBioGRID29395067 details
SPT5H_HUMANNFRKB_HUMANBioGRID29395067 details
SPT5H_HUMANNPAT_HUMANBioGRID29395067 details
SPT5H_HUMANPCF11_HUMANBioGRID29395067 details
SPT5H_HUMANPP4R2_HUMANBioGRID29395067 details
SPT5H_HUMANP4R3B_HUMANBioGRID29395067 details
SPT5H_HUMANRBM33_HUMANBioGRID29395067 details
SPT5H_HUMANBRE1A_HUMANBioGRID29395067 details
SPT5H_HUMANBRE1B_HUMANBioGRID29395067 details
SPT5H_HUMANSCAFB_HUMANBioGRID29395067 details
SPT5H_HUMANSCAF4_HUMANBioGRID29395067 details
SPT5H_HUMANMINT_HUMANBioGRID29395067 details
SPT5H_HUMANTCF20_HUMANBioGRID29395067 details
SPT5H_HUMANWAC_HUMANBioGRID29395067 details
SPT5H_HUMANWDR33_HUMANBioGRID29395067 details
SPT5H_HUMANZC3H4_HUMANBioGRID29395067 details
SPT5H_HUMANPDCD4_HUMANBioGRID29395067 details
SPT5H_HUMANCMTR1_HUMANBioGRID29395067 details
SPT5H_HUMANTASOR_HUMANBioGRID29395067 details
SPT5H_HUMANZEP1_HUMANBioGRID29395067 details
SPT5H_HUMANINT10_HUMANBioGRID29395067 details
SPT5H_HUMANKMT2A_HUMANBioGRID29395067 details
SPT5H_HUMANKMT2D_HUMANBioGRID29395067 details
SPT5H_HUMANNIPBL_HUMANBioGRID29395067 details
SPT5H_HUMANRAVR1_HUMANBioGRID29395067 details
SPT5H_HUMANRCOR3_HUMANBioGRID29395067 details
SPT5H_HUMANSETD5_HUMANBioGRID29395067 details
SPT5H_HUMANZEB2_HUMANBioGRID29395067 details
SPT5H_HUMANCIC_HUMANBioGRID29395067 details
SPT5H_HUMANCPSF6_HUMANBioGRID29395067 details
SPT5H_HUMANICE1_HUMANBioGRID29395067 details
SPT5H_HUMANKDM2B_HUMANBioGRID29395067 details
SPT5H_HUMANSFR19_HUMANBioGRID29395067 details
SPT5H_HUMANSC61B_HUMANBioGRID29395067 details
SPT5H_HUMANZMYM4_HUMANBioGRID29395067 details
SPT5H_HUMANZN106_HUMANBioGRID29395067 details
SPT5H_HUMANCDC5L_HUMANBioGRID29395067 details
SPT5H_HUMANAQR_HUMANBioGRID29395067 details
SPT5H_HUMANBC11A_HUMANBioGRID29395067 details
SPT5H_HUMANCLP1_HUMANBioGRID29395067 details
SPT5H_HUMANCRNL1_HUMANBioGRID29395067 details
SPT5H_HUMANPRP16_HUMANBioGRID29395067 details
SPT5H_HUMANGPS2_HUMANBioGRID29395067 details
SPT5H_HUMANHDAC3_HUMANBioGRID29395067 details
SPT5H_HUMANINT12_HUMANBioGRID29395067 details
SPT5H_HUMANRECQ5_HUMANBioGRID29395067 details
SPT5H_HUMANUBN2_HUMANBioGRID29395067 details
SPT5H_HUMANSPT5H_HUMANHPRD10199401 11112772 11940650 details
SPT5H_HUMANXRCC5_HUMANHPRD12391174 details