Entity Details

Primary name CAC1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00555
EntryNameCAC1A_HUMAN
FullNameVoltage-dependent P/Q-type calcium channel subunit alpha-1A
TaxID9606
Evidenceevidence at protein level
Length2506
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCACNA1A

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0005245 voltage-gated calcium channel activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0008219 cell death
GO:0008331 high voltage-gated calcium channel activity
GO:0016021 integral component of membrane
GO:0019905 syntaxin binding
GO:0034765 regulation of ion transmembrane transport
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0046872 metal ion binding
GO:0050796 regulation of insulin secretion
GO:0050804 modulation of chemical synaptic transmission
GO:0051899 membrane depolarization
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR002077 Voltage-dependent calcium channel, alpha-1 subunitFamilyFamily
IPR005448 Voltage-dependent calcium channel, P/Q-type, alpha-1 AFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR031649 Voltage-dependent L-type calcium channel, IQ-associated domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00653 Magnesium sulfateDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00825 LevomentholDrugbanksmall molecule
DB00836 LoperamideDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB06283 ZiconotideDrugbanksmall molecule
DB06446 DotarizineDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09231 BenidipineDrugbanksmall molecule
DB09232 CilnidipineDrugbanksmall molecule
DB09236 LacidipineDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

98 interactions

InteractorPartnerSourcesPublicationsLink
CAC1A_HUMANABI1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANABCA2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANGET3_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANRHG22_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANAP2M1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANAMGO2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANALDOA_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANACTN1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANCKAP5_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANCALM2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANC1QT1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANRIMB1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANCRIM1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANHHATL_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANGRN_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANFBLN1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANEIF3A_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANEHMT2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANFBLN4_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANFBLN3_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANDNJB5_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANCSK2B_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANKALRN_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANHECW1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANKHDR3_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANJAG2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANIP6K1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPGBM_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANZEP1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANP33MX_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANSRRM4_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANLRP1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANAGRL1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANL2GL1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANTELO2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANMEGF6_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANMATN2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANMATK_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANMANBL_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANLTBP4_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANMEGF8_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANTGO1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANMOAP1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANNDUB8_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANNELL2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANNELL1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANCRTP1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANNOTC1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANNOXA1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPCSK5_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPCSK6_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPMM1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPPIG_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPP12C_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANOLIG1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANRB12B_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANRIMB2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANRL31_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANRS17_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANSCP2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPTGDS_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANT22D1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANNELFD_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANRBP56_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANSUMF2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANSPY1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANSRSF1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANPUF60_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANWBP1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANVWF_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANVPS52_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANSYVC_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANQCR2_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANTBB2B_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANTSN7_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANNO40_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANZN233_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANYLPM1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANGG6L9_HUMANIntAct21078624 details
CAC1A_HUMANAGRIN_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANLAMB1_HUMANBioGRID, IntAct21078624 details
CAC1A_HUMANCABP1_HUMANBioGRID, HPRD11865310 14570872 details
CAC1A_HUMANCACB4_HUMANBioGRID, HPRD10212211 9442082 details
CAC1A_HUMANSYT1_HUMANBioGRID, HPRD9303303 details
CAC1A_HUMANBTG3_HUMANBioGRID21078624 details
CAC1A_HUMANCALM1_HUMANBioGRID21078624 details
CAC1A_HUMANCALM3_HUMANBioGRID21078624 details
CAC1A_HUMANDPYL1_HUMANBioGRID21078624 details
CAC1A_HUMANLTBP1_HUMANBioGRID21078624 details
CAC1A_HUMANLTBP3_HUMANBioGRID21078624 details
CAC1A_HUMANKDM5B_HUMANBioGRID19336002 details
CAC1A_HUMANGBB2_HUMANBioGRID9238069 details
CAC1A_HUMANKLHL1_HUMANBioGRID17289272 details
CAC1A_HUMANUB2L3_HUMANBioGRID25483588 details
CAC1A_HUMANMAP1B_HUMANBioGRID25483588 details
CAC1A_HUMANCACB1_HUMANHPRD1370480 details
CAC1A_HUMANPPM1A_HUMANHPRD15728831 details
CAC1A_HUMANGBB1_HUMANHPRD9009193 details