Entity Details

Primary name EZH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92800
EntryNameEZH1_HUMAN
FullNameHistone-lysine N-methyltransferase EZH1
TaxID9606
Evidenceevidence at protein level
Length747
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesEZH1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000781 chromosome, telomeric region
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005654 nucleoplasm
GO:0006338 chromatin remodeling
GO:0006348 chromatin silencing at telomere
GO:0009653 anatomical structure morphogenesis
GO:0018024 histone-lysine N-methyltransferase activity
GO:0021766 hippocampus development
GO:0031507 heterochromatin assembly
GO:0035098 ESC/E(Z) complex
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070734 histone H3-K27 methylation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001005 SANT/Myb domainDomainDomain
IPR001214 SET domainDomainDomain
IPR021654 Histone-lysine N-methyltransferase EZH1/EZH2FamilyFamily
IPR026489 CXC domainDomainDomain
IPR032926 Histone-lysine N-methyltransferase EZH1FamilyFamily
IPR033467 Tesmin/TSO1-like CXC domainDomainDomain
IPR041343 Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domainDomainDomain
IPR041355 Pre-SET CXC domainDomainDomain
IPR044438 EZH1, SET domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12887 TazemetostatDrugbanksmall molecule